Effects of brefeldin-A on Golgi morphology in human cultured fibroblasts observed in three-dimensional stereo scanning electron microscopy

Brefeldin A (BFA) has been reported to cause disassembly of the Golgi. We have used three-dimensional (3-D) high-resolution scanning electron microscopy (HRSEM) to investigate these effects in human skin fibroblast cells. The spontaneous reassembly during prolonged exposure to BFA and some effects of forskolin were observed. A BFA concentration of 5μg/ml caused Golgi complexes to become vesicular, resulting in a progressive decrease in the size of the Golgi. Morphologic changes were visible within 2 min of BFA incubation, and by 30 min no identifiable Golgi could be found. Spontaneous reassembly of the Golgi apparatus upon the removal of the BFA or with continued long-term exposure with BFA could not be confirmed. Preliminary experiments with forskolin were not effective in reversing or inhibiting the effects of BFA in human fibroblast cells grown in culture. This inability for spontaneous reassembly and nonreversal by forskolin may reflect a differential effect of BFA in various cell types. HRSEM has proven to be useful for observing 3-D morphologic effects of BFA in Golgi.     

The physician-delivered smoking intervention project: Can short-term interventions produce long-term effects for a general outpatient population?

Patterns of smoking cessation using 6- and 12-mo follow-up data are reported for 1,261 primary care patients randomized to 3 physician-delivered smoking interventions: advice only (AO), counseling (CI), and counseling plus availability of nicotine-containing gum (CI?+?NCG). One-week point-prevalence cessation rates at 12 mo did not differ among the interventions: AO (15.2%), CI (12.9%) and CI?+?NCG (16.7%). However, maintained cessation rates (abstinent at both 6 and 12 mo) increased with intervention intensity: AO (6.0%), CI (7.8%), and CI?+?NCG (10.0%): Test of trend χ–2?=?5.06, p?=?.02. CI?+?NCG was significantly higher than AO (p?=?.02). The findings support the following conclusions: Brief physician delivered intervention with availability of nicotine-containing gum can have a beneficial long-term effect on smoking cessation, and cohort data as well as point-prevalence rates are important when assessing the long-term impact of lifestyle interventions. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Self-efficacy expectations predict survival for patients with chronic obstructive pulmonary disease.

Evaluated the validity of self-efficacy expectations as predictors of mortality for 119 patients with chronic obstructive pulmonary disease. Ss completed 4 physiological measures that represent common clinical indicators of disease severity: forced expiratory volume in 1 s(FEV1.0), arterial blood gas measurement of resting partial pressure of oxygen (PaO?), single-breath diffusing capacity (DLCO), and maximum oxygen uptake (V02max) during exercise. In addition, self-reported self-efficacy expectation for walking on a treadmill was measured. Self-efficacy was a significant univariate predictor of 5-yr survival. However, when controlling for FEV1.0 in multivariate survival analysis, self-efficacy had only a marginal effect. Simple self-report scales may provide significant information about health status. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Interactions in predicting mood from extraversion and neuroticism.

Many researchers have found evidence that, when only marginal distributions are examined, extraversion is related primarily to positive affect, whereas neuroticism is related primarily to negative affect. Recent findings have suggested that extraversion and neuroticism interact in predicting mood so that marginal relations could be misleading. The present study used extraversion (and its components, sociability and impulsivity) along with neuroticism in regression equations including interactive and curvilinear components to predict measures of positive and negative affect among 384 undergraduates. Results confirm earlier findings that extraversion and neuroticism interact in predicting both positive and negative affect. The interaction pattern was similar to previous findings: Both positive and negative affect were strongly related to extraversion only among neurotic Ss. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

"Does reward increase or decrease creativity?": Correction to Eisenberger and Selbst.

Reports an error in "Does reward increase or decrease creativity" by Robert Eisenberger and Michael Selbst (Journal of Personality and Social Psychology, 1994[Jun], Vol 66[6], 1116-1127). In the aforementioned article, Figures 1 and 2 were interchanged. The figures appear with their correct captions in the erratum. (The following abstract of the original article appeared in record 1994-40652-001.) Two studies involving 504 school children investigated why behaviorists and cognitively oriented investigators have come to opposite conclusions about reward's effects on creativity. A monetary reward for a high degree of divergent thought in 1 task (word construction) increased children's subsequent originality in a different task (picture drawing). The same reward, made contingent on a low degree of divergent thought, reduced this generalized originality. These effects were eliminated by using a large reward and were restored by keeping the large reward out of the children's sight. The results suggest that reward training increases generalized creativity when (1) a high degree of divergent thought is required and (2) the reward is presented in not too salient a fashion. The findings are consistent with a 2-factor interpretation of rewarded creativity effects that incorporates learned industriousness and selective attention. [A correction concerning this article appears in Journal of Personality & Social Psychology, 1994(Jul), Vol 67(1), 125. Figures 1 and 2 were interchanged.] (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Reply to Humphreys: On the compatibility of twelve-step programs and psychotherapy.

Comments on K. Humphreys's (see record 1994-34917-001) article discussing the limitations of integrating psychotherapy and 12-step programs. Humphreys's arguments based on the approaches' purported differences in helping values are not logically demonstrated or empirically determined. Therapists should be trained to deal with spiritual issues and perspectives in a respectful and knowledgeable way. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Similarity, interactive activation, and mapping.

The question of "What makes things seem similar?" is important both for the pivotal role of similarity in theories of cognition and for an intrinsic interest in how people make comparisons. Similarity frequently involves more than listing the features of the things to be compared and comparing the lists for overlap. Often, the parts of one thing must be aligned or placed in correspondence with the parts of the other. The quantitative model with the best overall fit to human data assumes an interactive activation process whereby correspondences between the parts of compared things mutually and concurrently influence each other. An essential aspect of this model is that matching and mismatching features influence similarity more if they belong to parts that are placed in correspondence. In turn, parts are placed in correspondence if they have many features in common and if they are consistent with other developing correspondences. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

The Relevance of Early Lacan for Psychoanalytic Phenomenology and Contextualism: Preliminary Communication.

In this article, the author attempts to show that Lacan's early writings are relevant to the author's own psychoanalytic perspective by virtue of Lacan's view of the psychoanalytic method and process as phenomenological, hermeneutic, and dialogic. (PsycINFO Database Record (c) 2010 APA, all rights reserved)