Synthesis of Cherry Stalk Extract Based Organic@Inorganic Hybrid Nanoflowers as a Novel Fenton Reagent: Evaluation of Their Antioxidant,Catalytic, and Antimicrobial Activities

First time in this study, organic@inorganic hybrid copper nanoflowers (Cu NFs) were synthesized by using cherry stem extract as an organic component and Cu²⁺ ion as an inorganic component. For this purpose, cherry stalk extracts were obtained by using ethanol and water solvents. Cu NFs were synthesized in different amounts of extract (100–1000 µl) and under various pH (7.4–9) conditions. The morphologies of the synthesized Cu NFs were evaluated by field emission scanning electron microscope (FE-SEM). The functional groups in the cherry stem extract, which play an active role for the synthesis process, and the crystal structure of NFs were investigated by Fourier transform ?nfrared spectroscopy and X-ray diffraction techniques, respectively. It has been determined by the FE-SEM analysis that ethanol and water based cherry stem extracts are suitable for Cu NFs synthesis in a wide range of pH (7.4–9). This data is crucial for overcoming important limitations for NF synthesis, such as narrow-range medium pH. The catalytic, antioxidant, and antimicrobial activities of Cu NFs were evaluated. It was revealed that Cu NFs have catalytic, antioxidant, and antimicrobial activities. It is recommended that, cherry stem extract and different inorganic components are functional to synthesize numerous NFs and to evaluate the adequacy of use in biomedical fields.

     

The role of stably stratified fluid and anisotropy porous medium in modeling fluid flow through an asymmetrically heated/cooled vertical annulus

In this article, the natural convection of stratified fluid driven by the asymmetric heating and cooling of the surfaces of the concentric cylinders filled with an anisotropic porous matrix is investigated. The stratified fluid is confined between the outer surface of the inner cylinder and the inner surface of the outer cylinder while the onset transient natural convection is induced by the asymmetric heat heating/cooling of the inner surface of the outer cylinder while the outer surface of the inner cylinder is maintained at a constant temperature $T=1$. The present problem is governed by a pair of coupled second-order partial differential equations. To obtain the expressions for the temperature and velocity fields, the coupled mathematical equations describing the problem are systematically uncoupled such that their original orders remain unaltered. The research established that if the temperature of the outer surface of the inner cylinder equals the temperature of the inner surface of the outer cylinder, a symmetric flow occurs where two maxima velocities are observed close to the surfaces $Z=1$ and $\lambda$ of the annulus, respectively. Furthermore, for some constraints on certain values of some physical quantities in the flow solutions, the present work excellently compares with the research conducted by Jha and Oni.     

Measurement of fiber and matrix orientations in fiber reinforced composites

Short glass fiber reinforced polypropylene was employed in a study to determine the effect of molding and mold design variables on the distrubution of fibers and their orientations, and consequently, on the distributions of mechanical properties in the molded article. In this paper, a variety of experimental techniques were employed to evaluate the distributions of fibers and their orientations. Moreover, techniques were developed to evaluate the orientation and crystallization of the matrix. The results yield significant information regarding the development and control of both the microstructure and the properties of short fiber reinforced composites.     

Removal of leachate pollutants using flocculation method at simultaneous factors of optimum pH and Tacca leontopetaloides biopolymer flocculant (TBPF) dosage via face-centred central composite design

The effect of the interaction factor between pH and dosage is important in leachate wastewater treatment. This study aims to remove leachate pollutants such as turbidity, total suspended solid (TSS), chemical oxygen demand (COD) and colour using simultaneous factors of plant-based Tacca leontopetaloides biopolymer flocculant (TBPF) dosage and leachate pH. The flocculation process was carried out through jar test by applying the perikinetic theory and statical analysis (face-centred central composite design). The results found that the optimum leachate pH and TBPF dosage were pH 3 and 150 mg/L, respectively. The highest removal of leachate pollutants reached up to 69% with a second-order perikinetic model; R² = 0.9545 and k = 9 × 10⁻⁶ L/mg/min were obtained. Simultaneous interaction factors between leachate pH and TBPF dosage on turbidity and TSS removal were found significant and hence can be applied in the actual leachate wastewater treatment industry, particularly at the primary stage using the proposed model.     

Microbiological and physicochemical properties of farm bulk tank milk and antimicrobial resistance of its dominant bacteria

This study determined the antibiotic resistance of the dominant bacteria in the 85 farm BTMs according to the guidelines recommended by the epidemiological cutoff values in the EUCAST. In addition, some physicochemical and microbiological properties of farm BTMs were investigated. The milk samples were divided into two groups according to their SCC values. The milk samples with higher SCC than 400,000 cells mL⁻¹ were further examined bacteriologically, and the antibiotic resistance of isolates was determined. The average TAMB value was 6.34 log CFU/mL in farm BTM. It was found that high-SCC values did not affect other physicochemical properties of BTM samples, such as fat, protein and total solids, except for lactose content. Seventy-two strains were isolated from 45 bulk milk samples. The most prevalent bacteria were Enterococcus spp. (23.61%). The other isolates were Citrobacter spp. (12.5%), Staphylococcus spp. (12.51%), Serratia spp. (11.12%), Klebsiella spp. (9.72%), Bacillus spp. (9.72%), and Enterobacter spp. (8.33%). In antibiotic resistance analysis, 52.6% of Enterobacterales isolates showed cefoxitin resistance, and nine Enterobacterales isolates were determined as the presumptive ESBL producers. None of them was confirmed as ESBL producers. Moreover, MDR was detected in 83.3% of Enterobacter spp. isolates and all Bacillus spp. isolates. The over and inappropriate use of antibiotics in mastitis treatment may cause antibiotic-resistant microorganisms in milk. It was found that 52.7% of the isolated bacteria were MDR, which could pose a risk to public health and food safety, with the consumer's increasing interest in consuming raw milk.     

Synthesis and SAR Studies of Isoquinoline and Tetrahydroisoquinoline Derivatives as Melatonin Receptor Ligands

In our constant search for new successors of agomelatine, we report herein a new series of compounds resulting from bioisosteric modulation of the naphthalene ring. The isoquinoline and tetrahydroisoquinoline derivatives were synthesized and pharmacologically evaluated. This isosteric replacement of the naphthalene group of agomelatine has led to potent agonist and partial agonist compounds with nanomolar melatonergic binding affinities. Overall, the presence of a nitrogen atom was accompanied with a decrease in the binding affinity toward both MT₁ and MT₂ and the loss of 5HT_2C response, especially for tetrahydroisoquinoline in comparison with the parent compound. Interestingly, due to the presence of this nitrogen atom, a notable improvement in the pharmacokinetic properties was observed for all compounds.     

Time-dependent natural convection fluid flow of stably stratified fluid in an asymmetrically heated vertical channel filled with an anisotropic porous material

This paper presents a theoretical analysis of the combined effects of anisotropic porous material and thermal stratification on the transient natural convection fluid flow in an asymmetrically heated vertical parallel channel. The solutions of the governing equations for the temperature and velocity fields are obtained using Laplace transform technique, Riemann sum approximation, and the D'Alembert method. The choice of the D'Alembert method is to provide a simple decoupling procedure for the coupled governing equations while still retaining their original orders. The research established that owing to the layering effect induced by the thermal stratification $(S)$, the temperature and the velocity distributions of the fluid are found to be attenuated with an increase in thermal stratification. It is also observed that the inclusion of anisotropic parameters in the transport equations aids in regulating the fluid velocity, temperature, Nusselt number, skin friction, and mass flow rate. In addition, by neglecting the anisotropic parameter and taking into account the adiabatic stratification of the fluid, the numerical values for the mass flow rate of the present research favorably compared with the numerical results obtained by Singh et al.     

Time-dependent pressure-driven flow in a horizontal cylinder filled with a bidisperse porous material

Some properties of time-dependent that modify Brinkman equations for fluid flow in a cylindrical tube filled with Bidisperse Porous Material are discussed in this article. The fluid velocities through the fracture and porous phases of the Bidisperse Porous Medium (BDPM) resulting from the application of pressure gradient are described by two coupled second-order partial differential equations. Laplace transform technique, D'Alembert and Riemann-Sum Approximation Methods are used to obtain a semianalytical solution for the model. The choice of the D'Alembert is made to systematically decouple the coupled governing equations without altering their initial orders. The role of the coupling parameter: The coefficient of momentum transfer $(\eta )$ in the flow formation is considered. Accordingly, three cases are analyzed: (a) weak coupling $(\eta =0)$ which described the fluid flow in the absence of the coupling parameter, (b) the strong coupling resulting from a large value of the coupling parameter $(\eta \to \infty )$, and (c) fluid momentum for any arbitrary value of $\eta$. It is observed that fluid stability is attained when ${\mathit{Da}}_f$ and ${\mathit{Da}}_p$ are decreased; a finding that agrees with the findings of Nield and Kuznetsov and Magyari. Also, the maximum velocity in the fracture phase of the BDPM is attained when the coefficient of momentum transfer is neglected $(\eta =0)$ while an opposing flow formation is demonstrated in the fracture and porous phases of BDPM as $\eta$ is increased.     

Estimation of the volume resistivity of electrically conductive composites

The modeling of the electrical conductivity of polymer composites reinforced with conductive fibers is investigated. Existing models generally can be divided into percolation theories and non-percolation theories. The basis of the percolation theory is the fact that the conductivity of the composite increases dramatically at a certain fiber concentration called the percolation threshold. This theory can be used to model the behavior of the composite or to predict the percolation threshold itself. Non-percolation theories include terms, which account for microstructural data such as fiber orientation, length, and packing arrangement. A comparison of experimental data with predictions from the various models reveals that only the percolation theory is able to accurately model the conductive behavior of an actual composite. Two alternative new models, which predict the volume resistivity of a composite using microstructural data, are evaluated. The first model relates resistivity to the concentration and orientation of the fibers, while assuming perfect fiber-fiber contact. The relationship between resistivity and fiber concentration predicted by the model is in qualitative agreement with actual data, and predictions of the anisotropy in volume resistivity compare well with experimental results. The second model accounts for the effect of fiber-fiber contact and fiber length on composite resistivity. Predictions are in excellent agreement with experimental data for polypropylene composites reinforced with nickel-coated graphite fibers.