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971.
    
With the increasing usage of drugs to remedy different diseases, drug safety has become crucial over the past few years. Often medicine from several companies is offered for a single disease that involves the same/similar substances with slightly different formulae. Such diversification is both helpful and dangerous as such medicine proves to be more effective or shows side effects to different patients. Despite clinical trials, side effects are reported when the medicine is used by the mass public, of which several such experiences are shared on social media platforms. A system capable of analyzing such reviews could be very helpful to assist healthcare professionals and companies for evaluating the safety of drugs after it has been marketed. Sentiment analysis of drug reviews has a large potential for providing valuable insights into these cases. Therefore, this study proposes an approach to perform analysis on the drug safety reviews using lexicon-based and deep learning techniques. A dataset acquired from the ‘Drugs.Com’ containing reviews of drug-related side effects and reactions, is used for experiments. A lexicon-based approach, Textblob is used to extract the positive, negative or neutral sentiment from the review text. Review classification is achieved using a novel hybrid deep learning model of convolutional neural networks and long short-term memory (CNN-LSTM) network. The CNN is used at the first level to extract the appropriate features while LSTM is used at the second level. Several well-known machine learning models including logistic regression, random forest, decision tree, and AdaBoost are evaluated using term frequency-inverse document frequency (TF-IDF), a bag of words (BoW), feature union of (TF-IDF + BoW), and lexicon-based methods. Performance analysis with machine learning models, long short term memory and convolutional neural network models, and state-of-the-art approaches indicate that the proposed CNN-LSTM model shows superior performance with an 0.96 accuracy. We also performed a statistical significance T-test to show the significance of the proposed CNN-LSTM model in comparison with other approaches.  相似文献   
972.
    
The continuous use of chemical dyes in various industries, and their discharge into industrial effluents, results in severe problems to human life and water pollution. Laccases have the ability to decolorize dyes and toxic chemicals in industrial effluents as green biocatalysts. Their possible industrial applications have been limited by poor reusability, low stability, and loss of free laccase action. In this research, laccase was immobilized on zeolitic imidazolate framework coated multi-walled carbon nanotubes (Laccase@ZIF-8@MWCNTs) via metal affinity adsorption to develop an easy separable and stable enzyme. The optimum reaction conditions for immobilized laccase are at a pH of 3.0 and a temperature of 60?℃. The immobilized laccase was enhanced in storage and thermal stability. The results indicated that Laccase@ZIF-8@MWCNTs still maintained 68% of its original activity after 10 times of repeated use. Most importantly, the biocatalytic system was applied for decolorization of different dyes (20?mg·L?1) without a mediator, and up to 97.4% for Eriochrome black T and 95.6% Acid red 88 was achieved in 25 min. Biocatalysts with these properties may be used in a variety of environmental and industrial applications.  相似文献   
973.
974.
Schoenlein-Henoch purpura is characterized clinically by palpable purpura, mainly on the legs, with varying degrees of gastrointestinal, articular and renal involvement. Renal involvement is often more severe in the adult than in children and it often determines the outcome of the disease. Schoenlein-Henoch purpura is also characterized by an IgA-vasculitis, which may be triggered by several non-specific antigenic factors. Its pathogenesis is still unclear, but a dysfunction of the IgA immune system has been demonstrated. We discuss the anatomo-clinical, therapeutic and etiopathogenic aspects of this syndrome according to today's knowledge.  相似文献   
975.
976.
This article presents the numerical implementation of an elastoplastic behavior model suitable for estimating the damage produced when excavating galleries in deep argilite layers. The main rheological features of the model are related to post-peak behavior, brittle fracture, softening and dilatancy effects. Damage of the rock may increase significantly the hydraulic permeability and vice versa. We focus on numerical difficulties such as suitable calculations for plastic flow at very low confinement levels and those resulting from following the confinement factor in such a way that the algorithms converge until physical collapse. The numerical results obtained with a 2D simulation are in good agreement with generally observed phenomena. Dilatancy produces instantaneous cohesion, which disappears with time. Increasing permeability speeds up this tendency.  相似文献   
977.
Pilot‐plant studies on the treatment of three wastewaters (biological aerated flooded filter (BAFF) backwash water, post‐primary settling tank effluent and BAFF effluent) have been conducted using a ballasted sedimentation process (ACTIFLO®) coupled with ferric chloride and polyaluminium chloride (PACl) coagulants. The response of the process to shock loads of high solids concentrations was also investigated. Results showed over 80% turbidity, 70% suspended solids, and 50% COD removals to be achievable at rise rates in excess of 80 m h?1 and dose rates of 10–20 mg dm?3 Fe. Slightly improved performance was attained using PACL at half the weight concentration (but about the same molar concentration) as that of Fe. No pH adjustment was necessary and process performance was not significantly influenced by changes in hydraulic loading rate. Effluent quality was largely unaffected by shock organic loads provided coagulant dosing was commensurately increased. Non‐ideal flow through the plant was apparent from the measured residence time, which was ~25% less than that calculated for plug flow. Clarification data were comparable to those reported for other high‐rate clarification (HRC) processes, with somewhat improved performance in terms of hydraulic retention time and coagulant use. Copyright © 2004 Society of Chemical Industry  相似文献   
978.
Lower and upper bounds for the mixed capacitated arc routing problem   总被引:2,自引:0,他引:2  
This paper presents a linear formulation, valid inequalities, and a lower bounding procedure for the mixed capacitated arc routing problem (MCARP). Moreover, three constructive heuristics and a memetic algorithm are described. Lower and upper bounds have been compared on two sets of randomly generated instances. Computational results show that the average gaps between lower and upper bounds are 0.51% and 0.33%, respectively.  相似文献   
979.
980.
The comparability of the MMPI-2 in American Indians with the MMPI-2 normative group was investigated in a sample of 535 Southwestern and 297 Plains American Indian tribal members with contrasting sociocultural and historical origins. Both American Indian tribal groups had clinically significant higher T scores (>5 T points) on 5 validity and clinical scales, 6 content scales, and 2 supplementary scales than did the MMPI-2 normative group. There were no significant differences between the 2 tribal groups on any of the MMPI-2 clinical, content, or supplementary scales. Matching members of both tribes with persons in the MMPI-2 normative group on the basis of age, gender, and education reduced the magnitude of the differences between the 2 groups on all of these scales, although the differences in T scores still exceeded 5 T points. It appears likely that the MMPI-2 differences of these 2 American Indian groups from the normative group may reflect their adverse historical, social, and economic conditions. (PsycINFO Database Record (c) 2010 APA, all rights reserved)  相似文献   
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