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41.
5,8,11-Eicosatrienoic acid (20∶3ω9), a fatty acid increased in the platelet phospholipids of man and animals fed saturated fats, was either added to human platelets simultaneously with the aggregating agents, or incorporated into the platelet phospholipids by preincubation. 20∶3ω9 markedly increased the response of platelets to all aggregating agents tested when added simultaneously with the agent, but solely to thrombin and ionophore, after incorporation into the platelet phospholipids. The potentiating effects of 20∶3ω9 on thrombin aggregation do not appear to be related to prostaglandin formation, but rather to the production of a monohydroxy derivative through the lipoxygenase pathway. 相似文献
42.
Diffraction by the subreflector of a revolution dual reflector antenna is studied as contribution to the side-lobe radiation of the antenna; a better knowledge of this sidelobe radiation is necessary in order to satisfy more and more difficult specifications. Calculation of the subreflector diffracted field is made with geometrical theory of diffraction and more precisely with the uniform asymptotic theory. The antenna is made of two revolution surfaces generated by two meridian curves which are not necessarily the set hyperbola-parabola of the classical Cassegrainian antenna. Computation results are compared to measurements made on the subreflector of an existing antenna. The agreement is satisfying particularly in the angular zone corresponding to the primary feed spill-over. 相似文献
43.
44.
Ronan Le Hyaric Hassen Benbelkacem Julien Bollon Rémy Bayard Renaud Escudié Pierre Buffière 《Journal of chemical technology and biotechnology (Oxford, Oxfordshire : 1986)》2012,87(7):1032-1035
The objective of this study was to evaluate the influence of moisture content on the specific methanogenic activity (SMA) of a fresh dry mesophilic digestate from a municipal solid waste digester plant. For this purpose, SMA tests were performed under mesophilic conditions in 500 mL glass bottles of volume used as batch reactors, during a period of 20–25 days. Cellulose, propionate and acetate were used as substrates (5 gCOD kg?1 digestate) at four different moisture contents, ranging from 65 to 82%. The moisture content strongly influenced the specific methanogenic activity. The highest SMA values were observed at a moisture content of 82% (11.1, 7.8 and 6.0 mgCOD gVS?1 d?1 for cellulose, propionate and acetate spikes, respectively). SMA and moisture content were found to be linearly linked. Dry digestion at low water content is thus detrimental to the biological activity, probably due to physical limitations. Copyright © 2011 Society of Chemical Industry 相似文献
45.
Sergiy Patskovsky Renaud Jacquemart Michel Meunier Gregory De Crescenzo Andrei V. Kabashin 《Sensors and actuators. B, Chemical》2008,133(2):628-631
We here describe a scheme of spatially modulated surface plasmon resonance (SPR) polarimetry that enables to combine ultra-high phase sensitivity with good signal-to-noise background. The proposed approach uses spatial modulation of s-polarized component by birefringent elements and the extraction of phase-polarization information by Fourier-transform methods. This scheme was tested for monitoring the interactions between an antibody and its biological partner. Our experimental data, collected by amplitude-sensitive and phase-sensitive polarimetry demonstrate that the latter scheme provides at least one order of magnitude improvement in terms of detection limit. 相似文献
46.
One Question,Multiple Answers: Biochemical and Biophysical Screening Methods Retrieve Deviating Fragment Hit Lists
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Dr. Johannes Schiebel Nedyalka Radeva Dr. Helene Köster Dr. Alexander Metz Timo Krotzky Dr. Maren Kuhnert Prof. Wibke E. Diederich Prof. Andreas Heine Dr. Lars Neumann Dr. Cedric Atmanene Dominique Roecklin Dr. Valérie Vivat‐Hannah Dr. Jean‐Paul Renaud Dr. Robert Meinecke Dr. Nina Schlinck Dr. Astrid Sitte Franziska Popp Dr. Markus Zeeb Prof. Gerhard Klebe 《ChemMedChem》2015,10(9):1511-1521
Fragment‐based lead discovery is gaining momentum in drug development. Typically, a hierarchical cascade of several screening techniques is consulted to identify fragment hits which are then analyzed by crystallography. Because crystal structures with bound fragments are essential for the subsequent hit‐to‐lead‐to‐drug optimization, the screening process should distinguish reliably between binders and non‐binders. We therefore investigated whether different screening methods would reveal similar collections of putative binders. First we used a biochemical assay to identify fragments that bind to endothiapepsin, a surrogate for disease‐relevant aspartic proteases. In a comprehensive screening approach, we then evaluated our 361‐entry library by using a reporter‐displacement assay, saturation‐transfer difference NMR, native mass spectrometry, thermophoresis, and a thermal shift assay. While the combined results of these screening methods retrieve 10 of the 11 crystal structures originally predicted by the biochemical assay, the mutual overlap of individual hit lists is surprisingly low, highlighting that each technique operates on different biophysical principles and conditions. 相似文献
47.
Nicolas Stoiber Renaud Seguier Gaspard Breton 《Computer Animation and Virtual Worlds》2010,21(1):39-54
Expressive facial animations are essential to enhance the realism and the credibility of virtual characters. Parameter‐based animation methods offer a precise control over facial configurations while performance‐based animation benefits from the naturalness of captured human motion. In this paper, we propose an animation system that gathers the advantages of both approaches. By analyzing a database of facial motion, we create the human appearance space. The appearance space provides a coherent and continuous parameterization of human facial movements, while encapsulating the coherence of real facial deformations. We present a method to optimally construct an analogous appearance face for a synthetic character. The link between both appearance spaces makes it possible to retarget facial animation on a synthetic face from a video source. Moreover, the topological characteristics of the appearance space allow us to detect the principal variation patterns of a face and automatically reorganize them on a low‐dimensional control space. The control space acts as an interactive user‐interface to manipulate the facial expressions of any synthetic face. This interface makes it simple and intuitive to generate still facial configurations for keyframe animation, as well as complete temporal sequences of facial movements. The resulting animations combine the flexibility of a parameter‐based system and the realism of real human motion. Copyright © 2010 John Wiley & Sons, Ltd. 相似文献
48.
Daniel Coillot François O. Méar Renaud Podor Lionel Montagne 《Advanced functional materials》2010,20(24):4371-4374
A new process that enables glassy materials to self‐repair from mechanical damage is presented in this paper. Contrary to intrinsic self‐healing, which involves overheating to enable crack healing by glass softening, this process is based on an extrinsic effect produced by vanadium boride (VB) particles dispersed within the glass matrix. Self‐repair is obtained through the oxidation of VB particles, and thus without the need to increase the operating temperature. The VB healing agent is selected for its capacity to oxidize at a lower temperature than the softening point of the glass. Thermogravimetric analyses indeed show that VB oxidation is rapid and occurs below the glass transition temperature. Solid‐state nuclear magnetic resonance spectroscopy indicates that VB is oxidized into V2O5 and B2O3, which enable the local formation of glass. The autonomic self‐healing effect is demonstrated by an in situ experiment visualized using an environmental scanning electron microscope. It is shown that a crack could be healed by the VB oxidation products. 相似文献
49.
Olivier Perroud Renaud Vayrette Olivier Thomas Olivier Ulrich 《Microelectronic Engineering》2010,87(3):394-397
The mechanical properties of simple metals in small dimensions have been the objects of many studies. Average stress measurements clearly show that yield stress increases significantly when the size decreases but local strain measurements indicate considerable grain-to-grain and intra-grain strain variations. The link between the macroscopic behaviour of microstructures and the corresponding local processes is still difficult to analyse.Copper is used in advanced microelectronic interconnects and the mechanical properties of narrow interconnects is a key issue for the reliability of devices. Average strain measurements performed on line arrays show a drastically different behaviour in narrow lines as compared with wide lines. ST microelectronics in Rousset developed a MEMS sensor integrated in the damascene process to follow the stress after processing. This microsystem can be a very efficient tool to monitor the average stress in interconnects on the chip. The gradient of strain in interconnects may lead to failures from void and hillocks and local stress repartition can be obtained through X-ray microdiffraction. Laue microdiffration is a unique non-destructive method to investigate the strain grain-by-grain in microstructures. The diffraction patterns were obtained at ESRF on BM32 beam line. We present the first steps of the investigation of a MEMS investigated by Laue microdiffraction. The sub-micron X-ray-beam allows a mapping of the microstructure with a step of around 1 μm, which is also the value of the estimated grain size. We present results on the orientation and stress at a sub-micron scale obtained from the Laue-diffraction measurements on the MEMS. 相似文献
50.
All controlled radical polymerization (CRP) procedures rely on a dynamic and rapid equilibrium between dormant and active species. This equilibrium can be established through different mechanisms and all the resulting CRP processes have their own advantages and limitations. Therefore, it becomes interesting to investigate the possibility of combining CRP techniques to eliminate specific drawbacks of each individual procedure. Atom transfer radical polymerization (ATRP) with alkyl pseudohalides acting as initiators and chain transfer agents was developed for that purpose. The process relies on a dual mechanism involving both activation deactivation and reversible addition fragmentation chain transfer (RAFT). This peculiar characteristic of ATRP with alkyl pseudohalides acting as chain transfer agents made it possible to overcome some of the limitations typically associated with conventional ATRP and RAFT polymerization as well as to prepare new responsive materials. 相似文献