Will the numbers add up for sub-7-nm magnetic spacings? Future metrology issues for disk drive lubricants, overcoats, and topographies

To achieve disk drive recording densities greater than one terabit per square inch, future head-media spacings (HMSs) will need to be less than 7 nm. This will place severe demands on the metrology tools used to measure the thickness and topographies of the contributors to the head-media spacing. Here, we first review some of the metrologies used for characterizing overcoats, lubricants, and topographies and discuss some of the limits that will make it difficult to achieve a sub-7-nm HMS. We next show new results for measuring lubricant redistribution on disk surfaces after contact with a small pad on the slider and present a new method for determining wear rates of these slider contact pads.     

Noise characteristics of erbium-doped fiber amplifier pumped at 980nm

A noise figure of 2.9±0.4 dB, measured in a high-gain erbium-doped fiber amplifier for input signals in the range -35 to -15 dBm and for pump powers of >5.8 mW, is discussed. The spontaneous emission factor n_sp was 0.99±0.09 for input signals less than -15 dBm. These low figures are attributable to the optimized fiber design and the use of a pump wavelength of 980 nm, at which erbium operates as a true three-level system. These two factors contribute to the very low (~500 μW) pump threshold seen in fiber, which permits nearly complete inversion to be achieved for the low pump powers employed     

The effect of scene elevation on the coherence of wide-angle crossing-node SAR pairs

The interference between two radar images, acquired from approximately the same location, has a number of uses. In particular, the literature abounds with examples of coherent change detection (CCD) and interferometric synthetic aperture radar (InSAR) uses that, respectively, enable the detection of small changes and the extraction of terrain elevation. In almost all of these examples, collections have been deliberately constrained so that they have almost identical collection geometries. Details of the variation in geometry have been analyzed extensively but generally only with respect to variation in the mean grazing angle. Much of this variation is due to the angular variation in the scene reflectivity; however, when collection geometries differ in other respects, the reduction in performance cannot be entirely explained by angular variations alone. This paper identifies a source of performance degradation when the collection geometries are different for scenes containing local relief. The error is due to approximations during image formation that both the collection geometry and the terrain are flat. The effect of these errors is derived as a blurring kernel to the true scene. The impact of the blurring is then assessed in the interferometric case and broken into common and differential blurring terms to facilitate the impact of some special cases and to explain why the parallel-pass geometry works as well as it does even though the true three-dimensional nature of the collection and the ground are ignored.     

Pervasive information — the key to ‘true’ mobility

Since Weiser’s vision in 1991 for ubiquitous (also called pervasive) computing there has been little tangible progress towards it. However, over time the communications industry has begun to erode many of the hardware barriers to this vision. Even so, the utopia of pervasive computing remains out of reach, primarily as a result of the continued fixation with devices and connectivity as a way to realise mobility. However, it could be argued that users ultimately require access to information or content irrespective of the devices and connectivity around them. Consequently, pervasive information is seen as the key to true user mobility. This paper will introduce a potential secure pervasive information architecture that fits Weiser’s vision, and position it with respect to a sub-set of current contenders for future systems from both academia and the telecommunications industry, and highlight their strengths and weaknesses.     

Biospecific Self‐Assembly of a Nanoparticle Coating for Targeted and Stimuli‐Responsive Drug Delivery

Biology provides a range of materials, mechanisms, and insights to meet the diverse requirements of nanomedicine. Here, a biologically based nanoparticle coating system that offers three characteristic features is reported. First, the coating can be self‐assembled through a noncovalent biospecific interaction mechanism between a lectin protein (Concanavalin A) and the polysaccharide glycogen. This biospecific self‐assembly enables the coating to be applied simply without the generation of covalent bonds. Second, glycoprotein‐based biofunctionality can be incorporated into the coating through the same noncovalent biospecific interaction mechanism. Here, the glycoprotein transferrin is incorporated into the coating since this moiety is commonly used to target cancer cells through a receptor‐mediated endocytosis mechanism. Third, the coating can be triggered to disassemble in response to a reduction in pH that is characteristic of endosomal uptake. In a proof‐of‐concept study, comparing coated and uncoated nanoparticles, model drug‐loaded nanoparticles (doxorubicin‐loaded mesoporous silica nanoparticles) are prepared and it is observed that the coated nanoparticle has enhanced cytotoxicity for cancer cell lines but attenuated cytotoxicity for noncancerous cell lines. These studies demonstrate that biology provides unique materials and mechanism appropriate to meet the needs for emerging applications in the medical and life sciences.     

Uranium sorption on various forms of titanium dioxide--influence of surface area, surface charge, and impurities

Titanium dioxide (TiO(2)) has often served as a model substrate for experimental sorption studies of environmental contaminants. However, various forms of Ti-oxide have been used, and the different sorption properties of these materials have not been thoroughly studied. We investigated uranium sorption on some thoroughly characterized TiO(2) surfaces with particular attention to the influence of surface area, surface charge, and impurities. The sorption of U(VI) differed significantly between samples. Aggressive pretreatment of one material to remove impurities significantly altered the isoelectric point, determined by an electroacoustic method, but did not significantly impact U sorption. Differences in sorption properties between the various TiO(2) materials were related to the crystallographic form, morphology, surface area, and grain size, rather than to surface impurities or surface charge. In-situ attenuated total reflection Fourier-transform infrared (ATR FT-IR) spectroscopic studies showed that the spectra of the surface species of the TiO(2) samples are not significantly different, suggesting the formation of similar surface complexes. The data provide insights into the effect of different source materials and surface properties on radionuclide sorption.     

Preliminary evaluation of endogenous milk fluorophores as tracer molecules for curd syneresis

A front-face fluorescence spectroscopy probe was installed in the wall of a laboratory-scale cheese vat. Excitation and emission filters were chosen for the selective detection of vitamin A, tryptophan, and riboflavin fluorescence. The evolution of the fluorescence of each fluorophore during milk coagulation and syneresis was monitored to determine if they had the potential to act as intrinsic tracers of syneresis and also coagulation. The fluorescence profiles for 2 of the fluorophores during coagulation could be divided into 3 sections relating to enzymatic hydrolysis of κ-casein, aggregation of casein micelles, and crosslinking. A parameter relating to coagulation kinetics was derived from the tryptophan and riboflavin profiles but this was not possible for the vitamin A response. The study also indicated that tryptophan and riboflavin may act as tracer molecules for syneresis, but this was not shown for vitamin A. The evolution of tryptophan and riboflavin fluorescence during syneresis followed a first-order reaction and had strong relationships with curd moisture and whey total solids content (r = 0.86-0.96). Simple 1- and 2-parameter models were developed to predict curd moisture content, curd yield, and whey total solids using parameters derived from the sensor profiles (standard error of prediction = 0.0005-0.394%; R² = 0.963-0.999). The results of this study highlight the potential of tryptophan and riboflavin to act as intrinsic tracer molecules for noninvasive inline monitoring of milk coagulation and curd syneresis. Further work is required to validate these findings under a wider range of processing conditions.     

Hypermnesia for pictures and words: Testing the recall level hypothesis.

Five experiments with 150 undergraduates examined the hypothesis that hypermnesia (improved recall across repeated tests) can be predicted from cumulative recall levels. Contrary to this view, Exp I demonstrated that when the cumulative recall levels for pictures and words were equated, pictures still produced a larger hypermnesic effect. Results of Exps II and III show that varying test length (and thus recall level) had no effect on the magnitude of the hypermnesic effect. In Exp IV, Ss studied a categorized word list and then received 1 21-min test or 3 7-min tests. Results suggest that (a) similar retrieval processes are used in these 2 conditions and (b) hypermnesia in the repeated test paradigm results from Ss generating covert cues to aid item recovery across tests. Overall findings suggest that although hypermnesia is related to cumulative recall levels, various other factors (e.g., item type) modulate the magnitude of the hypermnesia by affecting item accessibility across tests. It is argued that changes in item accessibility across tests, caused by learning during testing, play a major role in producing hypermnesia in both episodic and semantic memory tasks. (43 ref) (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

A stereoselective cobalt-containing nitrile hydratase

Nitrile hydratase from Pseudomonas putida NRRL-18668 has been purified and characterized. The purified enzyme catalyzes the hydration of 2(S)-(4'-chlorophenyl)-3-methylbutyronitrile at least fifty times faster than that of 2(R)-(4'-chlorophenyl)-3-methylbutyronitrile. This enzyme is a member of the class of nitrile hydratase that contains cobalt. Visible absorption and CD spectra suggest the cobalt exists as a non-corrin low-spin Co3+ ion in a tetragonally-distorted octahedral ligand field. Chemical reduction of the native enzyme results in a species with the EPR signature of a low-spin Co2+ complex. Like the other cobalt-containing nitrile hydratases, this enzyme is relatively stable, maintaining its activity below 35 degrees C, and it shows a broad activity optimum between pH 7.2 and 7.8. The structural genes for this enzyme have been cloned and sequenced. The deduced amino acid sequences for the alpha and beta subunits show 48-63% and 35-41% homology, respectively, to other sequenced nitrile hydratases. In particular, the cysteine residues in the alpha subunit that have been suggested to coordinate the metal ion in the iron-containing nitrile hydratases [Brennan, B. A., Cummings, J. G., Chase, D. B., Turner, I. M., Jr., & Nelson, M. J. (1996) Biochemistry 35, 10068-10077] are conserved in this enzyme, suggesting that this nitrile hydratase, like the enzyme from Rhodococcus rhodochrous J1, is a member of a newly described class of metalloenzymes with Co3+-thiolate ligation [Brennan, B. A., Alms, G., Nelson, M. J., Durney, L. T., & Scarrow, R. C. (1996) J. Am. Chem. Soc. 118, 9194-9195].     

Visual discrimination by cats given lesions of visual cortex in one or two stages in infancy or in one stage in adulthood.

Sparing of visual function was studied in cats with bilateral cortical damage to Areas 17 and 18 and most of Area 19. Cats with lesions made in 2 stages, on Postnatal (P) Days 3 and 6, in 1 stage on P6, or in 1 stage in adulthood were compared with sham-operated controls on 10 visual discrimination tasks. On some tasks, both groups of cats that underwent surgery as infants showed considerable sparing of function compared with cats that had surgery as adults; the latter group showed a marked impairment. However, on several of the discriminations, 2-stage lesions permitted almost total sparing of pattern vision, whereas 1-stage lesions made neonatally were almost as debilitating as those incurred in adulthood. The findings suggest that differential behavioral consequences can follow physiological or anatomical changes, or both, that occur within a 4-day neonatal interoperative period. (PsycINFO Database Record (c) 2010 APA, all rights reserved)