Measurement of fractional order model parameters of respiratory mechanical impedance in total liquid ventilation

This study presents a methodology for applying the forced-oscillation technique in total liquid ventilation. It mainly consists of applying sinusoidal volumetric excitation to the respiratory system, and determining the transfer function between the delivered flow rate and resulting airway pressure. The investigated frequency range was f ∈ [0.05, 4] Hz at a constant flow amplitude of 7.5 mL/s. The five parameters of a fractional order lung model, the existing "5-parameter constant-phase model," were identified based on measured impedance spectra. The identification method was validated in silico on computer-generated datasets and the overall process was validated in vitro on a simplified single-compartment mechanical lung model. In vivo data on ten newborn lambs suggested the appropriateness of a fractional-order compliance term to the mechanical impedance to describe the low-frequency behavior of the lung, but did not demonstrate the relevance of a fractional-order inertance term. Typical respiratory system frequency response is presented together with statistical data of the measured in vivo impedance model parameters. This information will be useful for both the design of a robust pressure controller for total liquid ventilators and the monitoring of the patient's respiratory parameters during total liquid ventilation treatment.     

Bi-exponential edge-preserving smoother

Edge-preserving smoothers need not be taxed by a severe computational cost. We present, in this paper, a lean algorithm that is inspired by the bi-exponential filter and preserves its structure-a pair of one-tap recursions. By a careful but simple local adaptation of the filter weights to the data, we are able to design an edge-preserving smoother that has a very low memory and computational footprint while requiring a trivial coding effort. We demonstrate that our filter (a bi-exponential edge-preserving smoother, or BEEPS) has formal links with the traditional bilateral filter. On a practical side, we observe that the BEEPS also produces images that are similar to those that would result from the bilateral filter, but at a much-reduced computational cost. The cost per pixel is constant and depends neither on the data nor on the filter parameters, not even on the degree of smoothing.     

Maximum Likelihood-Based Direction-of-Arrival Estimator for Discrete Sources

This paper addresses the problem of direction-of-arrival (DOA) parameter estimation in array processing when the signals are inherently discrete, which is the case mainly in the digital communication context. Based on the particular structure of the signal space in the data model, a maximum likelihood-based approach is introduced. The strategy consists in transforming the parameter estimation problem into a decision task. It is shown through numerical simulations that the proposed solution closely follows the performance limit given by the Cramér–Rao bound. Some important features of the technique are as follows: (i) it is capable of handling any number of sources, provided that the number of sensors is greater than or equal to two and the number of snapshots is sufficiently greater than the cardinality of the signal space; (ii) the estimation quality is not affected by the angle and phase separation; and (iii) it offers the possibility to deal with uncalibrated arrays.     

Floating Point CGRA based Ultra-Low Power DSP Accelerator

Journal of Signal Processing Systems - Coarse Grained Reconfigurable Arrays (CGRAs) are emerging as energy efficient accelerators providing a high grade of flexibility in both academia and...     

A 3.3 V, 10 Bits, Clock-Feedthrough Compensated Switched-Current Second Order Sigma-Delta Modulator

This article presents a low-pass sigma-delta modulator for Analogue-to-Digital conversion. The circuit uses a switched-current technique which presents a well known drawback called clock feedthrough. This phenomenon induces an error on the output signal value. In order to cancel the clock feedthrough effect, we use a new method based on a current feedback loop. The circuit is designed in 0.8 μm AMS “Austria Mikro Systems” single poly CMOS process. Measurements of the modulator are performed under A/D converters characterisation system, and show 55 dB dynamic range at 2.048 MHz sampling rate with 8 kHz input frequency bandwidth. These characteristics are suitable for audio applications.     

Quantitative coherent anti-Stokes Raman scattering microspectroscopy using a nanosecond supercontinuum light source

We describe and characterize a multiplex CARS microspectroscopic system that uses a nanosecond supercontinuum generated from a photonic crystal fiber and a sub-nanosecond pulse laser. This system has a high spectral resolution (<0.1 cm^?1) and an ultrabroadband spectral coverage (>2500 cm^?1). The estimated spatial resolutions are 0.45 μm (lateral) and 4.5 μm (axial), respectively. This system enables us to obtain CARS spectra and corresponding images in the fingerprint region as well in the CH stretch region. Using this system, we have successfully obtained label-free and multi-mode vibrational images of a yeast cell.     

优秀人才缺乏导致大起大落欧洲教训为移动运营商敲响警钟

移动运营商在过去的12年中经历了一个爆发性增长的“火山期”和一个低增长的-一冰河期”。起落之间反映的是运营商在人才上的缺失,这一来自欧洲电信市场上的教训值得全球所有运营商警惕。     

Cell‐Tethered Ligands Modulate Bone Remodeling by Osteoblasts and Osteoclasts

The goals of the present study are to establish an in vitro co‐culture model of osteoblast and osteoclast function and to quantify the resulting bone remodeling. The bone is tissue engineered using well‐defined silk protein biomaterials in 2D and 3D formats in combination with human cells. Parathyroid hormone (PTH) and glucose‐dependent insulinotropic peptide (GIP) are selected because of their roles in bone remodeling for expression in tethered format on human mesenchymal stem cells (hMSCs). The cell‐modified biomaterial surfaces are reconstructed from scanning electron microscopy images into 3D models for quantitative measurement of surface characteristics. Increased calcium deposition and surface roughness are found in 3D surface models of silk protein films remodeled by co‐cultures containing tethered PTH, and decreased surface roughness is found for the films remodeled by tethered GIP co‐cultures. Increased surface roughness is not found in monocultures of hMSCs expressing tethered PTH, suggesting that osteoclast‐osteoblast interactions in the presence of PTH signaling are responsible for the increased mineralization. These data point towards the design of in vitro bone models in which osteoblast‐osteoclast interactions are mimicked for a better understanding of bone remodeling.     

5G meets satellite: Non-terrestrial network architecture and 3GPP

With 3GPP Release-17, global 5G standards now support non-terrestrial mobile networks comprising radio access network, terminals, and core network. This enables multi-vendor interoperability as well as interoperability with 3GPP-compliant 5G systems. This paper describes the key features enabling the NG-RAN architecture defined for 5G to support non-terrestrial networks. Starting from a general overview of NG-RAN and of the new paradigms of NTN, we introduce the NTN functionality in NG-RAN specifications with respect to feeder link switchover, cell handling, terminal registration, and OAM aspects. We also discuss different scenarios combining satellite access with 3GPP-defined core networks. We also describe some further enhancements expected to be seen in the next 3GPP release (Rel-18). We believe current and upcoming 3GPP work for NTN represents a solid basis on which 5G satellite networks can be built in the upcoming future.     

Energy Efficient Hardware Loop Based Optimization for CGRAs

Journal of Signal Processing Systems - Research interest and industry investment in edge computing solutions have increased dramatically in recent years. Consequent quest for balanced performance,...