Thyroid cancer after exposure to external radiation: a pooled analysis of seven studies

The thyroid gland of children is especially vulnerable to the carcinogenic action of ionizing radiation. To provide insights into various modifying influences on risk, seven major studies with organ doses to individual subjects were evaluated. Five cohort studies (atomic bomb survivors, children treated for tinea capitis, two studies of children irradiated for enlarged tonsils, and infants irradiated for an enlarged thymus gland) and two case-control studies (patients with cervical cancer and childhood cancer) were studied. The combined studies include almost 120,000 people (approximately 58,000 exposed to a wide range of doses and 61,000 nonexposed subjects), nearly 700 thyroid cancers and 3,000,000 person years of follow-up. For persons exposed to radiation before age 15 years, linearity best described the dose response, even down to 0.10 Gy. At the highest doses (> 10 Gy), associated with cancer therapy, there appeared to be a decrease or leveling of risk. For childhood exposures, the pooled excess relative risk per Gy (ERR/Gy) was 7.7 (95% CI = 2.1, 28.7) and the excess absolute risk per 10(4) PY Gy (EAR/10(4) PY Gy) was 4.4 (95% CI = 1.9, 10.1). The attributable risk percent (AR%) at 1 Gy was 88%. However, these summary estimates were affected strongly by age at exposure even within this limited age range. The ERR was greater (P = 0.07) for females than males, but the findings from the individual studies were not consistent. The EAR was higher among women, reflecting their higher rate of naturally occurring thyroid cancer. The distribution of ERR over time followed neither a simple multiplicative nor an additive pattern in relation to background occurrence. Only two cases were seen within 5 years of exposure. The ERR began to decline about 30 years after exposure but was still elevated at 40 years. Risk also decreased significantly with increasing age at exposure, with little risk apparent after age 20 years. Based on limited data, there was a suggestion that spreading dose over time (from a few days to > 1 year) may lower risk, possibly due to the opportunity for cellular repair mechanisms to operate. The thyroid gland in children has one of the highest risk coefficients of any organ and is the only tissue with convincing evidence for risk about 1.10 Gy.     

适度集成有助于汽车功率驱动系统设计

汽车电子系统设计人员在选择MOSFET器件时以前只有两种选择:没有任何保护措施的“简单”PowerMOS或具有完全保护的器件,后者在环境条件超出规定范围时会自动关闭,然而带有额外逻辑和保护电路的完全保护器件成本较高。因此,有些供应商开发了一种介于两者之间的适度集成的新型器件,在单芯片中结合了TrenchMOS技术以及温度和电流传感元件。其优点是不需要昂贵的智能功率器件即可为系统提供保护并节约空间。     

Space-dependent color gamut mapping: a variational approach.

Gamut mapping deals with the need to adjust a color image to fit into the constrained color gamut of a given rendering medium. A typical use for this tool is the reproduction of a color image prior to its printing, such that it exploits best the given printer/medium color gamut, namely the colors the printer can produce on the given medium. Most of the classical gamut mapping methods involve a pixel-by-pixel mapping and ignore the spatial color configuration. Recently proposed spatial-dependent approaches for gamut mapping are either based on heuristic assumptions or involve a high computational cost. In this paper, we present a new variational approach for space-dependent gamut mapping. Our treatment starts with the presentation of a new measure for the problem, closely related to a recent measure proposed for Retinex. We also link our method to recent measures that attempt to couple spectral and spatial perceptual measures. It is shown that the gamut mapping problem leads to a quadratic programming formulation, guaranteed to have a unique solution if the gamut of the target device is convex. An efficient numerical solution is proposed with promising results.     

The DTX-240D digital circuit multiplication system

This paper describes the DTX-240D digital circuit multiplication system (DCMS) offered by ECI Telecom. It will accept up to 240 × 64 kb/s trunks carrying either 64 kb/s voice, voice band analogue non-speech signals, or digital data for transmission over a 2·048 Mb/s digital link. Over 1000 are currently ‘on-line’ and carrying traffic. The system comprises a pair of terminals, one on each side of the interterminal digital link (bearer). It will normally operate in the network at a concentration ratio of 5:1, in which case 150 × 64 kb/s trunks, carrying voice, voice band data or digital data can be concentrated into one 2·048 Mb/s bearer. The users are able to increase the number of trunks up to 240 per 2·048 Mb/s bearer, when time zone differences cause a spread of busy-hour traffic carried on a single system. Each terminal will normally be located at an international switching centre (ISC) but may also be located at an earth-station. The system uses a DSI (digital speech interpolation) stage providing a 2·5:1 multiplication, followed by an additional 2:1 multiplication by means of ADPCM (adaptive differential pulse code modulation). In addition, the VBR (variable bit rate) technique is used to prevent clipping, due to overload congestion. The system can also be used with 1·544 Mb/s digital bit streams (trunk side or bearer).     

Mobile Commerce: Framework,Applications and Networking Support

Advances in e-commerce have resulted in significant progress towards strategies, requirements, and development of e-commerce applications. However, nearly all e-commerce applications envisioned and developed so far assume fixed or stationary users with wired infrastructure. We envision many new e-commerce applications that will be possible and significantly benefit from emerging wireless and mobile networks. To allow designers, developers, and researchers to strategize and create mobile commerce applications, we propose a four-level integrated framework for mobile commerce. Since there are potentially an unlimited number of mobile commerce applications, we attempt to identify several important classes of applications such as mobile financial applications, mobile inventory management, proactive service management, product location and search, and wireless re-engineering. We discuss how to successfully define, architect, and implement the necessary hardware/software infrastructure in support of mobile commerce. Also, to make mobile commerce applications a reality, we address networking requirements, discuss support from wireless carriers, and present some open research problems.     

Toward an acoustic noninvasive diagnosis of urinary bladder outlet obstruction

On average, in aging males, the prostate enlarges (benign prostatic enlargement or BPE) and may cause bladder outlet obstruction (BOO). The internationally standardized method for diagnosing BOO is based on measurements of urinary flow rate and bladder pressure, using a catheter inserted into the bladder via the urethra. This method is invasive, time-consuming, and uncomfortable for the patient. We are developing a novel diagnostic method based on perineal recording of sound during urinary flow. Although it is known that (some aspects of) the recorded sound are (among others) related to the degree of obstruction, an exact and unique relation allowing derivation of the degree of obstruction from the sound recording is not known. In a biophysical model of the urethra, we found that the weighted average frequency, the standard deviation, and the skewness of the power spectrum are monotonically related to the degree of obstruction. The standard deviation was the most significant predictor of BOO (89% correct). Based on this model study, we are confident that a simple noninvasive acoustic method for diagnosing BOO caused by BPE can be developed. This would lower the threshold for urodynamic testing of patients with lower urinary tract symptoms resulting in higher therapeutic efficacy.     

Forgetting all else: On the antecedents and consequences of goal shielding.

Six studies explore the role of goal shielding in self-regulation by examining how activation of focal goals to which the individual is committed inhibits the accessibility of alternative goals. Consistent evidence was found for such goal shielding, and a number of its moderators were identified: Individuals' level of commitment to the focal goal, their degree of anxiety and depression, their need for cognitive closure, and differences in their goal-related tenacity. Moreover, inhibition of alternative goals was found to be more pronounced when they serve the same overarching purpose as the focal goal, but lessened when the alternative goals facilitate focal goal attainment. Finally, goal shielding was shown to have beneficial consequences for goal pursuit and attainment. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Influence of agronomic management of legume crops on soil accumulation with nitrate

Nitrate is known to accumulate under legume crops. The effects of legume crop, inoculation, row width, sowing rate, sowing date, and intra-cropping with wheat, on the amount and soil distribution of mineral N, residual soil water, crop biomass and crop N were studied at Wagga Wagga in south-east Australia. After removal of most of the above-ground plant material, the treatment effects on the biomass, N content, grain yield and grain N of wheat, established in the following season, were also measured. In a later experiment at Wagga, the recovery of 15N applied to the mid-row of lupin crops established at three row widths was estimated at crop maturity. At Condobolin, row width effects on the soil distribution of mineral N, biomass, N accumulation and N fixation of crop legumes and cereals, were determined. At physiological maturity, at Wagga Wagga, very little nitrate was left beneath cereals. Significantly more was left under legume crops, mostly below 30 cm of soil depth, and it was distributed differently depending on crop, inoculation, and sampling location. More nitrate was left under pea and faba than under lupin, and in response to inoculation. Mixing wheat with narrow-leaf lupin did not prevent nitrate accumulation in soil. For most of the legumes more nitrate was left in the mid-row than in the in-row; and more nitrate was left at the mid-row of lupin crops sown with wider rows. The additional nitrate left with wider rows increased the growth, N content, grain yield and protein of wheat established in the following season. 15N labelled nitrate applied mid-row was used less effectively by lupin as row width increased, in a dry season. At Condobolin, lupin established with wide rows used less soil nitrate than with narrower rows but maintained crop N by increased N fixation. In contrast, field pea maintained N demand by increasing nitrate uptake at intermediate row spacing. The study shows that the amount of nitrate accumulated in soil during legume cropping is susceptible to agronomic management, particularly crop selection, row width and inoculation; and that variation in the amount of this nitrate may carry forward to impact wheat production in the follow-on season.