The Marine Polyketide Myriaporone 3/4 Stalls Translation by Targeting the Elongation Phase

Myriaporone 3/4, a cytotoxic polyketide, has been reported as an inhibitor of eukaryotic protein synthesis. However, the mechanism by which it inhibits translation was unknown. Here we show that myriaporone 3/4 stalls protein synthesis in the elongation phase by inducing phosphorylation of eukaryotic elongation factor 2. The phosphorylation results from direct binding of myriaporone 3/4 to eukaryotic elongation factor 2 kinase. Our study also shows that myriaporone 3/4 in the nanomolar range inhibits in vitro tube formation by endothelial cells without being cytotoxic. In general, myriaporone 3/4 was at least 300 times less toxic to primary cells than to tumor cells.     

Microbial desulfurization of three different coals from Indonesia, China and Korea in varying growth medium

Shake flask studies on microbial desulfurization of three different coal samples (Indonesian lignite, Chinese lignite and Korean anthracite) were performed to optimize the best suitable growth medium. Among the three different growth mediums (basal salt medium, basal salt medium supplemented with 9 g/L Fe and basal salt medium supplemented with 2.5% S⁰) tested, the basal salt medium was found to be the best, considering process dynamics and economical factors. The extent of pyrite oxidation was highest with 95% in the experiments with Korean anthracite in basal salt medium supplemented with 9 g/L Fe, while the lowest pyrite oxidation of 70–71% was observed in the experiments with Indonesian and Chinese Lignite’s in only basal salt medium. The microbial sulfur removal in the experiments with basal salt medium supplemented with 9 g/L Fe for all the three coal samples was between 94–97%, while the experiments on basal salt medium supplemented with 2.5% S⁰ for all the coal samples were relatively much lower ranging between 27–48%. However, the overall study resulted with promising directions for further scaling up of microbial desulphurization in a best growth medium devoid of iron and sulfur supplement.     

Separations of toxic metal ions using a novel polymeric composite: Synthesis,characterizations, kinetics,isotherm models and thermal degradation studies

A composite material was prepared using terpolymer and activated charcoal. The material was spectrally characterized, and the morphology and thermal stability were investigated by scanning electron microscopy (SEM) and thermogravimetric analysis (TGA), respectively. From the metal ion sorption results, it was found that the composite material had significantly removed the selected metal ions from the aqueous solution. This may be due to the highly porous nature and the larger specific surface area of the composite. The results were well fitted with the Langmuir isotherm and follow the first-order kinetics. The thermal degradation kinetics and thermodynamic parameters were also calculated from thermogravimetric data and reported.     

Resource key distribution and allocation based on sensor vehicle nodes for energy harvesting in vehicular ad hoc networks for transport application

The Journal of Supercomputing - With vehicular ad hoc networks (VANETs) increasingly becoming a term synonymous with inter-vehicle communication, a lot of research is being carried out in this line...     

Design of sign fractional optimization paradigms for parameter estimation of nonlinear Hammerstein systems

Neural Computing and Applications - Fractional calculus plays a fundamental role in understanding the physics of nonlinear systems due to its heritage of uncertainty, nonlocality and complexity. In...     

A NLP framework based on meaningful latent-topic detection and sentiment analysis via fuzzy lattice reasoning on youtube comments

Multimedia Tools and Applications - Social media platforms such as Twitter, Facebook, and YouTube have unique architecture, norms, and culture. These platforms are valuable sources of...     

Free standing copper incorporated carbon nanofibers based flexible anodes for high performance sodium ion batteries

Microsystem Technologies - In the era of sustainable and clean transportation, electric vehicles are the key to usher. Among carbonaceous materials, carbon nanofibers are inexpensive catalyst that...     

Risk of Fuel Spills and the Transient Models of Spill Area Forecasting

Journal of Failure Analysis and Prevention - Most accidents in chemical process industry, as well as a large number of fires in general, are triggered by accidental spilling of flammable liquids....     

Diversifying personalized mobile multimedia application recommendations through the Latent Dirichlet Allocation and clustering optimization

Multimedia Tools and Applications - The rapid development of mobile multimedia applications explosively increased the availability of the number of applications in the apps market. Among the crowd...