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151.
Ana Rita Gomes Nasim Bahram Sangani Tiago G. Fernandes M. Margarida Diogo Leopold M. G. Curfs Chris P. Reutelingsperger 《International journal of molecular sciences》2020,21(24)
The central nervous system (CNS) is the most complex structure in the body, consisting of multiple cell types with distinct morphology and function. Development of the neuronal circuit and its function rely on a continuous crosstalk between neurons and non-neural cells. It has been widely accepted that extracellular vesicles (EVs), mainly exosomes, are effective entities responsible for intercellular CNS communication. They contain membrane and cytoplasmic proteins, lipids, non-coding RNAs, microRNAs and mRNAs. Their cargo modulates gene and protein expression in recipient cells. Several lines of evidence indicate that EVs play a role in modifying signal transduction with subsequent physiological changes in neurogenesis, gliogenesis, synaptogenesis and network circuit formation and activity, as well as synaptic pruning and myelination. Several studies demonstrate that neural and non-neural EVs play an important role in physiological and pathological neurodevelopment. The present review discusses the role of EVs in various neurodevelopmental disorders and the prospects of using EVs as disease biomarkers and therapeutics. 相似文献
152.
Brusov V. S. Korchagin P. O. Malyshev V. V. Piyavsky S. A. 《Journal of Computer and Systems Sciences International》2020,59(1):83-94
Journal of Computer and Systems Sciences International - The article considers the problem of making multicriteria decisions in which the decision maker (DM) has the opportunity to indicate the... 相似文献
153.
Pavel Strunz Debashis Mukherji Přemysl Beran Ralph Gilles Lukas Karge Michael Hofmann Markus Hoelzel Joachim Rösler Gergely Farkas 《Metals and Materials International》2018,24(5):934-944
An addition of boron largely increases the ductility in polycrystalline high-temperature Co–Re alloys. Therefore, the effect of boron on the alloy structural characteristics is of high importance for the stability of the matrix at operational temperatures. Volume fractions of ε (hexagonal close-packed—hcp), γ (face-centered cubic—fcc) and σ (Cr2Re3 type) phases were measured at ambient and high temperatures (up to 1500 °C) for a boron-containing Co–17Re–23Cr alloy using neutron diffraction. The matrix phase undergoes an allotropic transformation from ε to γ structure at high temperatures, similar to pure cobalt and to the previously investigated, more complex Co–17Re–23Cr–1.2Ta–2.6C alloy. It was determined in this study that the transformation temperature depends on the boron content (0–1000 wt. ppm). Nevertheless, the transformation temperature did not change monotonically with the increase in the boron content but reached a minimum at approximately 200 ppm of boron. A probable reason is the interplay between the amount of boron in the matrix and the amount of σ phase, which binds hcp-stabilizing elements (Cr and Re). Moreover, borides were identified in alloys with high boron content. 相似文献
154.
Nano crystalline pure and Mg doped ceriaparticles were synthesized by simple chemical co-precipitation method using cerium nitrate hexahydrate as a source material and magnesium nitrate as doping precursor at room temperature. The effect of doping were investigated by X-ray diffraction pattern(XRD), FT-Raman,fourier transform infrared spectroscopy(FTIR), Ultraviolet spectroscopy(UV), photoluminescence spectroscopy(PL), field emission scanning electron microscope(FESEM) and high resolution transmission electron microscopy with energy dispersive spectroscopy (HRTEM &EDS). The X-ray diffraction pattern and FT-Raman studies showed that the prepared samples were nano particulates with cubic fluorite structure. The XRD pattern analysis showed that the size of the particles ranged from 13 to 20?nm, however 4?wt% Mg doping results in reduction of particle size compared with other doping concentrations. The effects of Mg concentration on various structural parameters of the prepared samples were also determined. The slight blue shift observed upon doping in UV–Vis absorption region around 330–360nmrecorded for reduction in particle size. The FTIR unveils the presence of Metal oxygen bonds below 700?cm?1in the prepared samples. All samples showed a broad emission band at 430?nm with linearly increasing intensity with respect to dopant concentrations. The Spherical morphology with weak agglomeration was identified through FESEM and HRTEM analysis. The elemental analysis of Ce, O and Mg were confirmed through EDS analysis. 相似文献
155.
156.
The dynamic interaction between the mechanical and electrical drive parameters when damage suddenly appears in the mechanical part of a conveyer belt is investigated. The possibility of using the change in the motor’s electrical parameters as a diagnostic signal is assessed. A model for investigating the dynamic processes in the system consisting of the grid, the induction motor, and the conveyer belt is proposed. The grid and induction motor are described by a model of fourth-order state space, whose output is the torque at the motor shaft. The moments of inertia and pliability of the links between the elements in the mechanical part of the conveyer belt are determined. By gradually identifying the elements with the minimum moment of inertia and distributing their moments of inertia and pliabilities among the adjacent elements, we obtain a three-mass system simulating the mechanical part of the conveyer belt. This dynamic model is solved by means of Matlab Simulink software. The energy characteristics of the drive are determined in dynamic processes following a mechanical accident. 相似文献
157.
158.
K.M. Srinivasamurthy Jagadeesha Angadi V S.P. Kubrin Shiddaling Matteppanavar D.A. Sarychev P. Mohan Kumar Haileeyesus Workineh Azale B. Rudraswamy 《Ceramics International》2018,44(8):9194-9203
Ferrites may contain single domain particles which gets converted into super-paramagnetic state near critical size. To explore the existence of these characteristic feature of ferrites, we have performed magnetization(M-H loop) and Mössbauer spectroscopic studies of Ni2+ substitution effect in Co1-xNixFe2O4 (where x?=?0, 0.25, 0.5, 0.75 and 1) nanoparticles were fabricated by solution combustion route using mixture of carbamide and glucose as fuels for the first time. As prepared samples exhibit spinel cubic structure with lattice parameters which decreases linearly with increase in Ni2+ concentration. The M-H loops reveals that saturation magnetization(Ms), coercive field(Hc) remanence magnetization(Mr) and magnetron number(ηB) decreases significantly with increasing Ni2+ substitution. The variation of saturation magnetization has been explained on the basis of Neel's molecular field theory. The coercive field(Hc) is found strongly dependent on the concentration of Ni2+ and decrease of coercivity suggests that the particles have single domain and exhibits superparamagnetic behavior. The Mössbauer spectroscopy shows two ferrimagnetically relaxed Zeeman sextets distribution at room temperature. The dependence of Mössbauer parameters such as isomer shift, quadru pole splitting, line width and hyperfine magnetic field on Ni2+ concentration have been discussed. Hence our results suggest that synthesized materials are potential candidate for power transformer application. 相似文献
159.
An agriglass composition containing different oxides acts as a slow release for macro and micro nutrients and was chosen to improve maize yield under most important abiotic stresses which affecting agriculture development; salinity and drought. A field experiment was performed in salt affected soil (EC =?7.5 dSm??1) by using different water deficit rates (I1 = 100, I2 = 85 and I3 = 70% of maize water requirements). Irrigation levels were located in main plots. Every main-plot divided into six sub-plots contained glassy fertilizer treatments [F1 = 55 kg fed?1 with 1/2 mm diameter of agriglass (fed. =?4200 m2), F2 = 55 kg fed?1 with 1 mm diameter, F3 = 80 kg fed?1 with 1/2 mm diameter, F4 = 80 kg fed?1 with 1 mm diameter, F5 = Recommendations of Ministry of Agriculture and F6 = control]. The experimental results demonstrated that, ears, straw, grains and biological yields increased with increasing both water and agriglass rates. Application of agriglass as a slow release fertilizer improved yield more than mineral fertilizer. Some growth parameters, water use efficiency (IWUE), macronutrients concentration and their relations were included. Other studies on residual effect of agriglass and the annual application rates to withstand salinity and drought stress by strategic crops are required. 相似文献
160.