Strengthening the Junction Between EPDM and Aluminium Substrate via Plasma Polymerisation

High interfacial strengths of elastomer to metal joints imply the formation of covalent bonds at the interface. It is proposed to deposit a plasma polymer coating containing double bonds on an aluminium substrate for the formation of crosslinks between the elastomer and the coating during peroxide crosslinking of the elastomer. Ethylene-co-propylene-co-diene terpolymer (EPDM) is considered here. Maleic anhydride is polymerised and reacted with allylamine to lead to an amide functionalised plasma polymer which is heated to produce imide functional groups. Plasma polymer coated aluminium/EPDM joints were evaluated by a peel test and the locus of failure was identified by several techniques: SEM, infrared spectroscopy, wettability, and XPS.     

Gene sorting in differential evolution with cross-generation mutation

Gene sorting is proposed in this paper as a method of ordering trial vector’s component in dif- ferential evolution (DE). This method tends to significantly increase the convergence speed of DE with just a little modification on the original algorithm. In the meantime, a new concept of cross-generation mutation is introduced in order to perform the evolution process serially rather than parallelly. When combined with gene sorting, this method will further increase the convergence speed. A benchmar...     

Management of mobile ad hoc networks: information model and probe‐based architecture

The increasing need for mobility in networks and computing leads to the deployment of wireless networks without fixed infrastructure, called ad hoc networks. These networks raise new challenges towards monitoring and managing them to provide optimal performance. We propose in this paper a management framework to assess the operational state and the behaviour of mobile ad hoc networks. After presenting the management requirements, we define an information model to manage these networks. Simulations provide an overview of how this model can be used. Finally, we describe a probe‐based architecture with an implementation prototype, to use and populate the information model in a realistic environment. Copyright © 2005 John Wiley & Sons, Ltd.     

A new tool for processing atmospheric emission inventories: Technical aspects and application to the ESCOMPTE study area

Emission databases need to be processed for several purposes, e.g., policy and scientific, and so require flexible and fast handling. As a result, the creation and use of convenient interactive tools allowing easy and fast processing are of high importance. In this paper, a new software devoted to emission inventories processing is presented and applied to the actualization of the ESCOMPTE inventory. The ESCOMPTE inventory is a yearly (1999) high-resolution (1 km²) emission inventory created for use in chemical transport models to study ozone pollution. This tool includes several functions allowing the update of emission inventories at different temporal and spatial resolutions based on the reference ESCOMPTE inventory. The actualized yearly and hourly inventories are found consistent with the hypothesis involved in emission inventory creation. Due to its flexible architecture, several other applications related to air quality analysis can be performed such as the creation of emission scenarios allowing the evaluation of abatement strategies and regulation effects on anthropogenic emissions. Also, the architecture of the software allows an easy application to other emission inventories provided that they have similar or adaptable structure compared to the ESCOMPTE one.     

Skeletal Optimization of Cytotoxic Lipidic Dialkynylcarbinols

In line with a recent study of the pharmacological potential of bioinspired synthetic acetylenic lipids, after identification of the terminal dialkynylcarbinol (DAC) and butadiynyl alkynylcarbinol (BAC) moieties as functional antitumor pharmacophoric units, this work specifically addresses the issue of carbon backbone length. A systematic variation of the aliphatic chain length was thus carried out in both the DAC and BAC series. The critical impact of the length of the lipidic skeleton was first confirmed in the racemic series, with the highest cytotoxic activity observed for C₁₇ to C₁₈ backbones. Enantiomerically enriched samples were prepared by asymmetric synthesis of the optimal C₁₈ DAC and C₁₇ BAC derivatives. Samples with upgraded enantiomeric purity were alternatively produced by enzymatic kinetic resolution. Eutomers possessing the S configuration displayed cytotoxicity IC₅₀ values as low as 15 nm against HCT116 cancer cells, the highest level of activity reached to date in this series.     

On the Efficiency of a VR Hand Gesture-Based Interface for 3D Object Manipulations in Conceptual Design

In the early stages of 3D design, sketches are used to quickly conceptualize ideas and gain insight into problems and possible solutions. Computer-aided design tools are widely used for 3D modeling and design, but their required precision and 2D mouse and screen-based interface inhibit the flow of ideas. A study was conducted to explore the efficiency of hand tracking and virtual reality (VR) for 3D object manipulations in conceptual design. Based on existing research on conceptual design and hand gestures, an intuitive hand-based interaction model is proposed. An experiment on basic 3D manipulation shows that participants using a simple VR and hand-tracking interface prototype have similar performance to those using a traditional mouse and screen interface. For the improvement of gestural conceptual design interfaces, the relevant issues are identified.     

A Microfluidic Platform to Monitor Real-Time Effects of Extracellular Vesicle Exchange between Co-Cultured Cells across Selectively Permeable Barriers

Exosomes and other extracellular vesicles (EVs) play a significant yet poorly understood role in cell–cell communication during homeostasis and various pathological conditions. Conventional in vitro and in vivo approaches for studying exosome/EV function depend on time-consuming and expensive vesicle purification methods to obtain sufficient vesicle populations. Moreover, the existence of various EV subtypes with distinct functional characteristics and submicron size makes their analysis challenging. To help address these challenges, we present here a unique chip-based approach for real-time monitoring of cellular EV exchange between physically separated cell populations. The extracellular matrix (ECM)-mimicking Matrigel is used to physically separate cell populations confined within microchannels, and mimics tissue environments to enable direct study of exosome/EV function. The submicron effective pore size of the Matrigel allows for the selective diffusion of only exosomes and other smaller EVs, in addition to soluble factors, between co-cultured cell populations. Furthermore, the use of PEGDA hydrogel with a very small pore size of 1.2 nm in lieu of Matrigel allows us to block EV migration and, therefore, differentiate EV effects from effects that may be mediated by soluble factors. This versatile platform bridges purely in vitro and in vivo assays by enabling studies of EV-mediated cellular crosstalk under physiologically relevant conditions, enabling future exosome/EV investigations across multiple disciplines through real-time monitoring of vesicle exchange.     

Synthesis and characterization of novel benzhydrol-containing poly(amide-imide)s

A series of novel benzhydrol-containing poly(amide-imide)s (PAIs) have been prepared from a new diimide-dicarboxylic acid, N,N′-bis(4-hydroxycarbonyl)-benzhydrol-3,3′,4,4′-tetracarboxydiimide (BHTDA-DIA), with various diamines by direct polycondensation using triphenyl phosphite and pyridine as condensing agents. The polymers obtained had inherent viscosities of 0.35–0.96 dl g⁻¹. All these PAIs, except polymer PAI-2, were soluble in N-methyl-2-pyrrolidinone and N,N-dimethylacetamide containing LiCl (1 wt%). Tough and flexible PAI films could be obtained by casting PAIs from their DMAc or NMP solutions, except for polymer PAI-2. The polymer films had a tensile strength of 93–111 MPa, an elongation at break range of 4–6%, and an initial modulus range of 2.7–3.8 GPa. The glass transition temperatures of most polymers were found to be above 255 °C. These polymers were fairly stable up to a temperature around or above 400 °C, and lost 10% weight in the range 426–507 °C in nitrogen and 423–515 °C in air. © 1999 Society of Chemical Industry     

Handling effective communication to support awareness in rescue operations

Efficient rescue operations require a high level of situation awareness amongst decision‐makers and first responders for the purpose of achieving operations successfully and reducing losses. Moreover, a common operational picture between involved actors is required in order to support decision‐making. Therefore, different organisations and agencies have to collaborate, cooperate, and coordinate their actions with each other. Hence, effective interactions and communications between participants are vital to fulfil these essential needs. However, emergency actors still lack backing to exchange information effectively and ensure a common operational picture in order to reach shared situational awareness. For this reason, we aim to develop and implement Rescue MODES, a communication system oriented to support situation awareness amongst French emergency actors in rescue operations. In this paper, we examine and analyse actors’ activities and interactions, so that the system will be based on the real needs of actors. We start by studying and modelling the communications, interactions, and information flow. This modelling is based on an application ontology. Then, we define requirements for good communication in these operations and present some existing systems in France and how each system responds to these requirements.     

Controlled Inline Fluid Separation Based on Smart Process Tomography Sensors

Today's mechanical fluid separators in industry are mostly operated without any control to maintain efficient separation for varying inlet conditions. Controlling inline fluid separators, on the other hand, is challenging since the process is very fast and measurements in the multiphase stream are difficult as conventional sensors typically fail here. With recent improvement of process tomography sensors and increased processing power of smart computers, such sensors can now be potentially used in inline fluid separation. Concepts for tomography-controlled inline fluid separation were developed, comprising electrical tomography and wire-mesh sensors, fast and massive data processing and appropriate process control strategy. Solutions and ideas presented in this paper base on process models derived from theoretical investigation, numerical simulations and analysis of experimental data.