In vitro biotransformation of (R)- and (S)-thalidomide: application of circular dichroism spectroscopy to the stereochemical characterization of the hydroxylated metabolites

Circular dichroism (CD) spectroscopy was successfully used for the stereochemical characterization of the hydroxylated metabolites formed during the in vitro biotransformation of (R)- and (S)-thalidomide. Incubation extracts of the individual enantiomers were analyzed by HPLC on an achiral stationary phase combined with CD detection. The CD data of the almost enantiopure eluates of the metabolites were compared with the CD spectra quantum chemically calculated for the respective structures. The results allowed us a reliable determination of the absolute stereostructure for all of the metabolites. The chiral center of thalidomide is unaffected by the stereoselective biotransformation process. (3'R,5'R)-trans-5'-hydroxythalidomide is the main metabolite of (R)-thalidomide, which epimerizes spontaneously to give the more stable (3'S,5'R)-cis isomer. On the contrary, (S)-thalidomide is preferentially metabolized by hydroxylation in the phthalimide moiety, resulting in the formation of (S)-5-hydroxythalidomide.     

Abusive testing of large Li/SOCl2 cells

Results are reported of various abuse tests conducted with lithium-thionyl chloride primary batteries of 2 000 A h and 10 000 A h capacity. The mechanical abuse tests, such as shock and vibration, showed that the large prismatic cells can now be built to satisfy typical military requirements. The thermal abuse tests showed that the cells can withstand a considerable overheating or a thermal shock treatment, as long as provisions were made for the thermal expansion of the electrolyte. The electrochemical abuse tests showed that the cells could be overdischarged (driven in reverse beyond discharge) to an equivalent of up to 50% of the discharge capacity with no adverse effects. The short circuit test, as a combination of the electrochemical and thermal abuse, was performed with no rupture, explosion or any other adverse effects on the surroundings.     

A multimodal hand-based verification system with an aliveness-detection module

This paper presents a multimodal biometrie verification system based on the following hand features: palmprint, four digitprints and four fingerprints. The features are obtained using the Karhunen-Loève transform based approach, and information fusion at the matching-score level was applied. We experimented with different resolutions of the regions of interest, different numbers of features and several normalization and fusion techniques at the matching-score level. To increase the reliability of the system to spoof attacks we included an aliveness-detection module based on thermal images of the hand dor sa. The verification performance when using a system configuration with optimum parameters, i.e., resolution, number of features, normalization and fusion technique, showed an equal error rate (EER) of 0.0020%, which makes the system appropriate for the implementation of high-security biometric systems.     

Fractal substructure of a nanopowder generated by repeated fragmentation and sedimentation: the rôle of the dust

Packings of cohesive nanoparticles, that is nanopowders, may be obtained as the result of repeated fragmentation–reagglomeration cycles (Schwager et al. in Phys Rev Lett 100:218002, 2008) such that the resulting sediment reveals a fractal structure. The size distribution of the fragments after a fragmentation step is a superposition of a narrow distribution of large particles (chunks) whose size is determined by the cutting length and a power-law distribution for small particles, representing scale invariant dust. It was shown that the exponent of the power-law, \(\tau \), is in non-trivial relation to the fractal dimension, \(d_f\), via \(d_f(2-\tau )=1\). This poses the question for the structure of the sediment created by repeated fragmentation–reagglomeration cycles when the dust particles are excluded from the reagglomeration step. We found that even in this case, repeated fragmentation–reagglomeration cycles yield a sediment of fractal structure with slightly reduced fractal dimension while the dust exponent, \(\tau \), remains unchanged.     

INFERENCE PROCEDURES FOR FUZZY KNOWLEDGE REPRESENTATION SCHEME

This article presents a formal model of the knowledge representation scheme based on the fuzzy Petri net (FPN) theory. The model is represented as a 13-tuple consisting of the components of the FPN, two functions that give semantic meanings to the scheme and a set of contradictions. For the scheme, called the knowledge representation scheme based on the fuzzy Petri nets theory (KRFPN) the fuzzy inheritance and fuzzy recognition-inference procedures based on the dynamical properties of the FPN, are described in detail. The upper-time complexity of both the proposed inference algorithms is O(nm), where n is the number of places (concepts) and m is the number of transitions (relations) in the scheme. Illustrative examples of the fuzzy inheritance and the fuzzy recognition algorithms for the knowledge base, designed by the KRFPN, are given.     

Process Scheduling Procedure for a Class of Real-Time Comuter Systems

The paper presents the results of the performance evaluation study for a class of real-time computer systems intended for industrial process applications. The developed measures will improve the response time of the system, under the condition of high data arrival rates, where task context switching time and associated overhead are highly exhibited. A discretionary dynamic scheduling and selection discipline is synthesized, producing the minimum global expected waiting time in the system, under the given conditions.     

Estimation of the number of trays for natural gas triethylene glycol dehydration column

The paper deals with the tray-to-tray method for determining the required number of trays in columns with intensive entrainment of liquid when the operating line of the “dry working regime” is not straight and with a small concentration of diffusing component in gas. Presented calculations show that the number of transfer units for gas and liquid should be calculated using the AIChE method accompanied with longitudinal mixing according to Gilbert properly transformed for case of diffusion through stagnant film. The suggested method can be applied for TEG dehydration absorbers-columns for dehydration of natural gas using triethylene glycol with system factor SF = 0.5.     

Carcinogenic properties of silicon carbide whiskers

In experiments with intrapleural injections of silicon carbide whiskers (20 mg X 3, with one month interval) to random-inbred rats their carcinogenic activity close to that of chrysotile B UICC has been established. The pleural mesotheliomas were induced in 47.7 and 34.1% of rats, respectively.