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A simple ternary complex model of drug-receptor interaction has been used to extend the procedure of pharmacological resultant analysis, enabling the quantitation of interactions between allosteric modulators and orthosteric antagonists. Equations derived in the theoretical treatment were used to analyse functional data for the interaction between the allosteric modulator gallamine and the orthosteric antagonist scopolamine, with oxotremorine as the agonist, at rat tracheal muscarinic acetylcholine receptors. Quantitative estimates of the affinity of gallamine for the allosteric site (pKz = 4.7) and the extent of negative, heterotropic co-operativity between gallamine and scopolamine (alpha' = 13.1) were obtained. Furthermore, an alternative direct, model-fitting approach, that does not rely on the determination of concentration ratios, was also developed, and yielded similar results. It is suggested that the approach presented in this paper is useful for quantifying interactions between orthosteric antagonists and allosteric modulators, particularly when the extent of co-operativity is low or the modulators possess multiple pharmacological properties, or both.  相似文献   
995.
Spatial soliton-induced guiding by cross-phase modulation   总被引:1,自引:0,他引:1  
The authors show that spatial solitons are able to induce the stable guiding of a weak probe beam in a homogeneous Kerr-type nonlinear media through cross-phase modulation (XPM). The modes of the induced waveguide are derived from the propagation equation of the probe. Experiments have been performed in Kerr liquid CS2, with beams of picosecond duration at infrared and visible wavelengths. Stable guiding of a green probe induced by an IR soliton beam has been demonstrated in several different experimental situations. Induced antiguiding and beam splitting are also reported for pump and probe of perpendicular polarizations. All results are in excellent agreement with numerical simulations of the propagation  相似文献   
996.
General methodological and mathematical aspects of using tomographic approach to reconstructing the inner structure of surface layers and films on the most abundant nonuniformity types characteristic of heterogeneous physico-chemical nanosystems are discussed. Spectral ellipsometric measurement of light reflected from a nonuniform surface nanolayer allows substantiating spectral-tomographic principle and reconstructing the inner structure of the layer by solving an integral equation of the 1st kind. Principles and mathematic fundamentals of ellipsometric spectral tomography are presented, which may be used in nondestructively monitoring the distribution of physico-chemical properties over the bulk of nonuniform metal–oxide surface structures.  相似文献   
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Mercury Penetration Technique and Grain Size Analysis of Concrete The paper describes the behaviour of hardened cement paste and concrete under high velocity water jet attack. Using mercury penetration technique and grain size analysis method, the failure performance is identified as a fracture mechanical one. The behaviour of the materials is influenced due to aggregate grains.  相似文献   
999.
Microbial deterioration of materials – case histories and countermeasures: Legal aspects of environmental protection Biofouling is a natural process. Usually, it does not cause too much harm if taken care of properly. If biofouling is fought by special means, problems may arise. The waste water does not meet the due standards. Sometimes the recipe of the treatment agent is not known. If the treatment causes more problems than it can solve help is needed quickly. Yet, it is advisable to keep one's mind clear. Wrong help can become very expensive. In addition, legal punishment will follow, if environmental legislation is hurt. Damages of the environment will be payed by an insurance company only, if the risk is covered by the insurance contract in advance. The best way to be sure is to have a good lawyer, a good expert in environmental techniques and environmental legislation, a good insurance, and to anticipate possible risks.  相似文献   
1000.
InGaAs/GaAs(100) multiple-quantum-well-based inverted cavity asymmetric Fabry-Perot modulators are vertically integrated with GaAs/AlGaAs heterojunction phototransistors to yield all-optical photonic switches. The photonic switches using `normally on' modulator pixels exhibit an output on-off ratio of 12:1 with internal optical gain of 4 dB. The photonic switches using `normally off' modulator pixels yield similar contrast and gain, but exhibit intrinsic bistable behavior. The inverted cavity modulators employed permit utilizing the transparency of the GaAs substrate at the operating wavelength and offer advantages for fabricating large arrays for optical signal processing  相似文献   
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