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101.
Raz’s parallel repetition theorem (SIAM J Comput 27(3):763–803, 1998) together with improvements of Holenstein (STOC, pp 411–419, 2007) shows that for any two-prover one-round game with value at most ${1- \epsilon}$ 1 - ? (for ${\epsilon \leq 1/2}$ ? ≤ 1 / 2 ), the value of the game repeated n times in parallel on independent inputs is at most ${(1- \epsilon)^{\Omega(\frac{\epsilon^2 n}{\ell})}}$ ( 1 - ? ) Ω ( ? 2 n ? ) , where ? is the answer length of the game. For free games (which are games in which the inputs to the two players are uniform and independent), the constant 2 can be replaced with 1 by a result of Barak et al. (APPROX-RANDOM, pp 352–365, 2009). Consequently, ${n=O(\frac{t \ell}{\epsilon})}$ n = O ( t ? ? ) repetitions suffice to reduce the value of a free game from ${1- \epsilon}$ 1 - ? to ${(1- \epsilon)^t}$ ( 1 - ? ) t , and denoting the input length of the game by m, it follows that ${nm=O(\frac{t \ell m}{\epsilon})}$ n m = O ( t ? m ? ) random bits can be used to prepare n independent inputs for the parallel repetition game. In this paper, we prove a derandomized version of the parallel repetition theorem for free games and show that O(t(m?)) random bits can be used to generate correlated inputs, such that the value of the parallel repetition game on these inputs has the same behavior. That is, it is possible to reduce the value from ${1- \epsilon}$ 1 - ? to ${(1- \epsilon)^t}$ ( 1 - ? ) t while only multiplying the randomness complexity by O(t) when m = O(?). Our technique uses strong extractors to “derandomize” a lemma of Raz and can be also used to derandomize a parallel repetition theorem of Parnafes et al. (STOC, pp 363–372, 1997) for communication games in the special case that the game is free.  相似文献   
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The guest editors introduce this special issue showcasing Micro's Top Picks from the Microarchitecture Conferences of 2006. They describe the issue's intensive submission and selection process. The articles focus on the design of resilient computing systems, the architecture of multicore systems, performance evaluation techniques, general-purpose processors, and a programmable architecture for wireless protocols.  相似文献   
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Nerve growth factor (NGF) plays a vital role in reducing the loss of cholinergic neurons in Alzheimer's disease (AD). However, its delivery to the brain remains a challenge. Herein, NGF is loaded into degradable oxidized porous silicon (PSiO2) carriers, which are designed to carry and continuously release the protein over a 1 month period. The released NGF exhibits a substantial neuroprotective effect in differentiated rat pheochromocytoma PC12 cells against amyloid‐beta (Aβ)‐induced cytotoxicity, which is associated with Alzheimer's disease. Next, two potential localized administration routes of the porous carriers into murine brain are investigated: implantation of PSiO2 chips above the dura mater, and biolistic bombardment of PSiO2 microparticles through an opening in the skull using a pneumatic gene gun. The PSiO2‐implanted mice are monitored for a period of 8 weeks and no inflammation or adverse effects are observed. Subsequently, a successful biolistic delivery of these highly porous microparticles into a live‐mouse brain is demonstrated for the first time. The bombarded microparticles are observed to penetrate the brain and reach a depth of 150 µm. These results pave the way for using degradable PSiO2 carriers as potential localized delivery systems for NGF to the brain.  相似文献   
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Coronavirus disease-19 (COVID-19) patients are prone to thrombotic complications that may increase morbidity and mortality. These complications are thought to be driven by endothelial activation and tissue damage promoted by the systemic hyperinflammation associated with COVID-19. However, the exact mechanisms contributing to these complications are still unknown. To identify additional mechanisms contributing to the aberrant clotting observed in COVID-19 patients, we analyzed platelets from COVID-19 patients compared to those from controls using mass spectrometry. We identified increased serum amyloid A (SAA) levels, an acute-phase protein, on COVID-19 patients’ platelets. In addition, using an in vitro adhesion assay, we showed that healthy platelets adhered more strongly to wells coated with COVID-19 patient serum than to wells coated with control serum. Furthermore, inhibitors of integrin aIIbβ3 receptors, a mediator of platelet–SAA binding, reduced platelet adhesion to recombinant SAA and to wells coated with COVID-19 patient serum. Our results suggest that SAA may contribute to the increased platelet adhesion observed in serum from COVID-19 patients. Thus, reducing SAA levels by decreasing inflammation or inhibiting SAA platelet-binding activity might be a valid approach to abrogate COVID-19-associated thrombotic complications.  相似文献   
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The left atrial appendage (LAA) of the adult heart has been shown to contain cardiac and myeloid progenitor cells. The resident myeloid progenitor population expresses an array of pro-regenerative paracrine factors. Cardiac constructs have been shown to inhibit deleterious remodeling of the heart using physical support. Due to these aspects, LAA holds promise as a regenerative transplant. LAAs from adult mT/mG mice were transplanted to the recipient 129X1-SvJ mice simultaneously as myocardial infarction (MI) was performed. A decellularized LAA patch was implanted in the control group. Two weeks after MI, the LAA patch had integrated to the ventricular wall, and migrated cells were seen in the MI area. The cells had two main phenotypes: small F4/80+ cells and large troponin C+ cells. After follow-up at 8 weeks, the LAA patch remained viable, and the functional status of the heart improved. Cardiac echo demonstrated that, after 6 weeks, the mice in the LAA-patch-treated group showed an increasing and statistically significant improvement in cardiac performance when compared to the MI and MI + decellularized patch controls. Physical patch-support (LAA and decellularized LAA patch) had an equal effect on the inhibition of deleterious remodeling, but only the LAA patch inhibited the hypertrophic response. Our study demonstrates that the LAA transplantation has the potential for use as a treatment for myocardial infarction. This method can putatively combine cell therapy (regenerative effect) and physical support (inhibition of deleterious remodeling).  相似文献   
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Transition metal dichalcogenides (TMDCs) based materials are considered as highly active alternatives to the precious Pt-based catalysts for the hydrogen evolution reaction (HER). In particular, MoSeemerges as a promising catalyst due to its abundance and electrochemical stability, but further modifications are still required to enhance its performance, specifically in alkaline conditions. Here, we developed a method to obtain MoSewith two cobalt doping patterns: homogeneously doped and edge doped nanoflowers, with abundant edge sites and extended surface area. The results show that low concentration of doping enhances the catalytic activity toward HER. Incorporation of cobalt as a substituent dopant within the layered structure of MoSeappears to have two major contributions: it changes the chemical environment providing more active sites with favored hydrogen adsorption properties, and improves the charge transfer resistance and thus facilitates the HER kinetics. Moreover, the homogeneous and edge-doped nanoflowers show different pH-dependence of HER activity. Edge-doped samples exhibit significantly improved performance in acidic medium, while the overpotential increases in alkaline environment upon doping. A mechanistic explanation of the observed effect is proposed. This work opens up an additional path for improving the catalytic activity of TMDCs in acidic or alkaline medium using a simple and facile method with only small quantities of dopants.  相似文献   
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