BILEAT: a highly generalized and robust approach for unified aspect-based sentiment analysis

Applied Intelligence - Aspect-based sentiment analysis (ABSA) includes two subtasks, namely, aspect term extraction and aspect-level sentiment classification. Most existing works address these...     

3-substituted 2-phenylimidazo[2,1-b]benzothiazoles: synthesis, anticancer activity, and inhibition of tubulin polymerization

A new series of 3‐substituted 2‐phenylimidazo[2,1‐b]benzothiazoles ( 3 a – h ) were synthesized by C‐arylation of 2‐arylimidazo[2,1‐b]benzothiazoles using palladium acetate as catalyst, and the resulting compounds were evaluated for their anticancer activity. Compounds 3 a , 3 e , and 3 h exhibited good antiproliferative activity, with GI₅₀ values in the range of 0.19–83.1 μM . Compound 3 h showed potent anticancer efficacy against 60 human cancer cell lines, with a mean GI₅₀ value of 0.88 μM . This compound also induced cell‐cycle arrest in the G₂/M phase and inhibited tubulin polymerization followed by activation of caspase‐3 and apoptosis. A high‐throughput tubulin polymerization assay showed that the level of inhibition for compound 3 h is similar to that of combretastatin A‐4. Molecular modeling studies provided a molecular basis for the favorable binding of compounds 3 a , 3 e , and 3 h to the colchicine binding pocket of tubulin.     

Polycaprolactone-blended gelatin microspheres and their morphological study

Polycaprolactone (PCL)-blended gelatin microspheres were prepared in the size ranges of 5–20 μm as well as 70–340 μm and modified through different compositions of PCL to gelatin in the oil-in-water emulsion solvent evaporation method. The formation of the polymer particles and particle morphology, stability, crystallinity, and thermal behavior of the polymer blends were studied. The changes in physiochemical properties of the blends were also studied with the addition of very less amount of polyvinylpyrrolidone (PVP), as it enhances the particle size distribution of microspheres as well as the surface morphology. Differential scanning calorimetry analysis shows the shifting of exothermic peak in the PCL/gelatin blend, and the PCL/gelatin blend stabilized by PVP results in the decrease in crystallinity. PCL-blended gelatin microspheres were smooth with definite shape and fine dispersibility with the increased concentration of gelatin to the polymer while lower concentration of the gelatin caused agglomeration. Optimization of the gelatin and PVP ratio to the polymer matrix results in large-size spherical stable microparticles. The stabilizing ability of microsphere decreases with the increased concentration of PCL during the solvent evaporation method. The addition of PVP to the PCL/gelatin blend enhanced the particle size distribution of microspheres as well as the surface morphology.