Hydraulics of Stacked Drop Manholes

This paper presents the results of an experimental investigation on flows inside stacked drop manholes (SDM). An SDM consists of two identical rectangular or square manhole chambers stacked together at an elevation difference. SDMs for different conditions were assessed on their ability to dissipate the energy of the approaching flow and their suitability to perform adequately under different flow conditions. Flow regimes were classified based on the inflow conditions and geometry of the structure in the first chamber and downstream outflows in the second chamber. An analysis based on the integral momentum equation was developed to estimate pool depths and energy losses under critical flow conditions. A fully surcharged stage with inflow and outflow pipes running full was also tested and velocity profiles were measured at a horizontal center plane to the opening connecting both shafts. Additionally, air flow rates were measured to assess the air demand into a large-height SDM.     

Design, synthesis, and biological activity of urea derivatives as anaplastic lymphoma kinase inhibitors

In anaplastic large-cell lymphomas, chromosomal translocations involving the kinase domain of anaplastic lymphoma kinase (ALK), generally fused to the 5' part of the nucleophosmin gene, produce highly oncogenic ALK fusion proteins that deregulate cell cycle, apoptosis, and differentiation in these cells. Other fusion oncoproteins involving ALK, such as echinoderm microtubule-associated protein-like 4-ALK, were recently found in patients with non-small-cell lung, breast, and colorectal cancers. Recent research has focused on the development of inhibitors for targeted therapy of these ALK-positive tumors. Because kinase inhibitors that target the inactive conformation are thought to be more specific than ATP-targeted inhibitors, we investigated the possibility of using two known inhibitors, doramapimod and sorafenib, which target inactive kinases, to design new urea derivatives as ALK inhibitors. We generated a homology model of ALK in its inactive conformation complexed with doramapimod or sorafenib in its active site. The results elucidated why doramapimod is a weak inhibitor and why sorafenib does not inhibit ALK. Virtual screening of commercially available compounds using the homology model of ALK yielded candidate inhibitors, which were tested using biochemical assays. Herein we present the design, synthesis, biological activity, and structure-activity relationships of a novel series of urea compounds as potent ALK inhibitors. Some compounds showed inhibition of purified ALK in the high nanomolar range and selective antiproliferative activity on ALK-positive cells.     

Plane Turbulent Wall Jets on Rough Boundaries with Limited Tailwater

Combining the results of a laboratory study of plane turbulent wall jets on rough boundaries with shallow tailwater, with the results of an earlier work of Rajaratnam on wall jets on rough boundaries with deep tailwater, this paper attempts to describe the effects of boundary roughness and tailwater depth on the characteristics of plane turbulent wall jets on rough beds, which are important in the field of hydraulic engineering. The time-averaged axial velocity profiles at different sections in the wall jet were found to be similar, with some difference from the profile of the classical plane wall jet. The normalized boundary layer thickness δ/b, where b is the length scale of the velocity profile, was equal to 0.35 for wall jets on rough boundaries compared to 0.16 for the classic wall jet. Two stages were seen to exist in the decay of the maximum velocity um as well as in the growth of the length scale, with the first stage corresponding to that of deep tailwater and the second stage to shallow tailwater. In the first stage, the decay of the maximum velocity um at any section in terms of the velocity u0 at the slot, with the longitudinal distance x in terms of L which is the distance where um = 0.5U0, was described by one general function, for smooth as well as rough boundaries. The length scale L in terms of slot width decreases as the relative roughness of the boundary increases. The onset of the second stage was not affected significantly by the bed roughness. The growth rate of the length scale b of the wall jet increased from 0.076 for a smooth boundary to about 0.125 for a relative roughness ks/b0 in the range of 0.25 to 0.50, where ks is the equivalent sand roughness and b0 is the thickness of the jet at the slot.     

Structure of Flow Upstream of Vertical Angled Screens in Open Channels

This paper presents the results of a laboratory study of the structure of flow in a diversion structure with a vertical angled wedge-wire fish screen. This screen had a 10×25?mm mesh and was tested at three angles of 10.4, 17.5, and 26.8°, to the direction of the approaching flow, for two mean velocities of 0.5 and 0.8?m/s, with a depth of flow of about 0.75?m. In this water and fish diversion (channel or) structure, it was found that the depth of flow at any section is approximately constant with a drop at the screen on the side of the canal and decreased towards the bypass located at the downstream end. The distribution of the velocity component u in the direction of the approaching flow as well as the perpendicular component w and the resultant velocity V was uniform in the vertical direction. The depth averaged mean velocity for different verticals at any section in the diversion structure increased with the longitudinal distance x and was correlated with the relative width, bs/b (in the diversion structure) for all five experiments. Correlations have been found for the depth averaged transport velocity and the impinging velocity on the screen in terms of the approach velocity U. A general relation has also been developed for the attack angle of the flow on the screen. The downstream part of the screen carried more flow into the canal compared to the upstream part as a result of the uniform mesh size used in this study. The results of this hydraulic study should be useful, particularly for freshwater adult fish, in designing screens in irrigation canals and for micro-hydro sites that use diversion canals.     

Horizontal Injection of Gas–Liquid Mixtures in a Water Tank

Experiments were carried out to investigate the behavior of horizontal gas–liquid injection in a water tank. Measurements of bubble properties and mean liquid flow structure were obtained. The turbulence in the liquid phase appears to help generating bubbles with relatively uniform diameters of 1–4?mm. Both bubble properties and mean liquid flow structure depended on the gas volume fraction and the densimetric Froude number at the nozzle exit. It was found that the bubbles strongly affected the trajectory of the water jet, which behaved similarly to single-phase buoyant jets. However, at gas volume fractions smaller than about 0.15, the water jet completely separated from the bubble core. Bubble slip velocity was also found to be higher than the terminal velocity for isolated bubbles reported in the literature. Dimensionless correlations were proposed to describe bubble characteristics and the trajectory of the bubble plumes and water jets as a function of the gas volume fraction and the densimetric Froude number. Finally, applications of the results for aeration/mixing purposes are presented.     

2002 Summer Meeting Pictorial Review

This letter conducts load flow analysis of a five bus test system and repeats it for various sets of transmission line lengths, each with "lumped" and "distributed" models to compare the convergence, total transmission loss, and slack generation. From this comparison, we conclude that more transmission and generation capacity can be committed if a "distributed parameter" model replaces its "lumped" counterpart in such an analysis. The findings are expected to encourage the operators to take decisions through "distributed model"-based analyses so that more consumer demand can be satisfied as well as the utility's revenue substantially increased.     

Dissolved Oxygen Downstream of an Effluent Outfall in an Ice-Covered River: Natural and Artificial Aeration

In ice-covered rivers, dissolved oxygen (DO) might fall below critical levels for aquatic biota in the absence of surface aeration, combined with low winter flow conditions and reduced photosynthesis rates. Open-water zones, however, can be created downstream of a diffuser by warm effluent discharges, resulting in an increase in surface aeration. In this study, we modeled the behavior of the effluent plume and the resulting open-water lead development in the Athabasca River, Alberta, Canada downstream of a pulp mill diffuser. The DO was found to increase by 0.26?mg/L due to surface aeration of an open-water lead of 6.07?km. We also evaluated oxygen injection into the effluent pipeline to increase the DO in the river. At an injection rate of 3,500 and 5,000?lb/day of liquid oxygen, the DO was increased by 0.16 and 0.21?mg/L, which corresponded to an absorption efficiency of about 50%. The artificial aeration technique evaluated here appears to be an effective alternative to increase DO levels in ice-covered rivers. The results of this study are important in developing accurate DO models for ice-covered rivers and in evaluating oxygen injection systems.     

Generalized Study of Hydraulics of Culvert Fishways

This study presents a comprehensive analysis of the experimental observations, collected previously in an extended project on culvert fishways with offset baffle, slotted weir baffle, weir baffle, spoiler baffle, Alberta fishweir, and fishbaffle systems. It has been found that a general correlation exists between the dimensionless discharge Q? = Q/ and the relative depth of flow (y0/D) for each value of the relative baffle height (h/D). Furthermore, for relative baffle heights in the practical range of 0.1–0.15, longitudinal baffle spacing should be limited to a maximum of D. The velocity field in the centerplane of each of these culvert fishways was analyzed and was found to be similar with the similarity profiles having different shapes for different baffle systems. A general correlation was also found for the normalized velocity scale. Even though most of the baffle systems worked reasonably well in the range of parameters recommended, the weir and slotted weir baffle systems are simpler yet equally effective. The results presented in this paper will hopefully facilitate the design and building of successful culvert fishways.     

Air Injection in Water with Different Nozzles

Air injection systems have a wide range of environmental engineering applications. In this study, we conducted experiments on air injection in a relatively large water tank to investigate the effect of nozzle type, including single/multiple orifice nozzles and a porous airstone, on the characteristics of the bubbles and the induced flow structure. Measurements of bubble characteristics and flow field surrounding the bubble core were obtained using a double-tip optical probe and particle image velocimetry, respectively. The results revealed that bubble velocity did not change significantly with different nozzles, but bubble size decreased significantly while interfacial area, liquid entrainment rate, and kinetic energy of the mean and turbulent flow increased significantly by using the porous airstone instead of nozzles with large orifices. The results for a nozzle with multiple orifices of small diameter are comparable to those for the airstone, which suggests the suitability of its use for systems susceptible to clogging of the pores. Correlations using adequate length and velocity scales are also proposed to describe both bubble and liquid flow characteristics. Finally, applications of the results for different artificial aeration/mixing systems are presented.