Chronic interleukin-6 alters NMDA receptor-mediated membrane responses and enhances neurotoxicity in developing CNS neurons

Recent studies show that the cytokine interleukin-6 (IL-6) is expressed at elevated levels in the CNS in several disease states and contributes to the neuropathological process. The mechanisms through which IL-6 exerts its CNS effects are primarily unknown. We have investigated the pathophysiological effects of IL-6 on developing CNS neurons using a culture model system and a chronic treatment paradigm. Here, we show, using current- and voltage-clamp recordings, that chronic IL-6 treatment of developing cerebellar granule neurons increases the membrane and current response to NMDA and that these effects are the primary mechanism through which IL-6 produces an enhanced calcium signal to NMDA. We also show that calcium influx through voltage-sensitive calcium channels contributes to the enhanced calcium signal to NMDA in the IL-6-treated neurons in a developmentally regulated manner and that the membrane depolarization to NMDA is more sensitive to the NMDA receptor antagonist ifenprodil in the IL-6-treated neurons compared with control neurons at a late developmental stage, consistent with a larger proportion of NMDA receptors containing the NMDAR2B subunit in the IL-6-treated neurons. Additional studies show that IL-6 treatment reduces the number of granule neurons in culture and enhances neurotoxicity involving NMDA receptors. These results support a pathological role for IL-6 in the CNS and indicate that NMDA receptor-mediated functions are likely to play a critical role in neuropathological changes observed in CNS diseases associated with elevated CNS levels of IL-6.     

TiO_2对ZrO_2－NiCr金属陶瓷烧结特性和相稳定性的影响

本文研究了ＴｉＯ２掺入对ＣａＯ稳定ＺｒＯ２（简称ＣａＳＺ－ＮｉＣｒ）金属陶瓷烧结特性的影响，测定了ＣａＳＺ－ＮｉＣｒ－ＴｉＯ２金属陶瓷烧结样品的密度和显微硬度，结果表明，ＴｉＯ２的掺入能提高ＣａＳＺ－ＮＩＣｒ金属陶瓷的烧结密度和显微硬度，对ＣａＳＺ－ＮｉＣｒ金属陶瓷有助烧结作用．金相观察表明，ＴｉＯ３的掺入改变了ＮｉＣｒ相在金属陶瓷中的形貌，说明了ＮｉＣｒ与ＣａＳＺ的浸润性有一定的改善．ＸＲＤ和ＥＰＭＡ分析结果显示，ＴｉＯ２偏聚在ＮｉＣｒ金属相中，不影响ＣａＳＺ的稳定性．     

基于C#的电子文档管理系统

鉴于工作中积累了各种各样的文件,数量多、存储分散,易造成文档查找困难等问题,设计了办公电子文档管理系统,实现了资料管理、资料查阅、用户管理、打印管理和系统管理功能。实用管理的功能保证了文档资料能够最大化实现其价值,作为科研人员有力的参考资料。     

光催化降解废气过程中紫外辐射照度模拟和优化

为在光催化设计中合理布置紫外灯,减少光在传输过程中的损失,概括总结径向辐射模型、多点源叠加近似辐射模型和离散坐标辐射模型等3种经典的紫外辐射物理模型;基于离散坐标辐射模型模拟某公司生产的光催化氧化废气处理装置的紫外辐射照度;通过调整灯管布置距离改变光强分布,并拟合光催化单元和光催化网表面的平均紫外辐射照度随灯管布置距离变化曲线.结果表明,距离参数在55～65 mm时,该光催化反应装置的光能利用率较好;紫外灯的合理布置可有效提高光能利用率.     

AdaFuse: Adaptive Multiview Fusion for Accurate Human Pose Estimation in the Wild

International Journal of Computer Vision - Occlusion is probably the biggest challenge for human pose estimation in the wild. Typical solutions often rely on intrusive sensors such as IMUs to...     

坦克炮控系统摩擦扰动补偿研究

针对坦克水平向炮控伺服系统中存在的摩擦不确定因素及未建模动态,首先建立水平向炮控伺服系统的数学模型,将摩擦扰动和未建模动态视为一个综合扰动项,然后利用扩张状态观测器对综合扰动项进行观测和补偿,并将扩张状态观测器(ESO)补偿回路作为经典PID控制方法的内回路,实现ESO-PID的复合控制;最后对所用方法进行仿真,结果表明,在原有控制方法的基础上设计控制器,集合了PID控制算法的"被动抗扰"和自抗扰控制方法中扩张状态观测器的"主动抗扰"特性,能够在保持控制系统原有特性的基础上大幅度提高炮控系统的稳定精度以及低速性能。     

一种基于软件无线电的中频数字接收机的设计实现

中频数字接收机是随着数字信号处理技术的不断发展而成熟起来的;此文主要是基于软件无线电的思想,采用MATLAB和DSP相结合的新颖开发方法,利用MATLAB-DSP集成开发环境Embedded Target for the TI TMS320C6000DSP Platform,从Simulink模型自动生成TIC6000DSP的可执行代码,从而缩短了DSP算法软件的研发周期;文中的输入信号是AM调制信号,采样率为1.6MHz,调制信号为2kHz,载波为400kHz,经过128倍抽取和滤波,最后输出数据流速率为12.5kHz;通过仿真实验证明,采用软件无线电的思想不仅满足了设计需求,而且增强了不同系统之间的互通性、兼容性、灵活性和可靠性,同时降低了成本。     

开源自动化控制软件Sedona在物联网中的应用

通过讨论物联网的现状、关键技术及发展方向,主要介绍了一种开源自动化控制软件Sedona在物联网的应用技术,包括在物联网架构中如何进行软件开发和应用程序设计,并介绍了该架构的技术特点。Sedona语言是一种通用的面向组件化的编程语言。Sedona虚拟机是一个小型解析器,具有良好的移植性,内嵌多种通信协议,可以运行在任何基于IP通信的网络上。最终实现各设备之间集中控制、分散管理的目标。     

EFFECT OF RARE EARTH ADDITIONS ON THE IMPACT FRACTURE OF Cr18Nil8Si2 STEEL

<正> Cr 18 Ni 18 Si 2钢经热处理后的低温冲击断口,其中加稀土的为穿晶断口,而未加稀土的为混合型断口。 试验用钢用高频感应炉冶炼,锭重20kg,锻成15×15mm方棒,再加工成冲击试样。其化学成分如下。稀土的加入是将一号混合稀土合金缚在钢棒上插入熔池。     

Adsorption characteristics of hexadecyl ammonium with different numbers of carbon chains in montmorillonite and the structure of the prepared composites

Journal of Porous Materials - The dynamics and thermodynamics of adsorption of hexadecyl ammonium with different numbers of carbon chains in montmorillonite (Mt) with different layer charge density...