CF-GGA: A grouping genetic algorithm for the cell formation problem

In manufacturing, the machine-part cell formation (MPCF) problem addresses the issues surrounding the formation of part families based on the processing requirements of the components, and the identification of machine groups based on their ability to process specific part families. Past research has shown that one key aspect of attaining efficient groupings of parts and machines is the block-diagonalization of the given machine-part (MP) incidence matrix. This paper presents and tests a grouping genetic algorithm (GGA) for solving the MPCF problem and gauges the quality of the GGA's solutions using the measurements of efficiency (Chandrasekharan and Rajagopalan 1986a) and efficacy (Kumar and Chandrasekharan 1990). The GGA in this study, CF-GGA, a grouping genetic algorithm for the cell formation problem, performs very well when applied to a variety of problems from the literature. With a minimal number of parameters and a straightforward encoding, CF-GGA is able to match solutions with several highly complex algorithms and heuristics that were previously employed to solve these problems.     

APPLICATIONS OF THE DRAZIN INVERSE TO THE HILL CRYPTOGRAPHIC SYSTEM. PART III.

In this part it is shown how the scalar unit coefficient a appearing in the W key formula (see Part I) can be replaced by an invertible matrix coefficient Γ. (A similar discussion with respect to the V key will appear In Part IV.) Various examples illustrate in detail the different procedures involved. Some examples in the encipherment and decipherment calculations are left as problems for the reader. The Appendix contains a proof of the main theorem.     

On Jonckheere's k-Sample Test Against Ordered Alternatives

In this paper a k-sample non-parametric test for trend is considered. Given a sample of size n_i , i = 1, …, k respectively from each of k populations, the test rejects the hypothesis that the k populations are identical if S = Σ ^k _i=2 S_i ≥ S_i . Here Si is the Mann-Whitney statistic computed when each observation in the i-th sample is compared with the combined observations from the first (i – 1) populations. A recurrence formula is derived for computing the exact distribution of S. Tables of exact probabilities and critical values are given for nominal values of α = 0.5, 0.2, 0.1, 0.05, 0.025, 0.01, and 0.005 for k = 3 and all possible sample sizes from 2 to 8, and for equal sample sizes for values of n = 2(1)6, k = 4(1)6.     

Material Transfer Inside Head Disk Interface for Heat Assisted Magnetic Recording

Heat assisted magnetic recording (HAMR) promises to deliver higher storage areal density than the current perpendicular magnetic recording products. Laser heating is implemented in HAMR to achieve magnetic writing of the very high coercivity media. However, the high temperature environment creates several reliability challenges for the head disk interface (HDI). In this paper, material transfer within the HDI under HAMR recording conditions is studied. The mechanisms of material transfer are explored via experiments and modeling. This study revealed that temperature difference and mechanical interaction between the head and media are the main mechanisms for material transfer inside the HDI. Possible methods to remove the material are also discussed in this paper.     

Amphiphilic drug interactions with model cellular membranes are influenced by lipid chain-melting temperature

Small-molecule amphiphilic species such as many drug molecules frequently exhibit low-to-negligible aqueous solubility, and generally have no identified transport proteins assisting their distribution, yet are able to rapidly penetrate significant distances into patient tissue and even cross the blood–brain barrier. Previous work has identified a mechanism of translocation driven by acid-catalysed lipid hydrolysis of biological membranes, a process which is catalysed by the presence of cationic amphiphilic drug molecules. In this study, the interactions of raclopride, a model amphiphilic drug, were investigated with mixtures of biologically relevant lipids across a range of compositions, revealing the influence of the chain-melting temperature of the lipids upon the rate of acyl hydrolysis.     

The Urban Crisis

Advocacy and social responsibility of the profession, of the ACSA and the elements of the new curriculum in architectural education.     

Alterations in gap junction connexin43/connexin45 ratio mediate a transition from quiescence to excitation in a mathematical model of the myometrium

The smooth muscle cells of the uterus contract in unison during delivery. These cells achieve coordinated activity via electrical connections called gap junctions which consist of aggregated connexin proteins such as connexin43 and connexin45. The density of gap junctions governs the excitability of the myometrium (among other factors). An increase in gap junction density occurs immediately prior to parturition. We extend a mathematical model of the myometrium by incorporating the voltage-dependence of gap junctions that has been demonstrated in the experimental literature. Two functional subtypes exist, corresponding to systems with predominantly connexin43 and predominantly connexin45, respectively. Our simulation results indicate that the gap junction protein connexin45 acts as a negative modulator of uterine excitability, and hence, activity. A network with a higher proportion of connexin45 relative to connexin43 is unable to excite every cell. Connexin45 has much more rapid gating kinetics than connexin43 which we show limits the maximum duration of a local burst of activity. We propose that this effect regulates the degree of synchronous excitation attained during a contraction. Our results support the hypothesis that as labour approaches, connexin45 is downregulated to allow action potentials to spread more readily through the myometrium.     

Photobleaching with phloxine B sensitizer to reduce food matrix interference for detection of Escherichia coli serotype O157:H7 in fresh spinach by flow cytometry

A flow cytometric method (RAPID-B™) with detection sensitivity of one viable cell of Escherichia coli serotype O157:H7 in fresh spinach (Spinacia oleracea) was developed and evaluated. The major impediment to achieving this performance was mistaking autofluorescing spinach particles for tagged target cells. Following a 5 h non-selective enrichment, artificially inoculated samples were photobleached, using phloxine B as a photosensitizer. Samples were centrifuged at high speed to concentrate target cells, then gradient centrifuged to separate them from matrix debris. In external laboratory experiments, RAPID-B and the reference method both correctly detected E. coli O157:H7 at inoculations of ca. 15 cells. In a follow-up study, after 4 cell inoculations of positives and 6 h enrichment, RAPID-B correctly identified 92% of 25 samples. The RAPID-B method limit of detection (LOD) was one cell in 25 g. It proved superior to the reference method (which incorporated real time-PCR, selective enrichment, and culture plating elements) in accuracy and speed.