Spiral-CT-based assessment of tracheal stenoses using 3-D-skeletonization

PURPOSE: Demonstration of a technique for three-dimensional (3-D) assessment of tracheal-stenoses, regarding site, length and degree, based on spiral computed tomography (S-CT). PATIENTS AND METHODS: S-CT scanning and automated segmentation of the laryngo-tracheal tract (LTT) was followed by the extraction of the LTT medial axis using a skeletonization algorithm. Orthogonal to the medial axis the LTT 3-D cross-sectional profile was computed and presented as line charts, where degree and length was obtained. Values for both parameters were compared between 36 patients and 18 normal controls separately. Accuracy and precision was derived from 17 phantom studies. RESULTS: Average degree and length of tracheal stenoses was found to be 60.5% and 4.32 cm in patients compared with minor caliber changes of 8.8% and 2.31 cm in normal controls (p < 0.0001). For the phantoms an excellent correlation between the true and computed 3-D cross-sectional profile was found (p < 0.005) and an accuracy for length and degree measurements of 2.14 mm and 2.53% respectively could be determined. The corresponding figures for the precision were found to be 0.92 mm and 2.56%. CONCLUSION: LTT 3-D cross-sectional profiles permit objective, accurate and precise assessment of LTT caliber changes. Minor LTT caliber changes can be observed even in normals and, in case of an otherwise normal S-CT study, can be regarded as artifacts.     

Cellular fluorescent indicators and voltage/ion probe reader (VIPR) tools for ion channel and receptor drug discovery

High throughput functional assays are increasingly relied upon to generate early and novel discovery leads for drug development. Ion transport proteins including channels, transporters, and pumps play central roles in cellular bioenergetics, excitability, and a multitude of other biological functions. Facile, robust methods for detecting ion transport activity in both native and heterologous systems is desirable for rapid functional analysis and drug discovery for these difficult but important targets. Here we discuss cell-compatible fluorescent probes, functional assays, and VIPR instrumentation that are used to monitor real-time target activity and screen large chemical libraries for potent and selective modulators. Advances and issues for both exogenously applied and fluorescent protein probes of cellular membrane potential, Ca2+, Cl-, and pH are addressed. High throughput screening (HTS) compatible, rapid kinetic and fluorescence resonance energy transfer (FRET) assays are emphasized, in particular the use of voltage-sensitive FRET probes to assay ion channel activity in single cells and 96/384-well formats.     

Intrinsic selectivities and yields in the catalytic hydrogenation of polyenoic fatty acid methyl esters

Precise values of the intrinsic selectivities and yields for the hydrogenation products of methyl linolenate (Ln) and methyl linoleate (L) obtained under carefully controlled conditions using a commercial Ni catalyst are presented and analyzed in detail. The existence of a preferential adsorption of Ln and a significant co-hydrogenation of its double bonds are confirmed as being the dominant features under typical vegetable oil processing conditions. It is shown that the values of the selectivities that are obtained from the classical consecutive reactions network account for the intrinsic selectivity of the catalyst only while hydrogenating feedstocks with moderate to low (<10%) contents of Ln. Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Universidad Nacional del Lltoral (U.N.L.)     

D2D pervasive communication system with out-of-band control autonomous to 5G networks

Wireless Networks - D2D (device-to-device) communication is one of the developments of 5G networks (5th generation mobile networks) that reduce mobile traffic load, reduce energy consumption and...     

A data mining approach to classify serum creatinine values in patients undergoing continuous ambulatory peritoneal dialysis

Wireless Networks - Continuous ambulatory peritoneal dialysis (CAPD) is a treatment used by patients in the end-stage of chronic kidney diseases. Those patients need to be monitored using blood...     

An efficiently implementable maximum likelihood decoding algorithm for tailbiting codes

Convolutional tailbiting codes are widely used in mobile systems to perform error-correcting strategies of data and control information. Unlike zero tail codes, tailbiting codes do not reset the encoder memory at the end of each data block, improving the code efficiency for short block lengths. The objective of this work is to propose a low-complexity maximum likelihood decoding algorithm for convolutional tailbiting codes based on the Viterbi algorithm. The performance of the proposed solution is compared to that of another maximum likelihood decoding strategy which is based on the A* algorithm. The computational load and the memory requirements of both algorithms are also analysed in order to perform a fair comparison between them. Numerical results considering realistic transmission conditions show the lower memory requirements of the proposed solution, which makes its implementation more suitable for devices with limited resources.     

Multicast deflector

Technological evolution is leading telecommunications toward all-IP scenarios, where multiple services are transported as IP packets. Among these services is the broadcast of video. A possible mechanism for broadcasting multiple video channels over IP is to use IP multicast, and let each client decide about the reception of a channel. The secure IP multicast specified by the IETF MSEC working group is a candidate solution for securing these broadcast services. In this paper we propose a new solution for supporting the broadcast of multiple video channels which can be accessed only by authorized users; besides, when a video channel is not visualized in the last mile its transmission is temporarily suspended, so that the cable can be used for other services such as standard Internet access.