A SAS macro for target dose estimation by reinforced urn processes in phase I clinical trials

The reinforced urn processes (RUPs) approach can estimate the target dose on the basis of the prior distribution function precisely and conveniently without the requirements about the explicit-estimated dose-response curve and the posterior complicated inference. The application of the RUPs approach was not discussed from the perspective of phase I clinical trial in the previous studies which just focused on the theory and methodology. And the modification of the traditional RUPs design should be considered for the purposes of ethnics and efficiency. A SAS macro was designed to explore the appropriate parameter settings according to the simulation outcomes in different situations and apply the RUPs approach for two state processes in phase I clinical trail with the modified RUPs design. The posterior estimation can be obtained precisely and efficiently with application of SAS program following the appropriate workflow and determination rule which were described in the example.     

一种多约束的密度聚类算法的研究

针对传统的密度聚类算法不能处理带有多约束条件的问题,在现有的密度聚类算法的基础上,提出了一个带有多约束条件限制的密度聚类算法。该算法将多约束条件引入到密度聚类分析中,并分析了多约束条件对聚类结果的影响。实验表明该算法在多约束条件下,可有效完成对数据点的聚类并且效果较好,为现实情况中处理多约束聚类提供了良好的理论支持。     

On spam detection based on cognitive pattern recognition

A method of spam detection, based on cognitive pattern recognition, had been proposed. The connection between Email category and cognition of Email user interest within life and work, had been analyzed. Under the guidance of cognitive pattern recognition theory, the mechanism of spam detection, based on intelligent cognition of Email user interest within life and work, had been discussed. Then the spam detection algorithm and its concrete implementation was given. Experimental results demonstrate that the spare detection algorithm has a good learning ability, scalability, and a good ability to achieve high recognition accuracyn     

一种网络多点备份系统的设计和实现

该文提出并实现了一种网络多点备份系统。通过在本地应用服务器的设备驱动层之上加入写监控驱动,所有写操作将被封装成备份记录并发往本地缓存网关暂存,然后由本地缓存网关异步地将备份记录发送到多个处于不同地域的远程备份网关,最后在远程备份网关上重建写操作。该系统实现了对本地数据的多点异地备份,能够适应多种网络状况,支持Linux下所有文件系统和物理存储设备     

小波变换在交通参数检测中的应用

针对视频交通图像的特点,提出了一种将灰度判断与边缘检测相结合来检测交通参数的方法;综合了灰度检测和边缘检测的优点,采用帧平均法来处理视频流,可以减小由于摄像头抖动或背景微小变化而产生的误差;分析了小波变换的特点,应用小波变换对交通图像进行车辆边缘检测,对不同尺度小波变换后的水平方向、垂直方向和对角线方向的高频信息,用互能量交叉的方法进行噪声抑制,突出主要边缘,最后,在车辆边缘识别基础上获得车流量、车速等相关交通参数;实验结果表明,此方法简单、有效,获得了较满意的检测结果。     

一种基于缆索的堆石混凝土堆石入仓方式及应用

堆石入仓主要解决的是堆石垂直、水平、上下游方向的三维运输问题,基于安徽大龙潭水库拱坝除险加固工程的应用实例,介绍了一种基于缆索的堆石混凝土堆石入仓方式,包括设备构造和堆石流程。经过对比分析该堆石入仓方式与塔吊堆石入仓方式、长臂挖机堆石入仓方式的运行效率和成本,得出结论:基于缆索的堆石入仓方式适用于不具备自卸汽车入仓条件、工期较长、施工速度要求不高的堆石混凝土施工。     

双级贯流式水轮机导叶和转轮的水力设计

针对一种新型双级贯流式水轮机,推导了一级导叶、一级转轮、二级导叶和二级转轮的参数设计公式。利用数值模拟商业软件Fluent分析了水轮机在设计工况下的数值性能。数值计算时控制方程采用雷诺时均N-S离散方程,湍流模型选择标准k-ε模型,得到了水轮机的流线图、导叶和转轮叶片的压力面和吸力面的压力分布图,以及中心对称面x=0.083 5的速度矢量图,数值计算结果证明了水轮机设计的正确性。     

基于SMW工法的城市深基坑开挖稳定性分析

SMW工法具有防渗性好、构造简单、施工速度快、工程造价低等优点,广泛应用于大型隧道工程、城市地下空间开发、高层建筑深基坑开挖支护工程等。以某城市深基坑工程的SMW工法围护结构为研究对象,在考虑水泥土与型钢的相互作用下,建立有限元数值模型,分析开挖过程中墙体位移和土体变形特点。结果表明:开挖深度对墙体侧向位移有显著影响;随着坡面荷载的增加,基坑内外水平方向和竖直方向沉降量均有所增大。     

Infections due to Lancefield group F and related Streptococci (S. milleri, S. anginosus)

We can no longer accept classification of streptococci solely on the basis of hemolytic reactions or Lancefield agglutinations. While the "viridans" streptococci cannot be serologically differentiated, physiological separation of the species offers a satisfactory method of classifying human isolates. We review the microbiology of Lancefield group F and related streptococci (S. milleri, S. anginosus), emphasizing microbial ecology and current taxonomic considerations. A series of 28 patients infected with these organisms is presented. There was a striking male predominance in the series (6:1) as well as an obvious association with underlying diseases and/or antecedent trauma. The most remarkable feature of these pathogens is their predilection for abscess formation, confirming their overdue recognition as the most common "viridans" streptococcus recovered from abscesses within internal organs. We observed purulent disease of the nervous and skeletal systems, oral cavity, lung and pleural space, abdomen and subcutaneous tissues. Microbial synergy (i.e. polymicrobic infection) was not a requisite for abscess formation. Four of the five deaths in this series occurred in patients 60 years of age of older. Some degree of variability in antimicrobial susceptibility was noted, so speciation alone may not always provide sufficient information on which to base a therapeutic decision.     

On promoting dispersion and intercalation of bentonite in high density polyethylene by grafting vinyl triethoxysilane

Vinyl triethoxysilane grafted high density polyethylene (HDPE-g-YDH151)/Bentonite (BT) composites were prepared via melt compounding and compared with HDPE/BT composites. FTIR proved that HDPE-g-YDH151 is chemically bonded to BT sheets. XRD, SEM and TEM results indicated that the introduction of YDH151 promoted the dispersion and intercalation of BT into HDPE. Consequently, HDPE-g-YDH151/BT composites show satisfied mechanical properties, e.g., the composite with 2phr BT has an elongation at break 29% higher and Young’s modulus 32% higher than that of HDPE-g-YDH151.Comparatively, BT aggregated in HDPE/BT composites and all the mechanical properties decreased. Because of high interfacial adhesion between HDPE-g-YDH151 matrix and exfoliated BT, which reduces the mobility of crystallizable PE chain segments, and subsequently reduces the crystallization ability. In comparison, the addition of BT to HDPE did not affect the crystallization behavior of the later.