Apoptotic Effects of Chrysin in Human Cancer Cell Lines

Chrysin is a natural flavonoid currently under investigation due to its important biological anti-cancer properties. In most of the cancer cells tested, chrysin has shown to inhibit proliferation and induce apoptosis, and is more potent than other tested flavonoids in leukemia cells, where chrysin is likely to act via activation of caspases and inactivation of Akt signaling in the cells. Moreover, structure-activity relationships have revealed that the chemical structure of chrysin meets the key structural requirements of flavonoids for potent cytotoxicity in leukemia cells. It is possible that combination therapy or modified chrysin could be more potent than single-agent use or administration of unmodified chrysin. This study may help to develop ways of improving the effectiveness of chrysin in the treatment of leukemia and other human cancers in vitro.     

Handoff performance analysis of PMIPv6-based distributed mobility management protocol-urban scenario

Mobility management allows the networks to track down a mobile user's location for sending datagrams and to retain the connection when the user changes its location points repeatedly. Whenever a node switches between one base station and another, the connectivity is maintained through a process called handoff management. For real-time traffic implementations in wireless network communications, handover performance is essential. A mobile node is blocked from transmitting and receiving a datagram for a longer time as the handover delay increases. Unacceptable handover delays are common in real-time communication services. To guarantee smooth connectivity and continuous provision of services, effective handoff methods are required. The handoff efficiency of network-based distributed mobility management (DMM) is studied extensively in this article, along with a comparison to PMIPv6. We specifically investigate how handover delay, session recovery, and packet loss are influenced by cell radius. From the analytical and simulation findings this paper concludes that network-based DMM performs better than PMIPv6.