Continuous accountability for acceptable building performance

Complexities in building technology when not fully understood, have resulted in a less than favorable aggregate impact on the building's environment. A surprisingly high portion of U.S. non-industrial buildings do not provide satisfactory task environments. Developments in computer technology have infused new thought processes in the way we plan, design, build and operate our buildings. This paper proposes a social and technical use of Knowledge-based-systems (KBS) for continuous accountability to assure healthy buildings. Diagnostics, as an emerging discipline in building design and operation, is also discussed. A proposed framework for such accountability and the resulting ‘chain of custody’, that draws on the medical paradigm and associated diagnostic procedures is presented. It is suggested that KBS also be used for the development and interpretation of criteria for evaluating building performance from initial conception through design, construction and operation. Thus, KBS is expected to aid in the analysis of ‘virtual’ and ‘actual’ buildings that may be ‘sick’ or ‘healthy’. It is proposed that for a building to provide satisfactory performance over its life-time, the ‘life-cycle’ concept must be modified in terms of the roles, responsibilities, and configuration of the building team, and in terms of its costing procedures.     

X-ray and conformational analysis of arabinan

Fibers prepared from the enzymically debranched plant polysaccharide arabinan, containing (1-->5)-linked alpha-L-arabinofuranose residues, produce X-ray diffraction patterns containing concentric rings indicative of a high degree of structural organization. The measured unit cell dimensions and fiber density are consistent with a 2-fold helix passing through each unit cell. According to model-building techniques and energy calculations, a total of seven molecular structures (three with C2'-endo and four with C3'-endo sugars), all of pitch 8.74 A, and hence seven different crystal-packing arrangements are the most probable. While intrachain hydrogen bonds are only present in three cases, interhelix association is facilitated by hydrogen bonds in all allomorphs. Small energy differences between them suggest that easy conformational transitions may be made from one form to another. This polymorphism and the tendency to form microcrystals in the solid state might confer upon arabinan the observed fat mimetic properties.     

Electrochemical etching of highT c superconducting materials

HighT _c superconductor materials of yttrium barium copper oxide (YBCO) have been etched by a new electrochemical technique. In this technique, acids like hydrochloric, nitric and phosphoric have been used as an electrolyte and etching has been achieved with acid dilutions as high as 1:200 with water. It is observed that rapid and controlled etching is possible by this technique.     

Availability analysis of steam and power generation systems in the thermal power plant

The paper discusses the availability analysis of a steam generation system consisting of three subsystems A, B and D and a power generation system consisting of four subsystems E, F, G and H arranged in series, with three states viz., good, reduced and failed. Taking constant failure and repair rates for each working unit, the mathematical formulation is done using the Birth-Death process. Expressions for steady state availability and the MTBF (mean time between failure) are derived. The graphs are given, depicting the effect of failure and repair rates on the system availability. The results are supplied to the plant personnel, to plan the policies for failure free running of the systems for a long duration.     

Numerical and experimental analysis of large passivation opening for solder joint reliability improvement of micro SMD packages

In this paper, using a recently developed solder fatigue model for wafer level-chip scale package (WL-CSP), we investigated the improvement on solder joint reliability for a 8-bump micro SMD package by enlarging the passivation layer opening at the solder–die interface. The motivation to enlarge the passivation opening is to reduce the severity of the stress concentration caused by the original design, and also to increase the contact area between the solder bump and aluminum bump pad. It was confirmed in the thermal shock test that with the new design, package fatigue life improved by more than 70%. To numerically predict this improvement represents a unique challenge to the modeling. This is because in order to capture the slightest geometrical difference on the order of a few microns between the two designs, the multiple-layer solder-die interface needs to be modeled using extremely fine mesh, while the overall dimensions of the package and the test board are on the order of millimeters. To bridge this tremendous gap in geometry, a single finite element model that incorporates all necessary geometrical details is deemed computationally prohibitive and impractical. In this paper, we applied a global–local modeling scheme that was also suggested by others [1, 2 and 3]. The global model contains the complete package with much simplified solder–die interface whereas the local model includes only one solder joint, but with detailed solder–die interface. Unlike most global–local models proposed by others, we included time-independent plasticity and temperature-dependent materials in the global model. This greatly improved model correlation accuracy with only moderate increase in run time. Energy-based solder fatigue model was used to correlate the inelastic strain energy with the package fatigue life. In an earlier study [4], we have found that Darveaux’s equations tended to be conservative when applied to the micro SMD, and hence new correlations based on curve-fitting the test data were derived. In this paper, we used the newly derived equation and achieved less than 20% error in N₅₀ life for both designs, which is on par with Darveaux’s equations when used for BGAs. The analysis also revealed two factors that may account for the life improvement. First, a slight decrease in inelastic energy dissipation after enlarging the passivation opening. Second, the shift of the crack initiation location which leads to longer crack growth length for the new design. The second factor was also independently confirmed by the failure analysis.     

Data base design methodology for structural analysis and design optimization

A methodology to design data bases for finite element analysis and structural design optimization is described. The methodology considers three views of data organization-conceptual, internal, and external. Tabular and matrix forms of data are included. The relational data model is used in the data base design. Entity, relation, and attributes are considered to form a conceptual view of data. First, second, and third normal forms of data are suggested to design an internal model. Several aspects such as processing, iterative needs, multiple views of data, efficiency of storage and access time, and transitive data are considered in the methodology.     

Synthesis and evaluation of ciprofloxacin-loaded carboxymethyl tamarind kernel polysaccharide nanoparticles

Nanotechnology is currently employed as a tool to fight more efficiently against human pathogens. Nanoparticles can be prepared from a variety of materials such as protein, biodegradable polymers and synthetic polymers. Tamarindus indica Linn. or tamarind is one of the most important biodegradable polymer. In the present study, chemically modified polymer of tamarind ‘carboxymethyl tamarind kernel polysaccharide’ (CMTKP) is used for the synthesis of nanoparticulate formulation. Antibacterial activity of CMTKP was analysed which was then enhanced by incorporating a flouroquinolone antibiotic, ciprofloxacin to it. Ciprofloxacin-loaded CMTKP nanoparticles were synthesised via ionotropic gelation technique. Nanosuspension so formed was lyophilised by addition of a cryoprotectant. Nanoparticles obtained were characterised for its particle size, morphology and stability. Interaction studies were confirmed by Fourier transform infrared spectroscopy (FT-IR). Antibacterial activities of ciprofloxacin, CMTKP and ciprofloxacin-loaded CMTKP nanoparticles were tested against two Gram negative and positive bacteria. The antibacterial assay results revealed greatest zone of inhibition by ciprofloxacin-loaded CMTKP nanoparticles in Micrococcus luteus. Toxicity analysis of the prepared formulation was carried out on vero cell lines via resazurin assay which revealed its minimum toxicity.     

A Distortion-Sensitive Seam Carving Algorithm for Content-Aware Image Resizing

As displays become less expensive and are incorporated into more and more devices, there has been an increased focus on image resizing techniques to fill an image to an arbitrary screen size. Traditional methods such as cropping or resampling can introduce undesirable losses in information or distortion in perception. Recently, content-aware image retargeting methods have been proposed (Avidan and Shamir, ACM Trans Graphics 26(3), 2007; Guo et al., IEEE Trans Multimedia 11(5):856–867, 2009; Shamir and Avidan, Commun ACM 52(1), 2009; Simakov et al. 2008; Wolf et al. 2007), which produce exceptional results. In particular, seam carving, proposed by Avidan and Shamir, has gained attention as an effective solution. However, there are many cases where it can fail. In this paper we propose a distortion-sensitive seam carving algorithm for content-aware image resizing that improves edge preservation and decreases aliasing artifacts. In the proposed approach, we use local gradient information along with a thresholding technique to guide the seam selection process and provide a mechanism to halt seam carving when further processing would introduce unacceptable visual distortion in the resized image. Furthermore, anti-aliasing filter is used to reduce the aliasing artifacts caused by seam removal. Experiments have demonstrated superior performance over the current seam carving methods.     

Spatial distribution of manganese in enamel and coronal dentine of human primary teeth

Emerging evidence indicates that excessive exposure to manganese (Mn) during the prenatal period and early childhood may result in neurodevelopmental deficits. However, accurate exposure biomarkers are not well established, limiting our understanding of exposure-response relationships over these susceptible periods of development. Naturally shed deciduous teeth are potentially a useful biomarker of environmental exposure to Mn. However, the uptake and distribution of Mn in human teeth has not been studied in detail.Mn distribution was measured at high resolution (~ 20 μm) in eight human primary teeth using laser ablation-inductively coupled plasma-mass spectrometry. A bio-imaging methodology was applied to construct detailed elemental maps of three incisors, and bone meal (NIST SRM 1486) was used to validate the analyses.The distribution of Mn in enamel and coronal dentine showed a distinct and reproducible pattern. In enamel, the ⁵⁵Mn:⁴³Ca ratio was highest at the outer edge of enamel (range = 0.57 to 4.74) for approximately 20-40 μm but was substantially lower in deeper layers (range = 0.005 to 0.013). The highest levels of Mn were observed in dentine immediately adjacent the pulpal margin (⁵⁵Mn:⁴³Ca range = 2.27 to 6.95). Importantly, a clearly demarcated high Mn zone was observed in dentine at the incisal end of the teeth. Using confocal laser scanning microscopy to visualize the neonatal line, this region was identified as being in the prenatally formed dentine.The high-resolution map of the spatial distribution of Mn in human primary teeth highlighted specific reproducible patterns of Mn distribution in enamel and coronal dentine.     

Influenza virus hemagglutinin stimulates the protein kinase C activity of human polymorphonuclear leucocytes

Human polymorphonuclear leukocytes (PMNL) incubated with influenza virus, A/USSR/90/77 (H1N1) or its hemagglutinin produced a significant increase in their PKC activity when compared with untreated PMNL. The activated kinase translocated from cytosol to cellular membrane. The calcium-dependent enzyme activity was inhibited by a specific inhibitor suggesting that alpha and/or beta isoforms of PKC were involved.