New boron analogues of pyrophosphates and deoxynucleoside boranophosphates

Tetraethyldicyanoborane pyrophosphate (2) and 3'-(diethylphosphite-cyanoborano)-5'-dimethoxytrityl.N(4)-benzoyl-deoxycytidine (3) have been synthesized in 70% and 76% yields, respectively. The compatibility of the substituted boranophosphates with common protecting groups is hereby demonstrated.Boron containing biologically active compounds, such as nucleosides and nucleotides (1-6) and amino acids (7-9) are important due to their potential therapeutic activity, research and diagnostic applications. Many boron containing compounds have shown promising activity as anticancer, (10.) (11.) (12) antiinflammatory,(13) and antiosteoporotic (13)agents. Oligonucleotdes in which a non-bridging oxygen atom is replaced by a borane(BH(3)) group are a very important class of modified nucleic acids. (1.) (3.) (14-16) The BH(3) group is isoelectronic with oxygen in natural oligonucleotides and isoelectronic and isostructural with the oligonucleotide methyl phosphonates, which are nuclease resistant. On the other hand, the alpha-borano triphosphates are good substrates for DNA polymerases and incorporation of boranophosphates into DNA causes an increase in the resistance to exo- and endonucleases (2.) (17a) as compared to non-modified DNA. There are also notable applications of the alpha-borano triphosphates in PCR sequencing (17a) and nucleic acid detection (17b).     

基于红旗linux DC的维、汉、英多语种操作系统的设计与实现

本文初步地介绍了红旗Linux DC的国际化,本地化的概念,并分析与研究了红旗Linux DC的国际化和本地化的方法和算法。     

Listening to Natural and Synthesized Speech while Driving: Effects on User Performance

The effects of message type (navigation, E-mail, news story), voice type (text-to-speech, natural human speech), and earcon cueing (present, absent) on message comprehension and driving performance were examined. Twenty-four licensed drivers (12 under 30, 12 over 65, both equally divided by gender) participated in the experiment. They drove the UMTRI driving simulator on a road consisting of straight sections and constant radius curves, thus yielding two levels of low driving-workload. In addition, as a control condition, data were collected while participants were parked. In all conditions, participants were presented with three types of messages. Each message was immediately followed by a series of questions to assess comprehension. Navigation messages were about 4 seconds long (about 9 words). E-mail messages were about 40 seconds long (about 100 words) and news messages were about 80 seconds long (about 225 words). For all message types, comprehension of text-to-speech messages, as determined by accuracy of response to questions, and by subjective ratings, was significantly worse than comprehension of natural speech (79 versus 83 percent correct answers; 7.7/10 versus 8.6/10 subjective rating). Driving workload did not affect comprehension. Interestingly, neither the speech used (synthesized or natural) nor the message type (navigation, E-mail, news) had a significant effect on basic driving performance measured by the standard deviations of lateral lane position and steering wheel angle.     

Wind energy in Sudan : Water pumping in rural areas

New and renewable sources of energy can make an increasing contribution to the energy supply mix of developing countries in view of favourable renewable energy resource endowments, limitations and uncertainties of fossil fuel supplies, adverse balance of payments, and the increasing pressure on the environment from conventional energy generation. Among the renewable energy technologies, the generation of mechanical and electric power by wind machines has emerged as an economically viable and cost effective option. Therefore the Sudanese government has begun to pay more attention to the use of wind energy in rural areas in particular as a cost-effective solution to assist in water pumping and irrigation.     

An optimal distributed solution to the dining philosophers problem

An optimal distributed solution to the dining philosophers problem is presented. The solution is optimal in the sense that it incurs the least communication and computational overhead, and allows the maximum achievable concurrency. The worst case upper bound for concurrency is shown to ben div 3,n being the number of philosophers. There is no previous algorithm known to achieve this bound.     

Physicochemical,thermal and pasting properties of starch separated from γ-irradiated and stored potatoes

The morphological, thermal and pasting properties of starch separated from potatoes of three varieties (Kufri Chandramukhi, Kufri Jyoti and Kufri Chipsona-2), treated either with CIPC (isopropyl N-(3 chlorophenyl) carbamate) or γ-irradiation (Co⁶⁰, 0.1 and 0.5 kGy) and subsequently stored at 8, 12 and 16 °C for 90 days, were studied. Scanning electron microscopy (SEM) showed the presence of oval and irregular shaped starch granules with a diameter range of 15–16 μm. Mean granule size of starch separated from potatoes stored at 12 °C ranged from 18–25 μm and irradiation treatment resulted in an increase in the proportion of small size granules. The irradiation of potatoes with 0.5 kGy resulted in starch with significantly lower peak-, trough- and breakdown-viscosity as compared to starch from potatoes treated with either CIPC or 0.1 kGy irradiation. The irradiation of potatoes with 0.5 kGy caused a significant increase in setback and pasting temperature. Pasting temperature of starch was observed to vary with the storage temperature. Starch separated from potatoes stored at higher temperature showed lower pasting temperature and vice versa. The starch from potatoes stored at 8 °C showed higher peak-, trough- and breakdown-viscosity and lower setback. Peak viscosity increased and swelling volume decreased with increase in storage temperature. FTIR spectra showed that the starch from irradiated potatoes displayed a significant decrease in the intensity of the C–H stretch region between 2800 and 3000 cm⁻¹, which was observed to be irradiation dose-dependent, and higher with 0.5 than 0.1 kGy. However, a slight broadening of O–H stretch (3000–3600 cm⁻¹) in starches from irradiated potatoes was observed. The spectral changes caused by γ-irradiation were apparent in the O–H stretch (3000–3600 cm⁻¹), C–H stretch (2800–3000 cm⁻¹) and bending mode of water (1600–1800 cm⁻¹).     

含氧化锆的氧化物系统计算相图研究与进展

氧化锆是一种重要的高性能陶瓷材料，由于其优良的力学和电学性能。在结构陶瓷和功能陶瓷两个都有着广泛的应用前景，本文在简述计算相图发展和原理的基础上，综述了近年来对含氧化锆系统计算相图的研究，总结了一些重要体系的研究结果，提出计算相图方法将对该系统材料的组分设计起重大的促进作用。     

Smart structures and their applications on active vibration control: Studies in the Department of Aerospace Engineering, METU

This work presents the theoretical and experimental studies conducted in Aerospace Engineering Department of Middle East Technical University on smart structures with particular attention given to the structural modelling characteristics and active suppression of in-vacuo vibrations. The smart structures considered in these analyses are finite and flat aluminium cantilever beam-like (called as smart beam) and plate-like (called as smart fin) structures with surface bonded lead–zirconate–titanate patches. Finite element models of smart beam and smart fin are obtained. Then the experimental studies regarding open loop behaviour of the structures are performed by using strain gauges and laser displacement sensor to determine the system models. Further studies are carried out to obtain H _∞ and μ-synthesis controllers which are intended to be used in the suppression of free and forced vibrations of the smart structures. It is observed that satisfactory attenuation levels are achieved and robust performance of the systems in the presence of uncertainties is ensured. In that respect a comparative study involving H _∞ and sliding mode controls is also conducted. Recently, the studies involving aerodynamic loading are also gathering pace.