Numerical Simulation of Fire Exposed Façades Using LEPIR II Testing Facility

The fire behavior of external wall insulation system on façades is assessed during LEPIR II testing. This facility involves a 600 kg wood crib fire in a 30 m³ lower compartment of a two levels high concrete structure. External flames develop in front of the façade from the fire compartment through windows with dimensions 1?×?1.5 m (W?×?H). In order to predict the fire exposure of a façade during the test, CFD simulations were carried out with the computational fluid dynamics code Fire Dynamics Simulator (FDS) for two full-scale experiments. The main objective of this study was to evaluate the ability of FDS to reproduce quantitative results in terms of gas temperatures and heat fluxes close to the tested façade. This is an important step before the fire performances of any insulation system can be predicted by numerical tools. A good repeatability was observed in terms of measured gas temperatures for experiments. Maximum heat release rate of the fire, close to 5 MW, was achieved after 5 min of test. When experimental results were compared with numerical calculations, good agreement was found for every quantity. The most critical zone on the facade is located above the fire room and is directly impacted by external flame outgoing from the fire compartment. Temperatures up to 500°C were observed in this zone. For the thermocouples located up to the second level opening, these probes were not located directly in the flames, but rather in the hot gases above the fire plume. The maximum temperature achieved was thus close to 400°C. The proposed model gives correct thermal loads and flames shape near the façade during calibration tests and can be used for further evaluation of combustible material on façade.     

Broad-band diode-pumped ytterbium-doped fiber amplifier with 34-dBmoutput power

We investigate a high-power diode-pumped double-clad ytterbium-doped fiber amplifier with 34-dBm average output power and 1050-1095-nm bandwidth. A multidiode concentrator pumps the amplifier at 980 nm, with ~6 W of power launched into the inner cladding. Besides CW-signals, we amplify pulses from a mode-locked laser to 1 kW of peak power with only minor nonlinear distortions as well as pulses from a Q-switched laser to 50 μJ of energy. Reflections and backscatter limit the gain of the amplifier to 40 dB for a pump power of 2.5 W. For higher pump-powers than this, the amplifier started to self-Q-switch. The results are important for the development of cladding-pumped high-power fiber amplifiers     

Combining Program and Data Specialization

Program and data specialization have always been studied separately, although they are both aimed at processing early computations. Program specialization encodes the result of early computations into a new program; while data specialization encodes the result of early computations into data structures.In this paper, we present an extension of the Tempo specializer, which performs both program and data specialization. We show how these two strategies can be integrated in a single specializer. This new kind of specializer provides the programmer with complementary strategies which widen the scope of specialization. We illustrate the benefits and limitations of these strategies and their combination on a variety of programs.     

A risk-benefit assessment of pharmacotherapies for clinical depression in children and adolescents

Child and adolescent major depressive disorders are common and recurrent disorders. The prevalence of major depressive disorders is estimated to be approximately 2% in children and 4 to 8% in adolescents. Major depressive disorders in children are frequently accompanied by other psychiatric disorders, poor psychosocial outcome and a high risk of suicide and substance abuse, indicating the need for effective treatment and prevention. The use of antidepressant medications as the first line of treatment for children and adolescents with mild to moderate major depressive disorders has been questioned. However, some subgroups of patients may benefit from initial treatment with antidepressants. These subgroups may include patients who are unwilling or unable to undergo psychotherapy, have not responded to at least 8 to 12 sessions of psychotherapy, have bipolar, atypical or severe depression or have recurrent depression. Currently, the selective serotonin (5-hydroxytryptamine; 5-HT) reuptake inhibitors are the first medication choice because of their efficacy, benign adverse effect profile, ease of use and low risk of death following an overdose. Further research in continuation and maintenance treatments, treatment of comorbid conditions, subtypes of depression, e.g. bipolar, atypical, seasonal, and combinations of pharmacotherapy and psychotherapy are needed. In addition, studies of the pharmacokinetics, pharmacodynamics and long term adverse effects of antidepressant medications in children and adolescents are warranted.     

Palladium‐Catalyzed Synthesis of Functional Tetralins via Benzylic Activation

2‐Monosubstituted, 2,2‐ and 2,3‐disubstituted tetralin derivatives have been synthesized from α,α′‐dihalo‐o‐xylenes and activated olefins using a palladium catalyst under basic conditions. The effects of temperature, base, palladium precursor and solvent have been fully explored, and this new catalytic reaction has been extended to a variety of substrates.     

Three scale modeling of the behavior of a 16MND5-A508 bainitic steel: Stress distribution at low temperatures

An original approach is proposed to predict the behavior of the 16MND5 bainitic steel (similar to U.S. A508 cl.3) in the lower range of the ductile-to-brittle transition region and at lower temperatures [−196 °C; 20 °C], by developing a new polycrystalline modeling concurrently with X-ray diffraction (XRD) analysis. A two-level homogenization is used to take into account each kind of heterogeneity as well as the phase and grain interactions. A Mori–Tanaka formulation first enables to describe the elastoplastic behavior of a bainitic single crystal (modeled as a single crystal ferritic matrix reinforced by cementite inclusions), while the transition to polycrystal is achieved by a self-consistent approach. This model can simulate in particular the effects of temperature. It reproduces qualitatively the stress distribution in the material (stress states are lower in ferrite than in the bulk material due to cementite particles, the difference never exceeding 150 MPa), the intergranular strain heterogeneity (ripples observed on the _ψ = f(sin² ψ) curve) and the pole figures determined by XRD on different scales. The proposed approach is validated here on the macroscopic, phase and intraphase scale.     

Demonstration of 20 Gbit/s all-optical logic XOR in integratedSOA-based interferometric wavelength converter

The results of optical logic exclusive-OR (XOR) at up to 20 Gbit/s in an integrated SOA-based Mach-Zehnder interferometer are presented. For the first time, to the knowledge of the authors, BER measurements are demonstrated on 10 Gbit/s optical logic XOR, with zero penalty. In addition. For the first time 20 Gbit/s all-optical XOR, with an integrated device that allows simple, stable, and efficient operation, is demonstrated     

Saccharomyces cerevisiae boulardii CNCM I-1079 affects health,growth, and fecal microbiota in milk-fed veal calves

The objective of this study was to investigate the effect of one specific strain of yeast, Saccharomyces cerevisiae boulardii CNCM I-1079 (SCB), on the growth performance, health, and fecal bacterial profile of veal calves. A total of 84 animals were enrolled in an experiment at a commercial veal farm for a total of 7 wk. Calves were fed twice a day with a milk replacer meal during the entire experiment and were randomly assigned to receive daily either SCB supplementation (10 × 10⁹ cfu/d) or a placebo (CON). Individual feed intake and body weight were monitored on a daily and weekly basis, respectively. Fecal samples were collected at arrival to the veal facility (wk 0) and additional samples were taken on d 14 (wk 2) and d 49 (wk 7). These samples were subjected to 16S rRNA gene amplicon sequencing using Illumina MiSeq (Illumina Inc., San Diego, CA) to examine the bacterial profiles and real-time quantitative PCR to quantify Saccharomyces cerevisiae and specific bacterial groups. The significant increase of S. cerevisiae in the feces of SCB calves at wk 2 and 7 compared with wk 0 (respectively 1.7 × 10⁷, 1.2 × 10⁷, and 2.2 × 10⁵ copy number of S. cerevisiae/g of feces) indicates a good survival of that yeast strain along the gastrointestinal tract. Supplementation of SCB did not improve overall growth performance with regard to average daily gain (ADG), final body weight, and feed intake. Nevertheless, a total of 69.1% of nonsupplemented calves had diarrhea and 28.6% experienced severe diarrhea, whereas 50.0% of the calves supplemented with SCB had diarrhea and 9.5% experienced severe diarrhea. With respect to antibiotic use, 89.7% of the diarrheic calves recorded in the CON group were treated, whereas only 66.7% of the SCB diarrheic calves received an antibiotic. In addition, diarrheic calves supplemented with SCB maintained an ADG similar to nondiarrheic animals, whereas the CON diarrheic calves had a significantly lower ADG in comparison with nondiarrheic CON calves. Fecalibacterium was the most predominant bacterial genus in fecal samples of nondiarrheic and diarrheic calves supplemented with SCB, whereas fecal microbiota was predominated by Collinsella in diarrheic calves from the CON group. Live yeast supplementation in milk replacer led to a decrease of diarrhea in milk-fed veal calves and the fecal microbiota of diarrheic calves maintained a healthy community similar to nondiarrheic animals, with Fecalibacterium being the predominant genus.     

Lipid biosynthesis in cultured arterial smooth muscle cells is related to their phenotype

During the atherogenic processin vivo, arterial smooth muscle cells (SMC) undergo changes in their phenotype. In the present study, rat SMC from primary cultures and from subcultures before 10 and after 200 passages, showing contractile-like, synthetic and transformed phenotypes, respectively, were compared in regard to their lipid content and biosynthesis. The rationale for comparing these phenotypes rests in the similar changes in phenotype of SMC that occur in the formation and progression of atherosclerotic lesions. Phenotype changes were shown to be associated with changes in the phospholipid content of SMC. Phospholipid levels increased, but not as significantly as did cholesterol levels when passing from contractile to synthetic and transformed cells (1.23±0.18, 2.28±0.26 and 3.25±0.23 μg/10⁶ cells, respectively). Cholesterol normalized in respect to cell protein was increased to the same extent. Lipid synthesis as judged by [¹⁴C]acetate incorporation was increased 3- to 12-fold in the synthetic and transformed cells, respectively, compared to contractile cells. After thin-layer chromatography, radioactivity was shown to be markedly increased in most of the lipid fractions, but label in the cholesterol fraction of synthetic and transformed cells was increased by 7- and 21-fold, respectively. Thus, SMCin vitro were shown to drastically increase cholesterol biosynthesis associated with phenotype changes. Such changes are known to occurin vivo and might represent a critical step in the deposition of excess cholesterol within foam cells.     

The effect of lung consolidation,as determined by ultrasonography,on first-lactation milk production in Holstein dairy calves

Bovine respiratory disease (BRD) is a complex disease process and many reports emphasize the negative implications of clinical BRD in dairy calves. Early diagnosis can be difficult because of inconsistent or absent clinical signs; however, the use thoracic ultrasonography has the potential to improve detection of respiratory disease. Earlier detection of BRD may result in actions to improve calf welfare and production. The objective of this prospective cohort study was to determine if lung consolidation (LC) in young dairy calves influenced age at first calving (AFC), first-lactation milk production, and survival to the end of first lactation. A total of 215 female calves from 3 dairy herds in southwestern Ontario were enrolled and assessed weekly during their first 8 wk of life for evidence of LC using thoracic ultrasonography (Ibex Pro, Loveland, CO). Consolidation was measured, using gridlines on the screen of the ultrasound, in the first 10 intercostal spaces on both sides of the thorax. Calves were considered LC positive if ≥3 cm of consolidated lung was present. Multivariable linear regression models were used to identify risk factors associated with AFC and first-lactation 305-d milk production. A survival analysis was conducted to determine differences in survival from enrolment until the end of first lactation between calves with and without consolidation. In the study population, the following calfhood conditions were detected: twins (4%; n = 8), diarrhea in the first 21 d of life (31%; n = 66), rib fractures (7%; n = 14), lung abscesses (3%; n = 6), and at least one diagnosis of LC (57%; n = 123). Overall, 7% (n = 15) of calves died, and 18% (n = 38) of animals were sold before the end of first lactation. The presence of LC, at least once in the first 8 wk of life, did not influence AFC, but did result in a 525 kg (95% confidence interval: ?992.81 to ?60.25) decrease in first-lactation 305-d milk production. No difference in survival was detected between LC groups. These results indicate that LC during the first 56 d of life has a long-term effect on dairy calves, manifested as reduced milk production during first lactation.