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71.
72.
Pei-Fang Hung Fa-Po Chung Chung-Lieh Hung Yenn-Jiang Lin Tzu-Ting Kuo Jo-Nan Liao Yun-Yu Chen Chih-Hsin Pan Kai-Ping Shaw Shih-Ann Chen 《International journal of molecular sciences》2022,23(10)
Arrhythmogenic right ventricular cardiomyopathy (ARVC) is a hereditary disease of the heart muscle. Clinical challenges remain, however, in identifying patients with ARVC in the early or concealed stages with subtle clinical manifestations. Therefore, we wanted to identify potential targets by immunohistochemical (IHC) analysis in comparison with controls. Pathogenic mutations were identified in 11 of 37 autopsied patients with ARVC. As observed from IHC analysis of the RV, expression of αT-catenin and plakophilin-2 is significantly decreased in autopsied patients with ARVC as compared to controls, and the decreased expression is consistent in patients with and without pathogenic mutations. Furthermore, ARVC specimens demonstrated a reduced localization of αT-catenin, desmocollin-2, desmoglein-2, desmoplakin, and plakophilin-2 on intercalated discs. These findings have been validated by comparing RV specimens obtained via endomyocardial biopsy between patients with ARVC and those without. The pathogenic mutation was present in 3 of 5 clinical patients with ARVC. In HL-1 myocytes, siRNA was used to knockdown CTNNA3, and western blotting analysis demonstrated that the decline in αT-catenin expression was accompanied by a significant decline in the expression of plakophilin-2. The aforementioned effect was directed towards protein degradation rather than mRNA stability. Plakophilin-2 expression decreases concurrently with the decline in CTNNA3 expression. Therefore, the expression of αT-catenin and plakophilin-2 could be potential surrogates for the diagnosis of ARVC. 相似文献
73.
Editable Supercapacitors with Customizable Stretchability Based on Mechanically Strengthened Ultralong MnO2 Nanowire Composite 下载免费PDF全文
Zhisheng Lv Yifei Luo Yuxin Tang Jiaqi Wei Zhiqiang Zhu Xinran Zhou Wenlong Li Yi Zeng Wei Zhang Yanyan Zhang Dianpeng Qi Shaowu Pan Xian Jun Loh Xiaodong Chen 《Advanced materials (Deerfield Beach, Fla.)》2018,30(2)
Although some progress has been made on stretchable supercapacitors, traditional stretchable supercapacitors fabricated by predesigning structured electrodes for device assembling still lack the device‐level editability and programmability. To adapt to wearable electronics with arbitrary configurations, it is highly desirable to develop editable supercapacitors that can be directly transferred into desirable shapes and stretchability. In this work, editable supercapacitors for customizable shapes and stretchability using electrodes based on mechanically strengthened ultralong MnO2 nanowire composites are developed. A supercapacitor edited with honeycomb‐like structure shows a specific capacitance of 227.2 mF cm?2 and can be stretched up to 500% without degradation of electrochemical performance, which is superior to most of the state‐of‐the‐art stretchable supercapacitors. In addition, it maintains nearly 98% of the initial capacitance after 10 000 stretch‐and‐release cycles under 400% tensile strain. As a representative of concept for system integration, the editable supercapacitors are integrated with a strain sensor, and the system exhibits a stable sensing performance even under arm swing. Being highly stretchable, easily programmable, as well as connectable in series and parallel, an editable supercapacitor with customizable stretchability is promising to produce stylish energy storage devices to power various portable, stretchable, and wearable devices. 相似文献
74.
Yan-Fang Zhang Jinbo Pan Huta Banjade Jie Yu Hsin Lin Arun Bansil Shixuan Du Qimin Yan 《Nano Research》2021,(3):584-589
We propose a novel class of two-dimensional(2D)Dirac materials in the MX family(M=Be,Mg,Zn and Cd,X=Cl,Br and I),which exhibit graphene-like band structures with linearly-dispersing Dirac-cone states over large energy scales(0.8–1.8 eV)and ultra-high Fermi velocities comparable to graphene.Spin-orbit coupling opens sizable topological band gaps so that these compounds can be effectively classified as quantum spin Hall insulators.The electronic and topological properties are found to be highly tunable and amenable to modulation via anion-layer substitution and vertical electric field.Electronic structures of several members of the family are shown to host a Van-Hove singularity(VHS)close to the energy of the Dirac node.The enhanced density-of-states associated with these VHSs could provide a mechanism for inducing topological superconductivity.The presence of sizable band gaps,ultra-high carrier mobilities,and small effective masses makes the MX family promising for electronics and spintronics applications. 相似文献
75.
The rapid development of biophotonics and biomedical sciences makes a high demand on photonic structures to be interfaced with biological systems that are capab... 相似文献
76.
77.
Weiti Cui Zihan Zhuang Peihao Jiang Jincheng Pan Gan Zhao Sheng Xu Wenbiao Shen 《International journal of molecular sciences》2022,23(14)
Cinnamoyl-CoA reductase (CCR) is a pivotal enzyme in plant lignin synthesis, which has a role in plant secondary cell wall development and environmental stress defense. Alfalfa is a predominant legume forage with excellent quality, but the lignin content negatively affects fodder digestibility. Currently, there is limited information on CCR characteristics, gene expression, and its role in lignin metabolism in alfalfa. In this study, we identified 30 members in the CCR gene family of Medicago sativa. In addition, gene structure, conserved motif, and evolution analysis suggested MsCCR1–7 presumably functioned as CCR, while the 23 MsCCR-likes fell into three categories. The expression patterns of MsCCRs/MsCCR-likes suggested their role in plant development, response to environmental stresses, and phytohormone treatment. These results were consistent with the cis-elements in their promoters. Histochemical staining showed that lignin accumulation gradually deepened with the development, which was consistent with gene expression results. Furthermore, recombinant MsCCR1 and MsCCR-like1 were purified and the kinetic parameters were tested under four substrates. In addition, three-dimensional structure models of MsCCR1 and MsCCR-like1 proteins showed the difference in the substrate-binding motif H212(X)2K215R263. These results will be useful for further application for legume forage quality modification and biofuels industry engineering in the future. 相似文献
78.
79.
阐述了如何利用Java消息服务和心跳技术实现对分散模块状态的监控,以及保证模块间通信无阻。通过收发消息的形式,集中监控关键模块,并准确定位故障所在,尽可能保证系统长时间的无故障运作。 相似文献
80.
星环形计算机局域网的性能研究 总被引:2,自引:0,他引:2
本文结合星形(Star)和环形(Ring)拓扑结构,提出了一种全新的LAN(Local Area Network)结构——星环形LAN.它以较低廉的代价在网络的几个主要性能指标上获得较大的提高.本文论述了星环形LAN(StarRing LAN)的设计思想和各性能指标的研究结果. 相似文献