滚动轴承外圈多点故障特征分析

滚动轴承发生多点故障时会产生复杂的振动特征,影响轴承故障诊断的准确性。针对滚动轴承外圈多点故障诊断特征的变化规律,考虑滚动轴承外圈故障数量、故障间隔和载荷分布对故障特征的影响,采用五自由度动力学模型进行仿真分析。通过龙格库塔法对动力学方程进行数值求解,分析了滚动轴承外圈单点故障和多点故障的诊断特征。结果表明:当外圈具有多点故障时,随着故障数量和故障间隔的变化,故障特征频率各谐波的幅值会发生变化;当多点故障满足载荷相等和一定的间隔关系时,故障特征频率值与故障数量之间呈现对应的倍数关系。通过滚动轴承多点故障模拟试验验证了结论的正确性。     

A Novel L-Phenylalanine Dipeptide Inhibits the Growth and Metastasis of Prostate Cancer Cells via Targeting DUSP1 and TNFSF9

Prostate cancer (PCa) is a common malignant cancer of the urinary system. Drug therapy, chemotherapy, and radical prostatectomy are the primary treatment methods, but drug resistance and postoperative recurrence often occur. Therefore, seeking novel anti-tumor compounds with high efficiency and low toxicity from natural products can produce a new tumor treatment method. Matijin-Su [N-(N-benzoyl-L-phenylalanyl)-O-acetyl-L-phenylalanol, MTS] is a phenylalanine dipeptide monomer compound that is isolated from the Chinese ethnic medicine Matijin (Dichondra repens Forst.). Its derivatives exhibit various pharmacological activities, especially anti-tumor. Among them, the novel MTS derivative HXL131 has a significant inhibitory effect against prostate tumor growth and metastasis. This study is designed to investigate the effects of HXL131 on the growth and metastasis of human PCa cell lines PC3 and its molecular mechanism through in vitro experiments combined with proteomics, molecular docking, and gene silencing. The in vitro results showed that HXL131 concentration dependently inhibited PC3 cell proliferation, induced apoptosis, arrested cell cycle at the G2/M phase, and inhibited cell migration capacity. A proteomic analysis and a Western blot showed that HXL131 up-regulated the expression of proliferation, apoptosis, cell cycle, and migration-related proteins CYR61, TIMP1, SOD2, IL6, SERPINE2, DUSP1, TNFSF9, OSMR, TNFRSF10D, and TNFRSF12A. Molecular docking, a cellular thermal shift assay (CETSA), and gene silencing showed that HXL131 had a strong binding affinity with DUSP1 and TNFSF9, which are important target genes for inhibiting the growth and metastasis of PC3 cells. This study demonstrates that HXL131 exhibited excellent anti-prostate cancer activity and inhibited the growth and metastasis of prostate cancer cells by regulating the expression of DUSP1 and TNFSF9.     

Cytogenetic and Molecular Marker Analyses of a Novel Wheat–Psathyrostachys huashanica 7Ns Disomic Addition Line with Powdery Mildew Resistance

Powdery mildew caused by Blumeria graminis f. sp. tritici is a devastating disease that reduces wheat yield and quality worldwide. The exploration and utilization of new resistance genes from wild wheat relatives is the most effective strategy against this disease. Psathyrostachys huashanica Keng f. ex P. C. Kuo (2n = 2x = 14, NsNs) is an important tertiary gene donor with multiple valuable traits for wheat genetic improvement, especially disease resistance. In this study, we developed and identified a new wheat—P. huashanica disomic addition line, 18-1-5—derived from a cross between P. huashanica and common wheat lines Chinese Spring and CSph2b. Sequential genomic and multicolor fluorescence in situ hybridization analyses revealed that 18-1-5 harbored 21 pairs of wheat chromosomes plus a pair of alien Ns chromosomes. Non-denaturing fluorescence in situ hybridization and molecular marker analyses further demonstrated that the alien chromosomes were derived from chromosome 7Ns of P. huashanica. The assessment of powdery mildew response revealed that line 18-1-5 was highly resistant at the adult stage to powdery mildew pathogens prevalent in China. The evaluation of agronomic traits indicated that 18-1-5 had a significantly reduced plant height and an increased kernel length compared with its wheat parents. Using genotyping-by-sequencing technology, we developed 118 PCR-based markers specifically for chromosome 7Ns of P. huashanica and found that 26 of these markers could be used to distinguish the genomes of P. huashanica and other wheat-related species. Line 18-1-5 can therefore serve as a promising bridging parent for wheat disease resistance breeding. These markers should be conducive for the rapid, precise detection of P. huashanica chromosomes and chromosomal segments carrying Pm resistance gene(s) during marker-assisted breeding and for the investigation of genetic differences and phylogenetic relationships among diverse Ns genomes and other closely related ones.     

复合4邻域圈提取CNN的鲁棒性设计

细胞神经网络（Cellular Neural Network,CNN）于1988年由L.O.Chua 等人提出,已经成为一种处理图像和视频信号、机器人技术、生物视觉、高级大脑功能的新工具。细胞神经网络模板的鲁棒性设计是CNN在实际应用中碰到的重要课题之一。目的是设计一种能够提取复合4邻域圈的CNN,并对其模板进行鲁棒性设计,给出满足相应功能CNN的鲁棒性定理。该定理提供了能达到预先指定的图像处理功能的CNN模板参数不等式。数值模拟例子说明了理论证明的有效性。     

基于统计的中文地名自动识别研究

中文地名的自动识别是命名实体识别任务中难度较大的任务之一,目的是从中文文本中自动准确提取地理专用名词.文中使用统计模型中的条件随机场对中文地名的自动识别在字一级粒度进行了研究.在研究中利用条件随机场能任意添加特征的优点,合理引用了丰富的特征组合,在大规模语料上进行训练,统计获得标注序列基于特征集的条件概率分布,并采用序列标注的方式,实现中文地名的自动识别.多次闭合测试和开放测试结果F1值为90％左右,识别效果良好.     

耐热ABS树脂的制备

采用乳液聚合法合成了一系列N-苯基马来酰亚胺（NPMI）-苯乙烯（St）-丙烯腈（AN）共聚物（简称SMIA树脂）,将其与AN-丁二烯-St三元共聚物（ABS）熔融共混制备了耐热ABS树脂。采用傅里叶变换红外光谱、差示扫描量热法对SMIA树脂进行了表征,探讨了SMIA树脂组成对ABS树脂性能的影响。结果发现：NPMI的引入可以显著提高ABS树脂的耐热性能,当w（NPMI）为10％～20％、m（St）／m（AN）为70：30时,ABS树脂既具有较高的玻璃化转变温度,又具有较好的力学性能。     

Highly Stretchable and Sensitive Flexible Strain Sensor Based on Fe NWs/Graphene/PEDOT:PSS with a Porous Structure

With the rapid development of wearable smart electronic products, high-performance wearable flexible strain sensors are urgently needed. In this paper, a flexible strain sensor device with Fe NWs/Graphene/PEDOT:PSS material added under a porous structure was designed and prepared. The effects of adding different sensing materials and a different number of dips with PEDOT:PSS on the device performance were investigated. The experiments show that the flexible strain sensor obtained by using Fe NWs, graphene, and PEDOT:PSS composite is dipped in polyurethane foam once and vacuum dried in turn with a local linearity of 98.8%, and the device was stable up to 3500 times at 80% strain. The high linearity and good stability are based on the three-dimensional network structure of polyurethane foam, combined with the excellent electrical conductivity of Fe NWs, the bridging and passivation effects of graphene, and the stabilization effect of PEDOT:PSS, which force the graphene-coated Fe NWs to adhere to the porous skeleton under the action of PEDOT:PSS to form a stable three-dimensional conductive network. Flexible strain sensor devices can be applied to smart robots and other fields and show broad application prospects in intelligent wearable devices.     

含多裂纹结构的断裂可靠性分析

基于随机有限元法和可靠性设计理论,建立了一种含多裂纹结构的断裂可靠性分析模型。首先,根据最小二乘法则建立应力强度因子的表达式,然后将影响结构断裂的不确定因素视为随机变量,通过一阶二次矩法和随机有限元法求出每条裂纹的可靠度指标,最后将含多裂纹结构看作一个由所有裂纹组成的串联系统,求出各裂纹之间的相关系数,并得出多裂纹结构失效概率的Ditlevsen界限值。数值算例表明,本方法具有较强的适用性。     

异构本体集成中基于视图的映射方法

对现有本体映射方法进行比较和分析后,提出了一种基于视图的映射方法。本体视图实际上是对本体的抽取,即本体的一种应用模式。作为对用户知识的反映它不仅增加了本体映射的可理解性和清晰性,同时也简化了用户对信息的检索。通过构造本体视图间的双向映射关系,既保证了信息查找和定位准确、高效,又提高了映射关系的可扩展性,使本体映射更适合动态变化的信息环境。     

从SCHEMA到关系的映射

文章对SCHEMA描述的XML文档的数据模型进行了集合分析,并在其描述的集合上定义了关联依赖关系、值依赖关系和两种取值关系,根据这些关系及SCHEMA规范所规定的约束,建立了一组从SCHEMA到关系型数据库的映射规则,并且证明由此规则得到的映射是完备的,而且映射后的关系符合第三范式。文章最后提出了可进一步研究的问题和方向。