Intratumoral Thermal Reading During Photo‐Thermal Therapy by Multifunctional Fluorescent Nanoparticles

The tremendous development of nanotechnology is bringing us closer to the dream of clinical application of nanoparticles in photothermal therapies of tumors. This requires the use of specific nanoparticles that must be highly biocompatible, efficient light‐to‐heat converters and fluorescent markers. Temperature reading by the heating nanoparticles during therapy appears of paramount importance to keep at a minimum the collateral damage that could arise from undesirable excessive heating. In this work, this thermally controlled therapy is possible by using Nd³⁺ ion‐doped LaF₃ nanocrystals. Because of the particular optical features of Nd³⁺ ions at high doping concentrations, these nanoparticles are capable of in vivo photothermal heating, fluorescent tumor localization and intratumoral thermal sensing. The successful photothermal therapy experiments here presented highlight the importance of controlling therapy parameters based on intratumoral temperature measurements instead of on the traditionally used skin temperature measurements. In fact, significant differences between intratumoral and skin temperatures do exist and could lead to the appearance of excessive collateral damage. These results open a new avenue for the real application of nano­particle‐based photothermal therapy at clinical level.     

A multimode CMOS PA with a single propagation path

Analog Integrated Circuits and Signal Processing - In this paper a four mode 130 nm RF CMOS power amplifier (PA) in a single propagation path topology is presented and evaluated with IEEE...     

A Tutorial on Multiplierless Design of FIR Filters: Algorithms and Architectures

Finite impulse response (FIR) filtering is a ubiquitous operation in digital signal processing systems and is generally implemented in full custom circuits due to high-speed and low-power design requirements. The complexity of an FIR filter is dominated by the multiplication of a large number of filter coefficients by the filter input or its time-shifted versions. Over the years, many high-level synthesis algorithms and filter architectures have been introduced in order to design FIR filters efficiently. This article reviews how constant multiplications can be designed using shifts and adders/subtractors that are maximally shared through a high-level synthesis algorithm based on some optimization criteria. It also presents different forms of FIR filters, namely, direct, transposed, and hybrid and shows how constant multiplications in each filter form can be realized under a shift-adds architecture. More importantly, it explores the impact of the multiplierless realization of each filter form on area, delay, and power dissipation of both custom (ASIC) and reconfigurable (FPGA) circuits by carrying out experiments with different bitwidths of filter input, design libraries, reconfigurable target devices, and optimization criteria in high-level synthesis algorithms.     

MnO2-Based Electrochemical Supercapacitors on Flexible Carbon Substrates

Manganese dioxide films were grown on large area flexible carbon aerogel substrates. Characterization by x-ray diffraction confirmed α-MnO₂ growth. Three types of films were compared as a function of hexamethylenetetramine (HMTA) concentration during growth. The highest concentration of HM TA produced MnO₂ flower-like films, as observed by scanning electron microscopy, whose thickness and surface coverage lead to both a higher specific capacitance and higher series resistance. Specific capacitance was measured to be 64 F/g using a galvanostatic setup, compared to the 47 F/g-specific capacitance of the carbon aerogel substrate. Such supercapacitor devices can be fabricated on large area sheets of carbon aerogel to achieve high total capacitance.     

Cooking- and juiciness-related quality characteristics of goat and sheep meat

Significant differences exist between the quality characteristics of meat obtained from 27 sheep, Angora and Boer goat carcases, when compared. Sheep meat showed greater drip loss than goat meat and was more juicy than that of Angora and Boer goat meat. In general, Angora goat meat was found to be more juicy than Boer goat meat. Drip loss increased significantly with increased animal age. Meat of younger animals (no permanent incisors) was more juicy (initial and sustained) than that of older animals (7–8 permanent incisors). This was irrespective of whether it was obtained from sheep, Angora or Boer goats and was confirmed by the expressible moisture measurements. Higher drip, evaporation and total cooking loss were reported when carcases had increased fat content. With increasing fatness of carcases, the juiciness of the cooked cuts decreased and the expressible moisture content of the meat increased.     

Spreading Codes Generator for Wireless CDMA Networks

The prime characteristic of spread spectrum modulated signals is that their bandwidth is greater than the information rate. In this way a redundancy is introduced that allows the severe levels of inteference inherent in the transmission of digital information over radio and satellite links to be overcome. Current spread spectrum applications are primarily in military communications; nevertheless, there is growing interest in this technique for third generation mobile radio networks (UMTS, FPLTS, etc.) with open discussion regarding the practicality of using a multiple access system based on spread spectrum techniques (CDMA). However, in order to support as many users in the same bandwidth as other multiple access techniques such as TDMA or FDMA, it is important how to generate large families of sequences that present low cross-correlation. The aim of this paper is to describe a spreading codes generator that can produce a large number of PN sequences with good properties of auto- and cross-correlation. Moreover, the codes generated shows high unpredictability and good statistical behaviour. This also allows the implementation of some features that are common on military networks such as message privacy (increasingly important in commercial networks) without additional cost. The structure presented shows itself to be advantageous for high speed generation of codes at a low cost, low power consumption (allowing longer life for batteries), small size and simplicity of implementation, essential ingredients for commercial equipment. Another attractive feature is its structural parallelism, useful in VLSI implementations. All of these features render it potentially suitable for the implementation of channel bandwidth sharing systems in future wireless personal communications networks.     

A High Voltage Line Driver for Subscriber Loop Interfaces in a Low Voltage Submicron BiCMOS Technology

This paper presents a 30 V line driver for short loop subscriber line interface circuit applications. The high voltage line drivers was implemented in a low-voltage 0.8 m BiCMOS process using 30 V extended-drain MOS transistors, fully compatible with the low voltage technology. Using a Quasi-Current Mirror architecture for the output stage, the line driver is capable of delivering more than 30 mA current into the lines with an idle current as low as 1 mA, satisfying the short loop requirements. With less than 0.24 mm² area, the circuit can be easily integrated with low-voltage circuitry on a single chip.     

Microwave active resonator band-pass filters in various mmic technologies

In this article, two topologies of L-C parallel active resonators are presented. These circuits are realized in MMIC technology, using three transistors which could be MESFET, hemt or HBT. The survey of these resonators shows the possibility, by controling the values of a resistor and/or a capacitor, on the one hand, to tune the resonance frequency of these circuits, and on the other hand, to cancel out their losses so as to obtain negative conductance. Compact, lossless and narrow-band filters are then implemented using previous active resonators. To date, the use of mesfet technology has reduced the synthesis of such active filters in S-band and at X-band low frequencies. Now, however, hemt and HBT technologies allow the extension of their implementation to the whole X-band. This survey is illustrated by the simulated response of a 10 GHz filter with a 500 MHz 3 dB bandwidth. The mmic technology is a 0.2 μm hemt one. The simulated performances of this filter achieve a mean transmission gain of 0. 5 dB, with a reflection loss higher than 10 dB at 10 GHz,     

Boundary scan test,test methodology,and fault modeling

The test technique called boundary scan test (BST) offers new opportunities in testing but confronts users with new problems too. The implementation of BST in a chip has become an IEEE standard and users on board level are the next group to begin thinking about using the new possibilities. This article addresses some of the questions about changes in board-level testing and fault diagnosis. The fault model itself is also affected by using BST. Trivial items are extended with more sophisticated details in order to complete the fault model. Finally, BST appears to be a test technique that offers a high degree of detectability on board level, but for diagnosis, some additional effort has to be made.