Seroprotective groups among isolates of Borrelia burgdorferi

We demonstrated that different seroprotective groups exist among isolates of Borrelia burgdorferi and Borrelia garinii. The major group was composed of isolates 297, B31, S-1-10, MMTI, IPT, and ATCC 35211 and 21 isolates obtained from California, Illinois, New York, Texas, and Wisconsin. A second group was composed of European isolates PBi and G25. A third group was composed of a single isolate, C-1-11. These groupings were supported by Western immunoblot findings. In addition, the seroprotective groups were confirmed by passive transfer of immune sera and challenge of recipient hamsters with the homologous isolate or other isolates of B. burgdorferi or B. garinii. These studies demonstrate that a monovalent vaccine will not provide complete protection against infection with all isolates of B. burgdorferi.     

Comparison of formation of D2/E2-isoprostanes and F2-isoprostanes in vitro and in vivo--effects of oxygen tension and glutathione

Rats with extensive ibotenic acid lesions centered in the gustatory zone of the pontine parabrachial nucleus (PBN) failed to acquire a conditioned taste aversion (CTA) induced by lithium chloride (LiCl) toxicosis (Experiments 1 and 4). This deficit cannot be explained as an inability to either perceive or process gustatory information because lesioned rats that failed to acquire a CTA readily acquired a conditioned flavor preference (Experiment 2). Similarly, the CTA deficit cannot be attributed to an inability to experience or process visceral input because PBN-lesioned rats that failed to acquire a CTA successfully learned an aversion to a trigeminal stimulus, capsaicin, when paired with LiCl-induced illness (Experiment 3). This pattern of results supports the view that cell bodies within the PBN are essential for the associative processes that govern CTA learning.     

Influence of feed deprivation on ventilation and gas exchange in broilers: relationship to pulmonary hypertension syndrome

Fast-growing broiler chickens not uncommonly exhibit elevated pulmonary vascular resistance that leads to pulmonary hypertension and right ventricular failure. We tested the hypothesis that a distended gastrointestinal tract in these full-fed birds results in an abnormally low tidal volume and minute ventilation that could lead to pulmonary hypoxia, pulmonary arterial vasoconstriction, right ventricular failure, and ascites. Tidal volume, respiratory frequency, heart rate, percentage saturation of hemoglobin with oxygen (HbO2), O2 consumption, and carbon dioxide elimination were measured on fast-growing broiler chickens when full-fed and after 3, 6, and 9 h of feed deprivation. Tidal volume of full-fed birds was not abnormally low despite HbO2 values varying from above 80% to nearly 60%. Importantly, HbO2 was found to be markedly increased in the hypoxemic birds at and beyond a 3-h period without feed, despite a reduction in minute ventilation. This response was not caused by a decrease in O2 consumption. Thus, limitation of gas intake at the mouth was not the cause of the hypoxemia. The data suggest that feed deprivation results in an increase in parabronchial ventilation, possibly from improvement in aerodynamic valving, which would reduce pulmonary hypoxic vasoconstriction and right ventricular failure.     

Primitives used in the spatial localization of nonabutting stimuli: peaks or centroids

In order to determine whether simple luminance profiles are located by their peaks or centroids we performed a three element alignment task where the central element's degree of luminance asymmetry was randomly chosen from a flat distribution (skew noise). The central element with its randomly chosen skew was either positioned using the peak or centroid of its distribution. Accuracy is invariant with the magnitude of the skew noise for the centroid but not the peak condition. We conclude that the human visual system assigns position tags using centroids not peaks of luminance distributions for gabors. However this is not the case for Gaussian blobs, where a measure closer to the midpoint is used for our stimulus arrangement.     

Balloon catheter tamponade of exsanguinating facial hemorrhage: a case report

A 42-year-old man sustained a gunshot wound to the frontal process of the left maxilla just lateral to the nasal bone medial to the maxilla that caused profuse hemorrhage. Anterior and posterior nasal packing along with packing of the gunshot wound with Vaseline gauze did not control the hemorrhage. A 28 French (30-cc balloon) Foley catheter was placed directly into the wound, and bleeding stopped immediately upon inflation of the balloon with 30 cc of sterile water. Arteriography identified bleeding from an anterior branch of the maxillary artery that was successfully embolized.