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101.
102.
This study investigates quantitatively and qualitatively the sol-gel derived bioactive glass-ceramic system (BGS)—apatite-wollastonite (AW) type granules in the size range of 0.5–1 mm, as an effective graft material for bone augmentation and restoration. Scanning electron micrographs (SEM) of the sintered granules revealed the rough material surface with micropores in the range 10–30 μm. X-ray diffraction (XRD) pattern of the granules revealed the presence of crystalline phases of the hydroxyapatite and wollastonite, and the functional groups of the silicate and phosphates were identified by Fourier transform infrared spectroscopy (FT-IR). Thein vitro cell culture studies with L929 mouse fibroblast cell line showed very few cells adhered on the BGS disc after 24 h. This could be due to the highly reactive surface of the disc concomitant with the crystallization but not due to the cytotoxicity of the material, since the cellular viability (MTT assay) with the material was 80‰ Cytotoxicity and cytocompatibility studies proved that the material was non-toxic and biocompatible. After 12 weeks of implantation of the BGS granules in the tibia bone of New Zealand white rabbits, the granules were found to be well osteointegrated, as observed in the radiographs. Angiogram with barium sulphate and Indian ink after 12 weeks showed the presence of microcapillaries in the vicinity of the implant site implicating high vascularity. Gross observation of the implant site did not show any inflammation or necrosis. SEM of the implanted site after 24 weeks revealed good osteointegration of the material with the newly formed bone and host bone. New bone was also observed within the material, which was degrading. Histological evaluation of the bone healing with the BGS granules in the tibial defect at all time intervals was without inflammation or fibrous tissue encapsulation. After 2 weeks the new bone was observed as a trabeculae network around the granules, and by 6 weeks the defect was completely closed with immature woven bone. By 12 weeks mature woven bone was observed, and new immature woven bone was seen within the cracks of the granules. After 24 weeks the defect was completely healed with lamellar bone and the size of the granules decreased. Histomorphometrically the area percentage of new bone formed was 67.77% after 12 weeks and 63.37% after 24 weeks. Less bone formation after 24 weeks was due to an increased implant surface area contributed by the material degradation and active bone remodeling. The osteostimulative and osteoconductive potential of the BGS granules was established by tetracycline labelling of the mineralizing areas by 2 and 6 weeks. This sol-gel derived BGS granules proved to be bioactive and resorbable which in turn encouraged active bone formation.  相似文献   
103.
In this study, we describe the tracheal-relaxant and tocolytic activities of the methanol (ME) and aqueous (AQ) crude extracts of ginger (rhizome of Zingiber officinale) in an attempt to rationalize its traditional use in disorders of airways and uterine hyperactivity. Both of the ginger extracts dose-dependently relaxed K+ (80 mM) and carbachol (CCh, 1 μM)-induced contractions with more potency against K+, similar to that elicited by verapamil, a Ca2+ channel blocker. In isolated uterine preparations, the extracts suppressed the K+-induced contractions with respective EC50 values of 0.03 mg/ml (0.02–0.05, 95% CI) and 0.05 mg/ml (0.04–0.06). Activity-directed fractionation of AQ yielded an organic and an aqueous fraction with the activities concentrated in the former. Both the crude extracts were found safe in mice up to the oral dose of 5 g/kg when tested for acute toxicity for 24 h. The study shows that ginger possesses tracheal and uterine smooth muscle relaxant activity, possibility mediated via Ca2+ channel blockade, justifying its use in disorders such as asthma, cough as well as in dysmenorrhoea and uterine and menstrual spasms and congestion.  相似文献   
104.
An orthogonal basis for the hyperbolic hybrid polynomial space   总被引:1,自引:0,他引:1  
Motivated by the wide usage of the Tchebyshev basis and Legendre basis in the algebra polynomial space, we construct an orthogonal basis with the properties of the H-Bézier basis in the hyperbolic hybrid polynomial space, which is similar to the Legendre basis and holds remarkable properties. Moreover, we derive the transformation matrices that map the H-Bézier basis and the orthogonal basis forms into each other. An example for approximating the degree reduction of the H- Bézier curves is sketched to illustrate the utility of the orthogonal basis.  相似文献   
105.
An ideal topology type convergent theorem on scale effect algebras   总被引:1,自引:0,他引:1  
The famous Antosik-Mikusinski convergent theorem on the Abel topological groups has very extensive applications in measure theory, summation theory and other analysis fields. In this paper, we establish the theorem on a class of effect algebras equipped with the ideal topology. This paper shows also that the ideal topology of effect algebras is a useful topology in studying the quantum logic the- ory.  相似文献   
106.
为保证农村群众饮水安全和自来水工程正常运行,通过对全市农村自来水工程运行管理现状进行详细调查分析,针对管理体制、管理组织、水费计收、安全管理等方面存在的问题,提出了在农村自来水工程运行管理工作中应采取的对策及具体措施。即协会化管理,并按照"补偿成本、合理收益、公平负担、节约用水"的原则,实行有偿供水,计量收费;加强水质监测工作,确保水质符合国家饮用水标准,确保群众饮水安全。  相似文献   
107.
Application of Code Approach for Emergency Evacuation in a Rail Station   总被引:1,自引:0,他引:1  
Kai Kang 《Fire Technology》2007,43(4):331-346
This paper presents an emergency evacuation analysis during a mid-platform train fire in an underground rail station. A time-based evacuation scenario is developed taking into account the stairway inaccessibility due to smoke blockage. The calculation approach in NFPA 130 is then applied to a parametric study of this time-based scenario and its reliability is examined using a micro-simulation model. Both methods give consistent predictions of the exiting times. The results demonstrate that with the division of the station into two zones, the exiting time could not meet the code requirements, whereas it does meet the required exiting time without the division. Such division is due to smoke blockage and creates an uneven ratio of the occupant load to the available exiting capacity. This shows that appropriate consideration of the fire and smoke effects is important for station egress evaluation. Other issues such as the fire growth rate and the pre-evacuation time are also discussed.  相似文献   
108.
109.
In this study, distribution and history of residual stresses in plaque-like geometries are simulated based on linear thermoviscoelastic model, which helps to understand the mechanics and evolution of the residual stresses in the injection molding process. The numerical calculation of direction, combined with the specified boundary conditions. Results show that the stress variation across the thickness exhibits a high surface tensile value changing to a compressive peak value close to the surface, with the core region experiencing a parabolic tensile peak. Residual stress distribution throughout the thickness is almost same along the flowpath and the final residual stresses value near the gate is lower than the value near the end of flowpath.  相似文献   
110.
A method for the time suboptimal control of an industrial manipulator from an initial position and orientation to a final position and orientation as it moves along a specified path is proposed. Nonlinear system equations that describe the manipulator motion are linearized at each time step along the path. A method which gives the control inputs (joint angular velocities) for time suboptimal control of the manipulator is developed. In the formulation, joint angular velocity and acceleration limitations are also taken into consideration. A six degree of freedom elbow type manipulator is used in numerical examples to verify the method developed.  相似文献   
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