Compressibility effects on outflows in a two-fluid system. 1. Line source in cylindrical geometry

A two-dimensional line source outflow is considered, in which the evolution of a sharp interface separating an incompressible fluid from a bounding weakly compressible gas is analysed. Linear theory is applied, assuming that anisotropies in the source outflow are small, to develop an approximate solution for the interfacial evolution. The simplest solutions to the governing linearised equations require the presence of a high-order velocity singularity at the location of the line source. A spectral method is also developed to capture the nonlinear behaviour of the flow; after some finite time, curvature singularities are found to develop on the interface. Comparisons are made between the stability of the interface and its analogue which separates two incompressible fluids. It is found that when the bounding fluid is weakly compressible rather than incompressible, the stability of the interface is significantly increased.     

Segmentation of multiple sclerosis lesions in brain MRI: A review of automated approaches

Automatic segmentation of multiple sclerosis (MS) lesions in brain MRI has been widely investigated in recent years with the goal of helping MS diagnosis and patient follow-up. However, the performance of most of the algorithms still falls far below expert expectations. In this paper, we review the main approaches to automated MS lesion segmentation. The main features of the segmentation algorithms are analysed and the most recent important techniques are classified into different strategies according to their main principle, pointing out their strengths and weaknesses and suggesting new research directions. A qualitative and quantitative comparison of the results of the approaches analysed is also presented. Finally, possible future approaches to MS lesion segmentation are discussed.     

Crack tip identification with long FBG sensors in mixed-mode delamination

The uncertainty of the crack tip position inside composite coupons during a delamination test under variable fracture mode conditions reduces the accuracy of the experimental results. In this work a method is presented where the crack tip position is located using long embedded Fibre Bragg Grating (FBG) sensors together with the Optical Low Coherence Reflectometry (OLCR) technique. With this technique the local Bragg wavelength is measured which then enables to calculate the axial strain profile within the grating. Carbon/epoxy samples are tested under different mode ratios through the standard Mixed-Mode Bending (MMB) test. Embedded long FBG sensors are used to measure the axial strain profile along the whole grating at different stages of the test. The crack tip can be precisely identified with the long embedded FBGs and then checked by means of a visual inspection after complete delamination of the sample. The data indicate that the long FBG sensor detects the crack tip inside the sample at least as precisely as the traditionally performed visual inspections carried out during the test by means of the lateral markings. Numerical simulations using cohesive elements are in good agreement with the experimental data.     

The Routineness of Routines: Measuring Rhythms of Media Interaction

The routines of information work are commonplace yet difficult to characterize. Although cognitive models have successfully characterized routine tasks within which there is little variation, a large body of ethnomethodological research has identified the inherent nonroutineness of routines in information work. We argue that work does not fall into discrete classes of routine versus nonroutine; rather, task performance lies on a continuum of routineness, and routineness metrics are important to the understanding of workplace multitasking.

In a study of 10 information workers shadowed for 3 whole working days each, we utilize the construct of working sphere to model projects/tasks as a network of humans and artifacts. Employing a statistical technique called T-pattern analysis, we derive measures of routineness from these real-world data. In terms of routineness, we show that information workers experience archetypes of working spheres. The results indicate that T-patterns of interactions with information and computational media are important indicators of facets of routineness and that these measures are correlated with workers' affective states. Our results are some of the first to demonstrate how regular temporal patterns of media interaction in tasks are related to stress. These results suggest that designs of systems to facilitate so-called routine work should consider the degrees to which a person's working spheres fall along varying facets of routineness.     

Modeling the effect of a superabsorbent polymer material as desiccant in maize drying using CFD

Maize is an important foodstuff in many countries, and one of most susceptible crops to mold and aflatoxin contamination, which results in considerable postharvest losses and is a burden to consumers’ health, especially in developing countries. The timely drying of harvested maize is essential to halt mold development, ensuring safe storage. The effect of the incorporation of a superabsorbent polymer (SAP) as desiccant in a maize dryer was studied using computational fluid dynamics simulations which accounted for heat and mass transfer between maize, SAP and air. The adsorption capacity and adsorption rate of a commercial SAP material were experimentally determined at different temperature and relative humidity levels, which served as basis for the adsorption model required in the simulations. A maize bulk with SAP packages distributed in it was modeled. Results showed that the SAP material increases the drying rate substantially, particularly in the upper bulk zone where the air reaching it is dehumidified the most. The maize closer to the upper bulk surface starts drying from the beginning of the process instead of lagging for hours or days before the drying front reaches it. An inconvenience of the SAP material is the tendency of granules to swell and stick together as moisture reaches a threshold, which may reduce its performance. Thus, provided this issue is resolved or minimized, SAP materials could successfully assist the rapid drying of maize and other crops. They may also be used during storage to avoid rewetting of the crops during periods of high relative humidity.     

A Third Order Hierarchical Basis WENO Interpolation for Sparse Grids with Application to Conservation Laws with Uncertain Data

In this paper, we introduce a third order hierarchical basis WENO interpolation, which possesses similar accuracy and stability properties as usual WENO interpolations. The main motivation for the hierarchical approach is the direct applicability on sparse grids. This is for instance of large practical interest in the numerical solution of conservation laws with uncertain data, where discontinuities in the physical domain often carry over to the (potentially high-dimensional) stochastic domain. For this, we apply the introduced hierarchical basis WENO interpolation within a non-intrusive collocation method and present first results on 2- and 3-dimensional sparse grids.     

Dietary Apigenin Exerts Immune-Regulatory Activity in Vivo by Reducing NF-κB Activity,Halting Leukocyte Infiltration and Restoring Normal Metabolic Function

The increasing prevalence of inflammatory diseases and the adverse effects associated with the long-term use of current anti-inflammatory therapies prompt the identification of alternative approaches to reestablish immune balance. Apigenin, an abundant dietary flavonoid, is emerging as a potential regulator of inflammation. Here, we show that apigenin has immune-regulatory activity in vivo. Apigenin conferred survival to mice treated with a lethal dose of Lipopolysaccharide (LPS) restoring normal cardiac function and heart mitochondrial Complex I activity. Despite the adverse effects associated with high levels of splenocyte apoptosis in septic models, apigenin had no effect on reducing cell death. However, we found that apigenin decreased LPS-induced apoptosis in lungs, infiltration of inflammatory cells and chemotactic factors’ accumulation, re-establishing normal lung architecture. Using NF-κB luciferase transgenic mice, we found that apigenin effectively modulated NF-κB activity in the lungs, suggesting the ability of dietary compounds to exert immune-regulatory activity in an organ-specific manner. Collectively, these findings provide novel insights into the underlying immune-regulatory mechanisms of dietary nutraceuticals in vivo.