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81.
Sung KB Liang C Descour M Collier T Follen M Richards-Kortum R 《IEEE transactions on bio-medical engineering》2002,49(10):1168-1172
We have built a fiber-optic confocal reflectance microscope capable of imaging human tissues in near real time. Miniaturization of the objective lens and the mechanical components for positioning and axially scanning the objective enables the device to be used in inner organs of the human body. The lateral resolution is 2 micrometers and axial resolution is 10 micrometers. Confocal images of fixed tissue biopsies and the human lip in vivo have been obtained at 15 frames/s without any fluorescent stains. Both cell morphology and tissue architecture can be appreciated from images obtained with this microscope. 相似文献
82.
Gold James M.; Fuller Rebecca L.; Robinson Benjamin M.; McMahon Robert P.; Braun Elsie L.; Luck Steven J. 《Canadian Metallurgical Quarterly》2006,115(4):658
This study reports evidence that individuals with schizophrenia (SC) demonstrate intact attentional selection for visual working memory (WM) storage. A group of 62 participants with SC and 55 control participants without SC were studied in a series of 5 experiments that examined the ability to use top-down and bottom-up cues to guide WM encoding, as well as the ability to spontaneously select a subset of representations for storage. Participants with SC exhibited a consistent and robust ability to use selective attention in the control of WM in all 5 experiments, demonstrating a remarkable island of preserved functioning given the broad spectrum of impairments of attention and WM that have been widely reported in those with SC. These findings indicate that attention is not globally impaired in SC and make it possible to delineate more precisely the nature of the specific impairment of attention in this disorder. (PsycINFO Database Record (c) 2010 APA, all rights reserved) 相似文献
83.
Tucker Joan S.; Ellickson Phyllis L.; Collins Rebecca L.; Klein David J. 《Canadian Metallurgical Quarterly》2006,20(4):363
This longitudinal study compared Grade 8 solitary cigarette smokers (n = 541), drinkers (n = 577), and marijuana users (n = 148) with adolescents who restricted their use of these substances to social settings (ns = 562, 1,426, and 388, respectively) on adolescent functioning and young adult outcomes. In Grade 8, solitary users held more positive beliefs about the consequences of substance use, earned poorer grades, engaged in more deviant behavior, and devoted less time to school and more time to social activities. By age 23, these solitary users had lower educational attainment, poorer self-rated health, and greater substance use problems. Results indicate the importance of better understanding and addressing the needs of this understudied group of high-risk youth. (PsycINFO Database Record (c) 2010 APA, all rights reserved) 相似文献
84.
Kathryn I Pollak Cheryl A Oncken Isaac M Lipkus Bercedis L Peterson Geeta K Swamy Pamela K Pletsch Pauline Lyna Rebecca J Namenek Brouwer Laura J Fish Evan R Myers 《Nicotine & tobacco research》2006,8(4):547-554
Improvements in smoking cessation interventions for pregnant smokers are needed. One major step is to examine the potential effectiveness of nicotine replacement therapy (NRT). The potential benefits of providing pregnant women with NRT to help them quit smoking are still unknown; early interventions to test the effectiveness and efficacy are vital to advancing the field. This paper describes recruitment efforts for a multiclinic trial to test the effectiveness of NRT use in addition to behavioral therapy in promoting cessation during pregnancy. The biggest challenge is recruiting sufficient numbers of pregnant women. This paper discusses specific obstacles for recruitment and solutions. Knowing the potential pitfalls to recruiting pregnant women into these trials can lead to better studies and thus improved outcomes. 相似文献
85.
Carmona Gilberto N.; Schindler Charles W.; Shoaib Mohammed; Jufer Rebecca; Cone Edward J.; Goldberg Steven R.; Greig Nigel H.; Yu Qian-Sheng; Gorelick David A. 《Canadian Metallurgical Quarterly》1998,6(3):274
A primary enzyme for the metabolism of cocaine is butyrylcholinesterase (BChE). To determine whether the systemic administration of BChE can increase the metabolism of cocaine sufficiently to alter a behavioral effect, rats were tested in a locomotor activity chamber after receiving 17 mg of cocaine per kg intraperitoneally. In rats pretreated intravenously with 5,000 IU of horse serum-derived BChE, the locomotor activity effect was significantly attenuated. BChE pretreatment increased plasma BChE levels approximately 400-fold. When added to rat plasma, this amount of BChE reduced the cocaine half-life from over 5 hr to less than 5 min. BChE altered the cocaine metabolic pattern such that the relatively nontoxic metabolite ecgonine methyl ester was produced, rather than benzoylecgonine. These results suggest that systemic administration of BChE can increase the metabolism of cocaine sufficiently to alter a behavioral effect of cocaine and thus should be investigated as a potential treatment for cocaine abuse. (PsycINFO Database Record (c) 2010 APA, all rights reserved) 相似文献
86.
The stability of halo errors when the ratees, the specific behavioral episodes observed, or both varied was studied. In a laboratory study, halo errors were highly unstable when either the ratees or the ratee behaviors varied (average stability coefficients were .20 and .18 when ratee behavior or both ratees and their behavior varied, respectively), but halo errors were moderately stable when the ratees and the specific performance segments viewed were kept constant. In a field study using actual teacher ratings in which the ratee, the ratee's role, or the semester in which ratings were obtained was varied, very low stability coefficients were again found. The results suggest that halo error is not a stable characteristic of the rater or the ratees but rather is partly a characteristic of the unique rating situation. Practical and theoretical implications are discussed. (PsycINFO Database Record (c) 2010 APA, all rights reserved) 相似文献
87.
Renner R 《Environmental science & technology》1996,30(2):74A
Government. 相似文献
88.
89.
Nyquist RM Ataka K Heberle J 《Chembiochem : a European journal of chemical biology》2004,5(4):431-436
The catalytic action of membrane proteins is vital to many cellular processes. Yet the molecular mechanisms remain poorly understood. We describe here the technique of evanescent infrared difference spectroscopy as a tool to decipher the structural changes associated with the enzymatic action of membrane proteins. Functional changes as minute as the protonation state of individual amino acid side chains can be observed and linked to interactions with a ligand, agonist, effector, or redox partner. 相似文献
90.