Grid deformation strategies for CFD analysis of screw compressors

Customized grid generation of twin screw machines for CFD analysis is widely used by the refrigeration and air-conditioning industry today, but is currently not suitable for topologies such as those of single screw, variable pitch or tri screw rotors. This paper investigates a technique called key-frame re-meshing that supplies pre-generated unstructured grids to the CFD solver at different time steps. To evaluate its accuracy, the results of an isentropic compression-expansion process in a reciprocating piston cylinder arrangement have been compared. Three strategies of grid deformation; diffusion equation mesh smoothing, user defined nodal displacement and key-frame remeshing have been assessed. There are many limitations to key-frame re-meshing. It requires time consuming pre-processing, has limited applicability to complex meshes and leads to inaccuracies in conservation of calculated variables. It was concluded that customized tools for generation of CFD grids are required for complex screw machines.     

A switching system based on microcontroller for successive applying of MGT and CPT on MOSFETs

A new, low cost switching system based on PIC 18F4550 microcontroller (MCU), called APL-SM v1.0 system, which enables the successive measuring of both the electrical characteristics in midgap-subthreshold technique (MGT) and charge-pumping currents in charge-pumping technique (CPT) of metal–oxide–semiconductor field effect transistor (MOSFET), has been developed. The APL-SM v1.0 system, instead of expensive switching matrix which price is considerably higher, could be used for the switching from MGT to CPT and vice versa. Using the appropriate program, the system allows the monitoring of MOSFETs during long time periods, helping the performing of long lasting experiments. The good agreement in the electrical characteristics, as well as in the charge-pumping currents, obtained using ultra low current, high speed Keithley switching matrix (SM) and APL-SM system, was obtained.     

Direct potentiometric determination of diastase activity in honey

A novel method for the determination of diastase activity is reported. The method is based on a direct potentiometric measurement of triiodide ion that is released when a starch-triiodide complex is hydrolysed by honey diastase. The increase of free triiodide ion concentration in a sample is found to be directly proportional to the diastase activity of the sample. A response mechanism of the platinum redox electrode is proposed, allowing a calculation of the diastase activity factor (F). The sensor and analyte parameters, including F, were obtained by least squares fitting of potentiometric data using the optimisation function of the Solver add-in of Microsoft Excel. The values of F obtained by the new direct potentiometric method were compared with those obtained using the standard Phadebas method (DN values), and the two values were found to agree within experimental error. Finally, the diastase activity of nine varieties of honey was determined using the novel method developed here.     

Performance Analysis of System with Micro- and Macrodiversity Reception in Correlated Gamma Shadowed Rician Fading Channels

In this paper, the performance of wireless system employing microdiversity to mitigate the effects of short-term fading and macrodiversity to reduce long-term fading (shadowing) effects is studied. The system model assumes implementation of maximal-ratio combining (MRC) at the microlevel and selection combining (SC) at the macrolevel. The received signal envelope follows a Rician distribution and it also suffers gamma shadowing. Novel expressions for the probability density function (PDF), cumulative distribution function (CDF), and moment-generating function (MGF) of the output signal-to-noise ratio (SNR) are obtained. Several useful performance criteria, such as the moments of the output SNR and outage probability are analytically derived. Moreover, the average bit error probability (ABEP) for noncoherent binary differential phase-shift keying (BDPSK) is calculated using the MGF based approach while the ABEP for coherent binary phase-shift keying (BPSK) is studied by averaging the conditional bit error probability over the PDF. Numerical results are graphically presented to show the effects of various system parameters to the system performance, as well as the enhancement due to use of the combination of micro- and macrodiversity. Some of numerical results are complemented by equivalent computer simulated results which validate the accuracy of the proposed analysis. The agreement between the Rician-gamma and Rician-lognormal fading model is also established.     

The Role of Altered Nucleotide Excision Repair and UVB-Induced DNA Damage in Melanomagenesis

UVB radiation is the most mutagenic component of the UV spectrum that reaches the earth’s surface and causes the development of DNA damage in the form of cyclobutane pyrimidine dimers and 6-4 photoproducts. UV radiation usually results in cellular death, but if left unchecked, it can affect DNA integrity, cell and tissue homeostasis and cause mutations in oncogenes and tumour-suppressor genes. These mutations, if unrepaired, can lead to abnormal cell growth, increasing the risk of cancer development. Epidemiological data strongly associates UV exposure as a major factor in melanoma development, but the exact biological mechanisms involved in this process are yet to be fully elucidated. The nucleotide excision repair (NER) pathway is responsible for the repair of UV-induced lesions. Patients with the genetic disorder Xeroderma Pigmentosum have a mutation in one of eight NER genes associated with the XP complementation groups XP-A to XP-G and XP variant (XP-V). XP is characterized by diminished repair capacity, as well as a 1000-fold increase in the incidence of skin cancers, including melanoma. This has suggested a significant role for NER in melanoma development as a result of UVB exposure. This review discusses the current research surrounding UVB radiation and NER capacity and how further investigation of NER could elucidate the role of NER in avoiding UV-induced cellular death resulting in melanomagenesis.     

Second‐Order Statistics of System with Microdiversity and Macrodiversity Reception in Gamma‐Shadowed Rician Fading Channels

In this letter, a wireless communication system with microdiversity and macrodiversity reception in gamma‐shadowed Rician fading channels is considered. Exact and rapidly converging infinite‐series expressions for the average level crossing rate and average fade duration at the output of the system are provided. Numerical results are presented graphically to illustrate the proposed mathematical analysis and to examine the effects of the system's parameters on the quantities considered.     

Structural destabilisation of MgH2 obtained by heavy ion irradiation

MgH₂ powder samples have been irradiated with 120 keV Ar⁺⁸ ions with different ion fluencies ranging from 10¹² to 10¹⁶ ions/cm². Irradiation effects are estimated by SRIM calculations, and investigated experimentally using Raman spectroscopy and X-ray diffraction (XRD) analysis. The observed changes of structure and vibrational spectra are elaborated, their consequences on hydrogen bonding in MgH₂ discussed, and influence on H-desorption properties investigated by Temperature Programmed Desorption (TPD) and Differential Scanning Calorimetry (DSC) techniques. It has been established that near-surface defects have a predominant influence on decreasing the H-desorption temperature. Variations of Raman, TPD and DSC spectra with irradiation conditions suggest that there are several mechanisms of dehydriding, and that they depend on defect concentration, interaction and ordering.     

The Hydrophilic Loop of Arabidopsis PIN1 Auxin Efflux Carrier Harbors Hallmarks of an Intrinsically Disordered Protein

Much of plant development depends on cell-to-cell redistribution of the plant hormone auxin, which is facilitated by the plasma membrane (PM) localized PIN FORMED (PIN) proteins. Auxin export activity, developmental roles, subcellular trafficking, and polarity of PINs have been well studied, but their structure remains elusive besides a rough outline that they contain two groups of 5 alpha-helices connected by a large hydrophilic loop (HL). Here, we focus on the PIN1 HL as we could produce it in sufficient quantities for biochemical investigations to provide insights into its secondary structure. Circular dichroism (CD) studies revealed its nature as an intrinsically disordered protein (IDP), manifested by the increase of structure content upon thermal melting. Consistent with IDPs serving as interaction platforms, PIN1 loops homodimerize. PIN1 HL cytoplasmic overexpression in Arabidopsis disrupts early endocytic trafficking of PIN1 and PIN2 and causes defects in the cotyledon vasculature formation. In summary, we demonstrate that PIN1 HL has an intrinsically disordered nature, which must be considered to gain further structural insights. Some secondary structures may form transiently during pairing with known and yet-to-be-discovered interactors.     

基于众包的嵌套流形匹配室内定位方法

随着普适应用的兴起,室内定位变得越来越重要。传统的基于指纹的定位方法需要现场勘测,所需时间及工作量巨大,且需实时更新,以适应室内变化,这大大限制了其应用范围。采用众包形式进行室内信息采集,并记录其在室内的大量路径信息,利用嵌套在路径中的低维流形一致性进行地理位置匹配,以建立位置指纹库。通过高斯粒子滤波器对传感器数据进行去噪,进而解决步长差异问题。定位时,根据用户位置的连续性和路径信息筛选出合理的近邻点,继而实现精确定位。在84m²的会议室进行实验,在不需要现场勘测的情况下,所提方法可达到与传统方法可比的定位精度。该方法可以实时适应环境变化,在2周甚至1个月之后,其定位准确性优于传统定位方法。