Calculating thermal radiation hazards in large fires

The author has developed, and discusses here, a method for assessing the thermal radiation hazards to objects from fires. A comparison of the calculations to an actual fire experience seems to indicate that the method is reasonably accurate, though somewhat conservative.     

Stagnation Point Radiative Heat Transfer Measurements at Supersatellite Velocities

Total heat transfer measurements were made using standard calorimeter techniques in an electrically driven 6.5 inch diameter shock tube at stagnation point enthalpies corresponding to velocities of up to 47, 000 ft/sec in air at an altitude of 140,000 feet. The radiative component was separated from the total by subtracting the measured convective component from the total heat transfer rate measurement. The remaining radiative component is compared with the equilibrium radiative heat transfer theory of Kivel and Bailey and the nonequilibrium estimates of Teare, Ge?rgiev, and Allen. The possible sources of error, the advantages and limitations of this technique and the discrepancy with theory is discussed in detail.     

Beitr?ge zur Kenntnis der w?sserigen L?sung der Kohlens?ure

Ohne Zusammenfassung     

Novel Cyclopentaquinoline and Acridine Analogs as Multifunctional,Potent Drug Candidates in Alzheimer’s Disease

A series of new cyclopentaquinoline derivatives with 9-acridinecarboxylic acid and a different alkyl chain length were synthesized, and their ability to inhibit cholinesterases was evaluated. All designed compounds, except derivative 3f, exhibited a selectivity for butyrylcholinesterase (BuChE) with IC₅₀ values ranging from 103 to 539 nM. The 3b derivative revealed the highest inhibitory activity towards BuChE (IC₅₀ = 103.73 nM) and a suitable activity against AChE (IC₅₀ = 272.33 nM). The 3f derivative was the most active compound to AChE (IC₅₀ = 113.34 nM) with satisfactory activity towards BuChE (IC₅₀ = 203.52 nM). The potential hepatotoxic effect was evaluated for both 3b and 3f compounds. The 3b and 3f potential antioxidant activity was measured using the ORAC-FL method. The 3b and 3f derivatives revealed a significantly higher antioxidant potency, respectively 35 and 25 higher than tacrine. Theoretical, physicochemical, and pharmacokinetic properties were calculated using ACD Labs Percepta software. Molecular modeling and kinetic study were used to reveal the mechanism of cholinesterase inhibition in the most potent compounds: 3b and 3f.