MEMS lubricants based on bound and mobile phases of hydrocarbon compounds: film deposition and performance evaluation

The concept of a thin layer of mobile hydrocarbon-based lubricant providing protection by replenishment to a surface already protected by a chemically bound material has been explored for the first time, for application to silicon-based microelectromechanical (MEMS) systems. Several bound/mobile pairs of lubricants were evaluated to study the effects of bound phase end group and mobile phase chemical functionality on wettability and performance. The bound species studied were derived from 1-decanol and 1,7-heptanediol. Mobile phases investigated were, a pentaerythritol ester, a multiply alkylated cyclopentane, Pennzane, and a polysilane developed for spacecraft application. Hydrocarbon lubricant performance was evaluated using electrostatic motors run in dry air, and was compared with that provided by Fomblin Zdol under identical conditions. Motors with hydrocarbon coatings showed substantial improvement in performance over uncoated motors, and for some bound/mobile pairs, was equal to Zdol within experimental error. We believe that for silicon-based devices, hydrocarbon coatings will be preferable at least for some applications, as the degradation observed due to aging of a fluorinated lubricant in direct contact with a silicon surface is absent.     

The combinatorial design approach to automatic test generation

The combinatorial design method substantially reduces testing costs. The authors describe an application in which the method reduced test plan development from one month to less than a week. In several experiments, the method demonstrated good code coverage and fault detection ability     

Outcome of long-term enteral feeding

In the past two decades, many technical advances have made tube enteral feeding much more comfortable and acceptable to patients and their families. This has greatly expanded the use of this therapy, both in clinical conditions where it was traditionally prescribed and in many other diagnoses. This expanded use raises important questions about how much enteral nutrition is being used, the medical outcome in different clinical conditions, and the quality of life experienced by long-term therapy users. This article addresses these outcome issues for patients in the nonhospital setting.     

Screening calcaneal ultrasound and risk factors for osteoporosis among lesbians and heterosexual women

We compared calcaneal ultrasound measurements (speed of sound [SOS], broadband ultrasound attenuation [BUA], and stiffness index [SI]) of lesbian and heterosexual women to examine the medical and lifestyle risk factors for osteoporosis in each group. This was an exploratory, community-based, cross-sectional study. Subjects were mailed food frequency, health, and physical activity questionnaires. Weight, height, and calcaneal ultrasound measurements were taken at one office visit. In communities in southern and eastern Maine, 71 lesbians and 77 heterosexual women between the ages of 30 and 50 with regular menses and in good general health were the subjects. Statistical analysis used t-tests and chi-square tests to evaluate differences between study groups. Linear regression models were used to evaluate risk factors for low calcaneal ultrasound measurements. There were no differences between the lesbian and heterosexual women in age, body mass index (BMI), exercise, calcium intake, alcohol use, or calcaneal ultrasound measurements. There was a positive association between BUA and both BMI and alcohol consumption (p < 0.01). Antidepressant use significantly reduced SOS and SI (p < 0.05). There were no differences in calcaneal ultrasound measurements between lesbian and heterosexual women. BMI was strongly and positively associated with BUA. Antidepressant use in both populations was associated with a significant reduction in calcaneal bone mass. Studies are needed to define the relationship of depression and its treatment to bone mineral density and the future risk of osteoporosis.     

Moderating effects of client attachment on the counselor experience–working alliance relationship.

The authors predicted that client attachment status would moderate the relationship between counselor experience and client-perceived working alliance. Forty clients from 2 university counseling centers completed measures of attachment and the working alliance. Their counselors were classified according to experience level. Client comfort with intimacy was related to a stronger alliance with the counselors. However, counselor experience was unrelated to client-rated working alliance. Client attachment, specifically comfort with intimacy, moderated the relationship between counselor experience and working alliance. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Change of Writing Style with Time

This study investigates the writing stylechange of two Turkish authors, Çetin Altanand Yaar Kemal, in their old and newworks using respectively their newspapercolumns and novels. The style markers are thefrequencies of word lengths in both text andvocabulary, and the rate of usage of mostfrequent words. For both authors, t-tests andlogistic regressions show that the length ofthe words in new works is significantly longerthan that of the old. The principal componentanalyses graphically illustrate the separationbetween old and new texts. The works arecorrectly categorized as old or new with 75 to100% accuracy and 92% average accuracy usingdiscriminant analysis-based cross validation. The results imply higher time gap may havepositive impact in separation andcategorization. For Altan a regressionanalysis demonstrates a decrease in averageword length as the age of his column increases. One interesting observation is that for oneword each author has similar preference changesover time.     

Understanding User Centricity

Building useful software relies on understanding users, their goals, and their problems, and on determining the software that will help them reach those goals and solve those problems. User centricity isn't just caring about users or asking them what they want. It's understanding them and collaborating effectively with them to help make informed choices about what software to build.     

Daunorubicin‐Loaded DNA Origami Nanostructures Circumvent Drug‐Resistance Mechanisms in a Leukemia Model

Many cancers show primary or acquired drug resistance due to the overexpression of efflux pumps. A novel mechanism to circumvent this is to integrate drugs, such as anthracycline antibiotics, with nanoparticle delivery vehicles that can bypass intrinsic tumor drug‐resistance mechanisms. DNA nanoparticles serve as an efficient binding platform for intercalating drugs (e.g., anthracyclines doxorubicin and daunorubicin, which are widely used to treat acute leukemias) and enable precise structure design and chemical modifications, for example, for incorporating targeting capabilities. Here, DNA nanostructures are utilized to circumvent daunorubicin drug resistance at clinically relevant doses in a leukemia cell line model. The fabrication of a rod‐like DNA origami drug carrier is reported that can be controllably loaded with daunorubicin. It is further directly verified that nanostructure‐mediated daunorubicin delivery leads to increased drug entry and retention in cells relative to free daunorubicin at equal concentrations, which yields significantly enhanced drug efficacy. Our results indicate that DNA origami nanostructures can circumvent efflux‐pump‐mediated drug resistance in leukemia cells at clinically relevant drug concentrations and provide a robust DNA nanostructure design that could be implemented in a wide range of cellular applications due to its remarkably fast self‐assembly (≈5 min) and excellent stability in cell culture conditions.     

Robust fault detection using Luenberger-type unknown input observers-a parametric approach

A new parametric observer-based approach for robust fault detection in multivariable linear systems with unknown disturbances is proposed. The residual is generated through utilizing a Luenberger function observer. By using a parametric solution to a class of generalized Sylvester matrix equations, a parametrization is proposed for the residual generator on the basis of a Luenberger function observer. By further properly constraining the design parameters provided in the Luenberger observer design, the effect of the unknown disturbance is decoupled from the residual signal. The proposed approach provides all the degrees of freedom and is demonstrated to be simple and effective.     

Mixed time- and frequency-domain robust eigenstructure assignment

This paper considers robust eigenstructure assignment for multivariable systems. The time-domain performance specifications provided by eigenstructure assignment and robust performance specifications in the frequency domain considered by H infinity control are combined to realize joint optimal robust control design. A parametric expression for state-feedback eigenstructure assignment is introduced on the basis of a set of free parameters. The mixed performance index used as the cost function consists of two parts: robustness in the frequency domain; and system eigenstructure constraints in the time domain. The analytical gradient calculation of the cost function with respect to the free parameters is derived for optimal robust eigenstructure assignment using gradientbased optimization. The mixed time- and frequency-domain robust eigenstructure assignment is demonstrated in the design of a mode-decoupled roll-yaw autopilot.