Hana Kokot  Boštjan Kokot  Aleksandar Sebastijanović  Carola Voss  Rok Podlipec  Patrycja Zawilska  Trine Berthing  Carolina Ballester-López  Pernille Høgh Danielsen  Claudia Contini  Mikhail Ivanov  Ana Krišelj  Petra Čotar  Qiaoxia Zhou  Jessica Ponti  Vadim Zhernovkov  Matthew Schneemilch  Zahra Doumandji  Mojca Pušnik  Polona Umek  Stane Pajk  Olivier Joubert  Otmar Schmid  Iztok Urbančič  Martin Irmler  Johannes Beckers  Vladimir Lobaskin  Sabina Halappanavar  Nick Quirke  Alexander P. Lyubartsev  Ulla Vogel  Tilen Koklič  Tobias Stoeger  Janez Štrancar 《Advanced materials (Deerfield Beach, Fla.)》2020,32(47):2003913

On a daily basis, people are exposed to a multitude of health-hazardous airborne particulate matter with notable deposition in the fragile alveolar region of the lungs. Hence, there is a great need for identification and prediction of material-associated diseases, currently hindered due to the lack of in-depth understanding of causal relationships, in particular between acute exposures and chronic symptoms. By applying advanced microscopies and omics to in vitro and in vivo systems, together with in silico molecular modeling, it is determined herein that the long-lasting response to a single exposure can originate from the interplay between the newly discovered nanomaterial quarantining and nanomaterial cycling between different lung cell types. This new insight finally allows prediction of the spectrum of lung inflammation associated with materials of interest using only in vitro measurements and in silico modeling, potentially relating outcomes to material properties for a large number of materials, and thus boosting safe-by-design-based material development. Because of its profound implications for animal-free predictive toxicology, this work paves the way to a more efficient and hazard-free introduction of numerous new advanced materials into our lives.  相似文献   

    

N. Krog 《Starch - St?rke》1973,25(1):22-27

The influence of monoglycerides (DGMS), stearoyl-2-lactylates (CSL, SSL), and diacetylated tartaric acid esters of monoglycerides (DATE) on amylograph curves of various starches has been investigated. DGMS gave the greatest increase in pasting temperature of wheat and tapioca starch, followed by SSL, CSL and DATE. The pasting temperature of corn and potato starch was less affected by these emulsifiers. Peak viscosity of wheat starch in distilled water was increased by all emulsifiers, and was decreased in tapioca and potato starch. Both pasting temperature and peak viscosity were strongly influenced by variations in pH, and were to some extent also dependent on ion concentration. In hard tap water the peak viscosity was slightly decreased by the anionic emulsifiers (SSL > CSL > DATE), due to the presence of Ca⁺⁺ and Mg⁺⁺ ions, while DGMS gave a higher peak viscosity than in distilled water. DATE seems to be more sensitive to variations in pH or ion concentration than the other emulsifiers.  相似文献