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排序方式: 共有1014条查询结果,搜索用时 15 毫秒
91.
Yves Nicolas Marcel Paques Dirk van den Ende Jan K. G. Dhont Rob C. van Polanen Alexandra Knaebel Alain Steyer Jean-Pierre Munch Theo B. J. Blijdenstein George A. van Aken 《Food Hydrocolloids》2003,17(6):907
Three configurations have been developed to improve the understanding of structural element interactions in food material during deformation. The three configurations combine an inverted confocal scanning laser microscope (CSLM) and a cell that can apply to the sample a specific deformation: continuous shear, linear oscillatory shear and biaxial extension (compression).In the continuous shear and oscillatory shear configurations (OSCs), a zero-velocity plane is created in the sample by moving two plates in opposite direction, maintaining stable observation conditions of the structural behaviour under deformation. The OSC allows simultaneous application of CSLM and diffusing wave spectroscopy, a multiple light scattering technique. The third configuration (compression configuration) allows observation at a stagnation point during rheometric measurements. The configurations accept semi-liquid products (dressing, sauces, dairy products, etc.) for investigations in area such as aggregation, gelation, interactions at interface, coalescence, break-up. 相似文献
92.
Biosecurity Measures to Control Salmonella and Other Infectious Agents in Pig Farms: A Review 下载免费PDF全文
Victor M. Andres Rob H. Davies 《Comprehensive Reviews in Food Science and Food Safety》2015,14(4):317-335
Salmonellosis is the 2nd most common cause of human bacterial food poisoning and can be acquired from meat or eggs, either via direct consumption or cross‐contamination in the kitchen. The European Commission has set the criteria to control Salmonella infections within the poultry sector and it is proposed that the swine sector should follow. Pork is considered, after eggs, the major source of infection in humans in the EU, with Salmonella typhimurium, including monophasic strains, being frequently implicated. Good control measures at the farm level are likely to correspond with lower prevalence of Salmonella infection and, subsequently, a reduction of cross‐contamination of carcasses processed at the slaughterhouse and a reduction in human salmonellosis. This review focuses on biosecurity measures in pig farms that can help to control important pig diseases at the same time as reducing the within‐herd prevalence of Salmonella. This information is likely to provide an economic incentive for farmers to apply improved general standards of farm biosecurity and hygiene management that would have a positive impact in food safety. 相似文献
93.
Thorpe KL Cummings RI Hutchinson TH Scholze M Brighty G Sumpter JP Tyler CR 《Environmental science & technology》2003,37(6):1142-1149
The natural steroids estradiol-17beta (E2) and estrone (E1) and the synthetic steroid ethynylestradiol-17alpha (EE2) have frequently been measured in waters receiving domestic effluents. All of these steroids bind to the estrogen receptor(s) and have been shown to elicit a range of estrogenic responses in fish at environmentally relevant concentrations. At present, however, no relative potency estimates have been derived for either the individual steroidal estrogens or their mixtures in vivo. In this study the estrogenic activity of E2, E1, and EE2, and the combination effects of a mixture of E2 and EE2 (equi-potent fixed-ratio mixture), were assessed using vitellogenin induction in a 14-day in vivo juvenile rainbow trout screening assay. Median effective concentrations, relative to E2, for induction of vitellogenin were determined from the concentration-response curves and the relative estrogenic potencies of each of the test chemicals calculated. Median effective concentrations were between 19 and 26 ng L(-1) for E2, 60 ng L(-1) for E1, and between 0.95 and 1.8 ng L(-1) for EE2, implying that EE2 was approximately 11 to 27 times more potent than E2, while E2 was 2.3 to 3.2 times more potent than E1. The median effective concentration, relative to E2, for the binary mixture of E2 and EE2 was 15 ng L(-1) (comprising 14.4 ng L(-1) E2 and 0.6 ng L(-1) EE2). Using the model of concentration addition it was shown that this activity of the binary mixture could be predicted from the activity of the individual chemicals. The ability of each individual steroid to contribute to the overall effect of a mixture, even at individual no-effect concentrations, combined with the high estrogenic potency of the steroids, particularly the synthetic steroid EE2, emphasizes the need to consider the total estrogenic load of these chemicals in our waterways. 相似文献
94.
Schopler John; Insko Chester A.; Wieselquist Jennifer; Pemberton Michael; Witcher Betty; Kozar Rob; Roddenberry Chris; Wildschut Tim 《Canadian Metallurgical Quarterly》2001,80(4):632
The related goals of the research were to delineate the domain of discontinuity, 1st by demonstrating its occurrence in a nonmatrix situation and, 2nd, by establishing the antecedent outcome conditions necessary for producing a discontinuity effect. The 1st goal was met by designing a mixed motive situation involving the production of origami products. Under these conditions, the magnitude of the discontinuity effect did not significantly differ from that in a matrix-only condition. The 2nd goal was met by a separate experiment that used H. H. Kelley and J. W. Thibaut's (1978) analysis of degree of noncorrespondence of outcomes. This experiment demonstrated that as noncorrespondence increased, so did the rate of competitive responding by groups but not by individuals. This pattern was qualified by an interaction with gender such that competitiveness was more markedly affected by noncorrespondence for groups of women than for groups of men. (PsycINFO Database Record (c) 2010 APA, all rights reserved) 相似文献
95.
96.
A surprising amount of collaboration and research can be quickly and inexpensively accomplished through the use of the Internet.
Indeed, a wealth of quality information has become available through this new medium in just a few years. This article examines
the practical utility of the Internet for materials scientists and engineers.
Editor’s Note: In our April 1995 issue, we presented the paper “Understanding the Internet: A Guide for Materials Scientists and Engineers”
by Kenneth J. Meltsner. While the scope of this article was broad and timely, much about the Internet has changed in the nearly
three years since the article was written and published. Hence, an update on this emerging tool for materials scientists and
engineers is more than required.
Rob M. Johnston earned his B.Sc. in materials and metallurgical engineering at Queen’s University in 1994. He is currently a consultant at
Qualisult Management Consultants. 相似文献
97.
98.
Anastasia Parchina Prof. Dr. Matheus Froeyen Lia Margamuljana Prof. Dr. Jef Rozenski Dr. Steven De Jonghe Dr. Yves Briers Prof. Dr. Rob Lavigne Prof. Dr. Piet Herdewijn Prof. Dr. Eveline Lescrinier 《ChemMedChem》2013,8(8):1373-1383
The urgent need for new antibiotics poses a challenge to target un(der)exploited vital cellular processes. Thymidylate biosynthesis is one such process due to its crucial role in DNA replication and repair. Thymidylate synthases (TS) catalyze a crucial step in the biosynthesis of thymidine 5‐triphosphate (TTP), an elementary building block required for DNA synthesis and repair. To date, TS inhibitors have only been successfully applied in anticancer therapy due to their lack of specificity for antimicrobial versus human enzymes. However, the discovery of a new family of TS enzymes (ThyX) in a range of pathogenic bacteria that is structurally and biochemically different from the “classic” TS (ThyA) has opened the possibility to develop selective ThyX inhibitors as potent antimicrobial drugs. Here, the interaction of the known inhibitor 5‐(3‐octanamidoprop‐1yn‐1yl)‐2′‐deoxyuridine‐5′‐monophosphate ( 1 ) with Mycobacterium tuberculosis ThyX enzyme is explored using molecular modeling starting from published crystal structures, with further confirmation through NMR experiments. While the deoxyuridylate (dUMP) moiety of compound 1 occupies the cavity of the natural substrate in ThyX, the rest of the ligand (the “5‐alkynyl tail”) extends to the outside of the enzyme between two of its four subunits. The hydrophobic pocket that accommodates the alkyl part of the tail is formed by displacement of Tyr 44.C, Tyr 108.A and Lys 165.A. Changes to the resonance of the Lys 165 NH3 group upon ligand binding were monitored in a titration experiment by 2D HISQC NMR. Guided by the results of the modeling and NMR studies, and inspired by the success of acyclic antiviral nucleosides, compounds where a 5‐alkynyl uracyl moiety is coupled to an acyclic nucleoside phosphonate (ANP) were synthesized and evaluated. Of the compounds evaluated, sodium (6‐(5‐(3‐octanamidoprop‐1‐yn‐1‐yl)‐2,4‐dioxo‐3,4‐dihydropyrimidin‐1(2H)‐yl)hexyl)phosphonate ( 3 e ) exhibited 43 % of inhibitory effect on ThyX at 50 μM . While only modest activity was achieved, this is the first example of an ANP inhibiting ThyX, and these results can be used to further guide structural modifications to this class to develop more potent compounds with potential application as antibacterial agents acting through a novel mechanism of action. 相似文献
100.
The increasing use of web 2.0 applications has generated numerous online user reviews. Prior studies have revealed the influence of user-generated reviews on the sales of products such as CDs, books, and movies. However, the influence of online user-generated reviews in the tourism industry is still largely unknown both to tourism researchers and practitioners. To bridge this knowledge gap in tourism management, we conducted an empirical study to identify the impact of online user-generated reviews on business performance using data extracted from a major online travel agency in China. The empirical findings show that traveler reviews have a significant impact on online sales, with a 10 percent increase in traveler review ratings boosting online bookings by more than five percent. Our results highlight the importance of online user-generated reviews to business performance in tourism. 相似文献