A survey on hygienic practices and their impact on the microbiological quality and safety in the Rwandan milk and dairy chain

This study assessed the status of hygienic practices in the Rwandan milk and dairy chain. Data collection was based on interviews with the help of a survey and site visits to farms, collection centres, milk processing companies, small‐scale cheese plants, wholesale points, supermarkets and milk shops. The observed status of good practices was further linked to actual microbiological data. It was concluded that there is a major gap in compliance with hygienic practices leading to higher levels of contaminated dairy products.     

The Signaling Role of CD40 Ligand in Platelet Biology and in Platelet Component Transfusion

The CD40 ligand (CD40L) is a transmembrane molecule of crucial interest in cell signaling in innate and adaptive immunity. It is expressed by a variety of cells, but mainly by activated T-lymphocytes and platelets. CD40L may be cleaved into a soluble form (sCD40L) that has a cytokine-like activity. Both forms bind to several receptors, including CD40. This interaction is necessary for the antigen specific immune response. Furthermore, CD40L and sCD40L are involved in inflammation and a panoply of immune related and vascular pathologies. Soluble CD40L is primarily produced by platelets after activation, degranulation and cleavage, which may present a problem for transfusion. Soluble CD40L is involved in adverse transfusion events including transfusion related acute lung injury (TRALI). Although platelet storage designed for transfusion occurs in sterile conditions, platelets are activated and release sCD40L without known agonists. Recently, proteomic studies identified signaling pathways activated in platelet concentrates. Soluble CD40L is a good candidate for platelet activation in an auto-amplification loop. In this review, we describe the immunomodulatory role of CD40L in physiological and pathological conditions. We will focus on the main signaling pathways activated by CD40L after binding to its different receptors.     

WorkSim: A Calibrated Agent-Based Model of the Labor Market Accounting for Workers’ Stocks and Gross Flows

This paper presents an agent-based model of the labor market. It simulates the market in the recent period at the aggregate level and at the level of the principal categories of labor, on the basis of the decisions of heterogeneous agents, firms and individuals, who interact. These decisions rely on individual computations of profits and utilities, although rationality is bounded in such a complex environment. The theoretical structure that underlies the decisions is the search concept. We apply this framework to the case of France in 2011. The model is at a scale of 1/4700. It is fairly detailed on the institutions of the labor market that constrain the agents’ decisions. Finally it is calibrated by a powerful algorithm to reproduce a large number of variables of interest. The calibrated model presents a consistent accounting system of the gross flows of the individuals between the main states, employment, distinguishing open ended contracts and fixed duration contracts, unemployment and inactivity. The simulation of the gross flows accounts enables us to analyze the patterns of mobility in a way that the observed statistics on gross flows, which are partial, cannot do. The model then characterizes the nature of the labor market under study, reproducing the high proportion of the fixed duration contracts in the hiring flows, and it points to a dualism of the French labor market.     

High‐Temperature Creep Behavior of SiOC Glass‐Ceramics: Influence of Network Carbon Versus Segregated Carbon

Three silicon oxycarbide samples with different carbon contents are analyzed in the present study with respect to their high‐temperature creep behavior. The tests were performed in compression at 1100°C, 1200°C, and 1300°C; in this temperature range the mechanism of creep relies on viscoelastic flow within the samples and has been modeled with the Jeffreys viscoelastic model. After the release of the applied mechanical stress, a viscoelastic recovery behavior was observed in all samples. The creep behavior of the investigated samples indicates two rheological contributions in SiOC: (i) a high viscous answer, coming from the silica‐rich network, and (ii) an elastic response from the segregated carbon phase within the samples. Furthermore, two distinct effects of the carbon phase on the HT creep behavior of SiOC were identified and are discussed in the present paper: the effect of the carbon presence within the SiOC network (the “carbidic” carbon), which induces a significant increase in the viscosity and a strong decrease in the activation energy for creep, as compared to vitreous silica; and the influence of the segregated carbon phase (the “free” carbon), which has been shown to affect the viscosity and the activation energy of creep and dominates the creep behavior in phase‐separated silicon oxycarbides.     

The impact of strain-induced crystallization on strain during mechanical cycling of cross-linked natural rubber

The improvement of X-ray diffraction techniques since the last ten years allowed a renewal of the study of strain-induced crystallization in natural rubber. In particular real-time measurements are now commonplace. However, due to experimental difficulties, the exploitation of the X-ray data as far as the strain state of the remaining molten fraction is concerned has been left aside. Indeed the knowledge of the local extension of the molten chains is crucial for understanding the peculiar stress behavior observed during the crystallization process. This paper presents a systematic study of this parameter during mechanical cycling performed at various temperatures. It is shown that crystallization limits the amplitude of strain endured by the molten fraction during traction. This process of strain regulation may be one explanation for the protective effect of crystallization against tearing. A precise evaluation of the contribution of the molten fraction to the retraction force during mechanical cycling is made. The role of crystallites as nanofillers may be quantified this way.     

Interpolation of rotation and motion

In Cosserat solids such as shear deformable beams and shells, the displacement and rotation fields are independent. The finite element implementation of these structural components within the framework of flexible multibody dynamics requires the interpolation of rotation and motion fields. In general, the interpolation process does not preserve fundamental properties of the interpolated field. For instance, interpolation of an orthogonal rotation tensor does not yield an orthogonal tensor, and furthermore, does not preserve the tensorial nature of the rotation field. Consequently, many researchers have been reluctant to apply the classical interpolation tools used in finite element procedures to interpolate these fields. This paper presents a systematic study of interpolation algorithms for rotation and motion. All the algorithms presented here preserve the fundamental properties of the interpolated rotation and motion fields, and furthermore, preserve their tensorial nature. It is also shown that the interpolation of rotation and motion is as accurate as the interpolation of displacement, a widely accepted tool in the finite element method. The algorithms presented in this paper provide interpolation tools for rotation and motion that are accurate, easy to implement, and physically meaningful.     

Shape‐Memory Topographies on Nickel–Titanium Alloys Trained by Embossing and Pulse Electrochemical Machining

The two‐way shape‐memory effect (TWSME) in Nickel–titanium (NiTi) alloys is of interest for applications in aerospace, biomedicine, and microengineering due to its reversible shape recovery. In this study, the authors demonstrate two approaches to obtain switchable surface structures using the TWSME. Samples are structured using two surface geometries by either cold embossing, or pulse electrochemical machining (PECM). After planarization, a change from optically smooth to structured and vice versa is observed. The switch is induced through heating and cooling the sample above and below the phase transformation temperature. The protrusions reflect the pattern applied by the two processes. Both methods are promising for preparation of switchable metallic surfaces on larger areas.