排序方式: 共有41条查询结果,搜索用时 15 毫秒
31.
Hanne Solvang Felberg Rasa Slizyté Revilija Mozuraityte Stine Wiborg Dahle Ragnar L. Olsen Iciar Martinez 《Food chemistry》2009
The aim of the work was to examine the effect of allowing herring (Clupea harengus) to empty the stomachs prior to being taken on board the fishing vessels, on the proteolytic activities in extracts of ventral muscle and of intestinal content. The proteolytic activities were examined by gelatin zymography and by incubating the extracts with isolated myosin heavy chain (MHC) protein. Extracts from herring with full stomachs showed strong gelatinolytic and MHC degrading activities particularly in extracts from intestinal contents. Extracts from fish that had been allowed to empty their digestive system for 19 h had reduced activities, which was most noticeable in the ventral muscle extracts. The activities from the ventral muscle did not originate endogenously post-mortem, as shown by the fact that ice storage for 24 h of isolated ventral muscle did not display the activities, while ventral muscle extract from ice-stored whole fish for 24 h did. 相似文献
32.
Rasa Juciute 《AI & Society》2009,23(1):131-137
As modern information and communication technologies (ICT) now offer new possibilities for improving almost every aspect of
health care, their implementation is a very relevant and fast accelerating process around Europe and internationally. The
processes themselves vary greatly from scattered single initiatives of various IT solutions to large national programmes.
Often treated as purely technical in nature, ICT implementation in health care should gravitate towards the “softer/complex”
i.e. people-related issues end of the change. The approach taken by the Informing Healthcare programme in Wales broadens understanding on the value that engagement of stakeholders can bring to the process.
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Rasa JuciuteEmail: |
33.
In this work, we investigated how DC and pulsed DC Ar gas plasma treatment changes surface topography and chemical composition of silicon and expanded Polytetrafluoroethylene (ePTFE) substrates and how different surface pretreatment techniques can affect the formation and hydrogenation of Mg and Mg–Ti films. It is observed that pre-treating Si and ePTFE substrates with different plasma modes results in significant changes of microstructures of as-deposited Mg and Mg–Ti films. After the hydrogenation of Mg films at 20 bar H2 pressure and 180 °C temperature the formation of crystalline MgH2 phase is observed only for the films deposited on plasma non-treated Si substrates which had the films with smallest dimensions of its columnar structure. It is known that, usually, Ti additives has positive effect on hydrogenation properties of Mg, but in this study independently of the used substrate pre-treatment technique after the hydrogenation of Mg–Ti films their XRD analysis showed no peaks of the crystalline hydride phase. However, depending on the surface properties of the substrate after hydrogenation Mg–Ti films also have several disparities which are discussed and attributed to the potentially related substrate features. 相似文献
34.
Rasa Ghaffarian Edgar Pérez‐Herrero Hyuntaek Oh Srinivasa R. Raghavan Silvia Muro 《Advanced functional materials》2016,26(20):3382-3393
When administered intravenously, active targeting of drug nanocarriers (NCs) improves biodistribution and endocytosis. Targeting may also improve NC oral delivery to treat gastrointestinal (GI) pathologies or for systemic absorption. However, GI instability of targeting moieties compromises this strategy. This study explores whether encapsulation of antibody‐coated NCs in microcapsules would protect against gastric degradation, providing NC release and targeting in intestinal conditions. Nanoparticles coated with antibodies against intercellular adhesion molecule‐1 (anti‐ICAM) or nonspecific immunoglobulin G (IgG) are encapsulated in chitosan (shell) ‐ alginate (core) microcapsules. Encapsulation efficiency is >95% and NC relase from microcapsules in storage is <10%. There is minimal NC release at gastric pH (<10%) and burst release at intestinal pH (75%–85%). Encapsulated NCs afford increased protection against degradation (threefold to fourfold) and increased cell targeting (8–20‐fold) after release versus the nonencapsulated NCs. Mouse oral gavage shows that microencapsulation provides 38%–65% greater protection of anti‐ICAM NCs in the GI tract, 40% lower gastric retention, and fourfold to ninefold enhanced intestinal biodistribution versus nonencapsulated NCs. Therefore, microencapsulation of antibody‐targeted NCs may enable active targeting strategies to be effective in the context of oral drug delivery. 相似文献
35.
Mohammad Salehian Rasa Soleimani 《Energy Sources, Part A: Recovery, Utilization, and Environmental Effects》2018,40(15):1814-1825
The Integrated Capacitance Resistive Model (ICRM), a linearized form of Capacitance Resistive Models (CRM), has been commonly used to match liquid production history and estimate interwell connectivity (IWC) in waterflooded reservoirs. Although this model fits cumulative production data accurately, it usually fails to estimate correct values of total production, where backward subtraction of cumulative production delivers highly overestimated or underestimated total production rates. To address this issue, a modified optimization approach is presented to minimize the error between both cumulative and total production data through two consecutive constrained objective functions. This paper validates the modified ICRM in homogeneous synthetic examples with vertical wells to show how the new approach can successfully characterize the waterflooded reservoirs. The model was also tested in damaged formations to detect its impact on the communication between wells. Finally, a correlation is proposed to explain the mathematical and physical relationship between formation damage (skin factor) and IWC of the damaged well.
Abbreviations BHP: bottom-hole pressure; CMG: computer modeling group Ltd.; COF: Consecutive objective function; CRM: capacitance-resistive model or capacitance-resistance model; CWI: cumulative water injection; ICRM: integrated capacitance-resistance model; IMEX: Implicit-explicit black oil simulator 相似文献
36.
Polyaniline fibre microelectrodes prepared from a doped solution of polyaniline protonated with 2-acrylamido-2-methyl-1-propanesulphonic acid in dichloracetic acid were characterized electrochemically for the first time. Low scan rate cyclic voltammetry was used for characterisation in different acid electrolyte solutions, hydrochloric, nitric, perchloric, sulphuric and phosphoric, at low pH values with varying positive potential limits. Electrochemical impedance spectroscopy was also utilised. The electrochemical behaviour of polyaniline (PANI) fibres was found to be similar to that of PANI films obtained by electropolymerisation on metallic electrode substrates. The conduction potential window was found to be from +0.20 to +0.60 V versus SCE, with small variations in the different acid solutions as well as with pH. The standard electrochemical redox couple hexacyanoferrate(III), was found to behave quasi-reversibly in the conduction potential region and rate constants were evaluated. 相似文献
37.
Photonic Network Communications - The upcoming 5G cellular wireless network brings new challenges and problematic issues in providing services with different quality of service (QoS) requirements... 相似文献
38.
Algirdas
alimas Raimonda Kubilit Kristina
ukauskait Rasa Sabaliauskait Mantas Trakymas Simona Letautien Edita Mieikyt Kaubrien Jurgita Uinskien Albertas Ulys Sonata Jarmalait 《International journal of molecular sciences》2022,23(24)
Active surveillance (AS) is the best strategy for small renal masses (SRMs) management; however, reliable methods for early detection and disease aggressiveness prediction are urgently needed. The aim of the present study was to validate DNA methylation biomarkers for non-invasive SRM detection and prognosis. The levels of methylated genes TFAP2B, TAC1, PCDH8, ZNF677, FLRT2, and FBN2 were evaluated in 165 serial urine samples prospectively collected from 39 patients diagnosed with SRM, specifically renal cell carcinoma (RCC), before and during the AS via quantitative methylation-specific polymerase chain reaction. Voided urine samples from 92 asymptomatic volunteers were used as the control. Significantly higher methylated TFAP2B, TAC1, PCDH8, ZNF677, and FLRT2 levels and/or frequencies were detected in SRM patients’ urine samples as compared to the control. The highest diagnostic power (AUC = 0.74) was observed for the four biomarkers panel with 92% sensitivity and 52% specificity. Methylated PCDH8 level positively correlated with SRM size at diagnosis, while TFAP2B had the opposite effect and was related to SRM progression. To sum up, SRMs contribute significantly to the amount of methylated DNA detectable in urine, which might be used for very early RCC detection. Moreover, PCDH8 and TFAP2B methylation have the potential to be prognostic biomarkers for SRMs. 相似文献
39.
Targeted Oral Drug Delivery: Chitosan–Alginate Microcapsules Provide Gastric Protection and Intestinal Release of ICAM‐1‐Targeting Nanocarriers,Enabling GI Targeting In Vivo (Adv. Funct. Mater. 20/2016)
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40.
A Baykal D Onat K Rasa N Renda I Sayek 《Canadian Metallurgical Quarterly》1997,21(6):579-82; discussion 582-3
The purpose of this study was to investigate the effects of polyglycolic acid (PGA), an absorbable (ABS) mesh, and polypropylene (PP), a nonabsorbable (NA) mesh, on intestinal adhesion formation. Altogether 72 mice were divided into a control group of 24, an ABS mesh group of 23, and an NA mesh group of 25. All three groups were divided into two subgroups for evaluation of adhesion severity at postoperative (po) days 5 and 90. Adhesion severity was measured with adhesion grading and tissue hydroxyproline (OHP) levels. Adhesion degree was minimal (1) in all subjects on day 5. Also there was no difference in tissue OHP levels between three groups on day 5 (p > 0.05). Adhesion degree and tissue OHP levels as determinants of adhesion severity were higher in the PGA mesh group than the control group and the PP mesh group on day 90 (p < 0.001). There was no difference between the control group and the PP mesh groups (p > 0.05). Adhesion degree was higher on day 90 than on day 5 in the control group and the PGA mesh group (p < 0.05), whereas tissue OHP level was higher on day 90 than on day 5 in all three groups (p < 0.001). Also there was linear correlation between adhesion degree and tissue OHP levels (r = 0.86, p < 0.001). The study demonstrates that ABS PGA mesh has higher potential for adhesion formation than the NA PP mesh, probably related to the increased foreign body and inflammatory reactions during the absorption process of the mesh. 相似文献