Diagnosing item score patterns on a test using item response theory-based person-fit statistics.

Person-fit statistics have been proposed to investigate the fit of an item score pattern to an item response theory (IRT) model. The author investigated how these statistics can be used to detect different types of misfit. Intelligence test data were analyzed using person-fit statistics in the context of the G. Rasch (1960) model and R. J. Mokken's (1971, 1997) IRT models. The effect of the choice of an IRT model to detect misfitting item score patterns and the usefulness of person-fit statistics for diagnosis of misfit are discussed. Results showed that different types of person-fit statistics can be used to detect different kinds of person misfit. Parametric person-fit statistics had more power than nonparametric person-fit statistics. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

按照最严格的环境法规进行生产

中国、韩国以及美国的部分州都有类似于欧洲RoHS指令的环境法规,这些法规之间存在很小的差别但这些差别却又是不容忽视的。之所以说重要是因为这些差别集中在豁免、报告、合格证明等关键的地方。各国或地区依据不同的环境法规,产生了不同的新规定,这使国际贸易情况变得更加复杂     

Identification of Phenylpyrazolone Dimers as a New Class of Anti-Trypanosoma cruzi Agents

Chagas disease is becoming a worldwide problem; it is currently estimated that over six million people are infected. The two drugs in current use, benznidazole and nifurtimox, require long treatment regimens, show limited efficacy in the chronic phase of infection, and are known to cause adverse effects. Phenotypic screening of an in-house library led to the identification of 2,2′-methylenebis(5-(4-bromophenyl)-4,4-dimethyl-2,4-dihydro-3H-pyrazol-3-one), a phenyldihydropyrazolone dimer, which shows an in vitro pIC₅₀ value of 5.4 against Trypanosoma cruzi. Initial optimization was done by varying substituents of the phenyl ring, after which attempts were made to replace the phenyl ring. Finally, the linker between the dimer units was varied, ultimately leading to 2,2′-methylenebis(5-(3-bromo-4-methoxyphenyl)-4,4-dimethyl-2,4-dihydro-3H-pyrazol-3-one (NPD-0228) as the most potent analogue. NPD-0228 has an in vitro pIC₅₀ value of 6.4 against intracellular amastigotes of T. cruzi and no apparent toxicity against the human MRC-5 cell line and murine cardiac cells.     

Binge-drinking-related consequences in college students: Role of drinking beliefs and mother–teen communications.

The present research contrasted theoretical models depicting the nature of the relation among drinking beliefs, drinking tendencies, and behavioral consequences in 266 incoming freshman college students. It also examined the theoretical relations between mother–teen communications and drinking beliefs relevant to behavioral consequences. The findings revealed direct relations between binge-drinking consequences and the drinking beliefs: Alcohol can make positive transformations, can enhance social behavior, and can increase negative affect and normative approval. Direct relations were not observed between consequences and the drinking beliefs regarding physical risk and health orientation. Finally, the present research found consistent support for the relation between mother–teen communications and drinking beliefs relevant to binge-drinking consequences. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Modeling climate change mitigation from alternative methods of charcoal production in Kenya

Current carbon accounting methodologies do not accommodate activities that involve emissions reductions from both land-use change and energy production. This paper analyzes the climate change mitigation potential of charcoal production in East Africa by examining the impact of changing both land management and technology. Current production in a major charcoal producing region of Kenya where charcoal is made as a by-product of land clearance for commercial grain production is modeled as the “business-as-usual” scenario. Alternative production systems are proposed based on coppice management of native or exotic trees. Improved kilns are also considered. Changes in aboveground, belowground, and soil carbon are modeled and two distinct baseline assessments are analyzed: one is based on a fixed area of land and one is based on the quantity of non-renewable fuel that is displaced by project activities. The magnitude of carbon emissions reductions varies depending on land management as well as the choice of carbonization technology. However, these variations are smaller than the variations arising from the choice of baseline methodology. The fixed-land baseline yields annualized carbon emission reductions equivalent to 0.5–2.8 tons per year (t y^?1) with no change in production technology and 0.7–3.5 t y^?1 with improved kilns. In contrast, the baseline defined by the quantity of displaced non-renewable fuel is 2–6 times larger, yielding carbon emissions reductions of 1.4–12.9 t y^?1 with no change in production technology and 3.2–20.4 t y^?1 with improved kilns. The results demonstrate the choice of baseline, often a political rather than scientific decision, is critical in assessing carbon emissions reductions.