Synthesis and applications of heterobifunctional poly(ethylene oxide) oligomers

Poly(ethylene oxide) (PEO) oligomers are employed extensively in pharmaceutical and biomedical arenas mainly due to their excellent physical and biological properties, including solubility in water and organic solvents, lack of toxicity, and absence of immunogenicity. PEO can be chemically modified and reacted with, or adsorbed onto, other molecules and surfaces. Sophisticated applications for PEO have increased the demand for PEO oligomers with tailored functionalities, and heterobifunctional PEOs are often needed. This review discusses the synthesis and applications of heterobifunctional PEO oligomers possessing amine, carboxylate, thiol, and maleimide functional groups.     

A strategy for the electro-organic synthesis of new hydrocaffeic acid derivatives

Electrochemical treatment processes can significantly contribute to the protection of the environment through the minimization of waste and toxic materials in effluents. From a pharmaceutical point of view and due to the existing resemblance between the electrochemical and biological reactions, it can be assumed that the oxidation mechanisms on the electrode and in the body share similar principles. In this paper, the application of electrochemical studies in the design of an environmentally friendly method was delineated for the new hydrocaffeic acid (HCA, 3,4-dihydroxy hydrocinnamic acid) derivatives synthesis at carbon electrodes in an undivided cell. In this cell, the EC mechanism reaction was involved, comprising two steps alternatively; (1) electrochemical oxidation and (2) chemical reaction. In particular, the electro-organic reactions of HCA, an important biological molecule, were studied in a water–acetonitrile (90:10 v/v) mixture in the presence of benzenesulfinic acid (3) and p-toluenesulfinic acid (4). The research included the use of a variety of experimental techniques, such as cyclic voltammetry, controlled-potential electrolysis and product spectroscopic identification.     

Stability analysis of network-based cooperative resource allocation strategies

Resource allocation involves deciding how to divide a resource of limited availability among multiple demands in a way that optimizes current objectives. In this brief paper we focus on one type of distributed resource allocation problem where via an imperfect communication network multiple processors can share the load presented by multiple task types. We introduce asynchronous “cooperative” resource allocation strategies, and show that they lead to a bounded cumulative demand.     

Nonpathological Lyapunov functions and discontinuous Carathéodory systems

Differential equations with discontinuous right-hand side and solutions intended in Carathéodory sense are considered. For these equations, sufficient conditions which guarantee both Lyapunov stability and asymptotic stability in terms of nonsmooth Lyapunov functions are given. An invariance principle is also proven.     

Bullwhip reduction for ARMA demand: The proportional order-up-to policy versus the full-state-feedback policy

A ‘proportional’ order-up-to policy reacting to ARMA demand is analyzed using stochastic optimal control theory. This policy is compared with a full-state-feedback order-up-to policy. Necessary conditions for an optimum of a weighted sum of the inventory and the ordering variances for both policies are formulated. Based on this a relatively simple expression for the ‘full-state’ policy is derived. The comparison between the two policies demonstrates that the ‘intuitively’ designed proportional policy does not fulfill the objective of controlling both the inventory and ordering variance for all parameter values of the demand model as well as the full-state-feedback policy. The full-state-feedback policy outperforms the proportional policy in several aspects.     

Subspace distance analysis with application to adaptive Bayesian algorithm for face recognition

We propose subspace distance measures to analyze the similarity between intrapersonal face subspaces, which characterize the variations between face images of the same individual. We call the conventional intrapersonal subspace average intrapersonal subspace (AIS) because the image differences often come from a large number of persons. An intrapersonal subspace is referred to as specific intrapersonal subspace (SIS) if the image differences are from just one person. We demonstrate that SIS varies significantly from person to person, and most SISs are not similar to AIS. Based on these observations, we introduce the maximum a posteriori (MAP) adaptation to the problem of SIS estimation, and apply it to the Bayesian face recognition algorithm. Experimental results show that the adaptive Bayesian algorithm outperforms the non-adaptive Bayesian algorithm as well as Eigenface and Fisherface methods if a small number of adaptation images are available.     

Cramer-Rao lower bound on locations of sudden changes in a steplikesignal

Estimation of locations of sudden changes in a steplike signal has many signal processing applications; e.g., well-log signal segmentation, ionic-channel signal classification, edge detection, and segmentation of images. In this work, the Cramer-Rao lower bound (CRLB) on locations of steps in one-dimensional (1-D) steplike signals is calculated. The calculation is based on the use of a sigmoidal function to model a sudden-change (step) in the signal. The introduced model has an adjustable parameter that can be used to fit the CRLB calculation to a particular class of steplike signals     

An empirical investigation of competency factors affecting e-business success in European SMEs

In the last decade there was growing interest in strategic management literature about factors that influence a company's ability to use IT. There is general consensus that knowledge and competency are necessary in developing an IT capability, but there is very little understanding of what the necessary competencies are, and how they influence IS usage in different contexts. The small and medium-sized enterprise context is particularly interesting for two reasons: it constitutes a major part of the economy and it has been relatively unsuccessful in exploiting e-business.