Ruslan Shaydulin  Hayato Ushijima‐Mwesigwa  Ilya Safro  Susan Mniszewski  Yuri Alexeev 《Advanced Quantum Technologies》2019,2(9)

In recent years, a number of quantum computing devices with small numbers of qubits have become available. A hybrid quantum local search (QLS) approach that combines a classical machine and a small quantum device to solve problems of practical size is presented. The proposed approach is applied to the network community detection problem. QLS is hardware‐agnostic and easily extendable to new quantum computing devices as they become available. It is demonstrated to solve the 2‐community detection problem on graphs of sizes of up to 410 vertices using the 16‐qubit IBM quantum computer and D‐Wave 2000Q, and compare their performance with the optimal solutions. The results herein demonstrate that QLS performs similarly in terms of quality of the solution and the number of iterations to convergence on both types of quantum computers and it is capable of achieving results comparable to state‐of‐the‐art solvers in terms of quality of the solution including reaching the optimal solutions.  相似文献   

    

Viacheslav A. Yanovsky  Mikhail O. Andropov  Regina S. Fakhrislamova  Ruslan A. Churkin  Konstantin M. Minaev  Elena A. Yanovskaya 《Journal of surfactants and detergents》2019,22(3):641-654

The effects of the duration of direct amidation of fatty acids (FA) with diethanolamine on the composition of the products obtained, their surface-active properties, and ability to stabilize water-in-oil emulsions are studied using the example of tall oil distillate. A certain range of synthesis time that corresponds to the maximum content of diethanolamides in the reaction products, and, as a consequence, the highest surface-active and emulsifying properties of the products is shown to exist. An increase in the synthesis duration time leads to a deterioration of these properties due to accumulation of the products of secondary reactions. A new mechanism of the amidation process that includes secondary transformations of diethanolamine and its condensation products with FA into 1,4-bis(2-hydroxyethyl)piperazine derivatives is proposed. The structures of by-products are confirmed using high-performance liquid chromatography-mass spectrometry (HPLC–MS), infrared (IR), and nuclear magnetic resonance (NMR) spectroscopy methods. It is concluded that the acid value of the product as well as the amount of water released during the synthesis cannot serve as a reliable criterion for completion of the process.  相似文献   

    

Dmitry Tolmachev  Natalia Lukasheva  Ruslan Ramazanov  Victor Nazarychev  Natalia Borzdun  Igor Volgin  Maria Andreeva  Artyom Glova  Sofia Melnikova  Alexey Dobrovskiy  Steven A. Silber  Sergey Larin  Rafael Maglia de Souza  Mauro Carlos Costa Ribeiro  Sergey Lyulin  Mikko Karttunen 《International journal of molecular sciences》2022,23(2)

Deep eutectic solvents (DESs) are one of the most rapidly evolving types of solvents, appearing in a broad range of applications, such as nanotechnology, electrochemistry, biomass transformation, pharmaceuticals, membrane technology, biocomposite development, modern 3D-printing, and many others. The range of their applicability continues to expand, which demands the development of new DESs with improved properties. To do so requires an understanding of the fundamental relationship between the structure and properties of DESs. Computer simulation and machine learning techniques provide a fruitful approach as they can predict and reveal physical mechanisms and readily be linked to experiments. This review is devoted to the computational research of DESs and describes technical features of DES simulations and the corresponding perspectives on various DES applications. The aim is to demonstrate the current frontiers of computational research of DESs and discuss future perspectives.  相似文献   

    

Olga A. Namakanova  Ekaterina A. Gorshkova  Ruslan V. Zvartsev  Sergei A. Nedospasov  Marina S. Drutskaya  Ekaterina O. Gubernatorova 《International journal of molecular sciences》2022,23(7)

Combined anti-cytokine therapy is a promising therapeutic approach for uncontrolled steroid-resistant asthma. In this regard, simultaneous blockade of IL-4 and IL-13 signaling by Dupilumab (anti-IL-4Ra monoclonal antibody) was recently approved for severe eosinophilic asthma. However, no therapeutic options for neutrophilic asthma are currently available. Recent advances in our understanding of asthma pathogenesis suggest that both IL-6 and TNF may represent potential targets for treatment of severe neutrophilic asthma. Nevertheless, the efficacy of simultaneous pharmacological inhibition of TNF and IL-6 in asthma was not yet studied. To evaluate the potency of combined cytokine inhibition, we simultaneously administrated IL-6 and TNF inhibitors to BALB/c mice with HDM-induced asthma. Combined IL-6/TNF inhibition, but not individual blockade of these two cytokines, led to complex anti-inflammatory effects including reduced Th2-induced eosinophilia and less prominent Th17/Th1-mediated neutrophilic infiltrate in the airways. Taken together, our results provide evidence for therapeutic potential of combined IL-6/TNF inhibition in severe steroid-resistant asthma.  相似文献   

    

Mars G. Sharapov  Ruslan G. Goncharov  Svetlana B. Parfenyuk  Olga V. Glushkova  Vladimir I. Novoselov 《International journal of molecular sciences》2022,23(23)

Peroxiredoxin 6 (Prdx6) is a multifunctional eukaryotic antioxidant enzyme. Mammalian Prdx6 possesses peroxidase activity against a wide range of organic and inorganic hydroperoxides, as well as exhibits phospholipase A2 (aiPLA2) activity, which plays an important role in the reduction of oxidized phospholipids and cell membrane remodeling. Exogenous Prdx6 has recently been shown to be able to penetrate inside the cell. We hypothesized that this entry may be due to the phospholipase activity of Prdx6. Experiments using exogenous Prdx6 in three cell lines (3T3, A549, RAW 264.7) demonstrated that it is the phospholipase activity that promotes its penetration into the cell. Overoxidation of Prdx6 led to a suppression of the peroxidase activity and a 3-to-4-fold growth of aiPLA2, which enhanced the efficiency of its transmembrane transport into the cells by up to 15 times. A mutant form of Prdx6-S32A with an inactivated phospholipase center turned out to be unable to enter the cells in both the reduced and oxidized state of the peroxidase active center. Previously, we have shown that exogenous Prdx6 has a significant radioprotective action. However, the role of phospholipase activity in the radioprotective effects of Prdx6 remained unstudied. Trials with the mutant Prdx6-S32A form, with the use of a total irradiation model in mice, showed a nearly 50% reduction of the radioprotective effect upon aiPLA2 loss. Such a significant decrease in the radioprotective action may be due to the inability of Prdx6-S32A to penetrate animal cells, which prevents its reduction by the natural intracellular reducing agent glutathione S-transferase (πGST) and lowers the efficiency of elimination of peroxides formed from the effect of ionizing radiation. Thus, phospholipase activity may play an important role in the reduction of oxidized Prdx6 and manifestation of its antioxidant properties.  相似文献   

    

Yixuan Ma  Sina Sender  Anett Sekora  Weibo Kong  Peter Bauer  Najim Ameziane  Ruslan Al-Ali  Susann Krake  Mandy Radefeldt  Frank Ulrich Weiss  Markus M. Lerch  Alisha Parveen  Dietmar Zechner  Christian Junghanss  Hugo Murua Escobar 《International journal of molecular sciences》2022,23(8)

The aberrant activation of the phosphoinositide 3-kinase (PI3K)/ protein kinase B (AKT) pathway is common in pancreatic ductal adenocarcinomas (PDAC). The application of inhibitors against PI3K and AKT has been considered as a therapeutic option. We investigated PDAC cell lines exposed to increasing concentrations of MK-2206 (an AKT1/2/3 inhibitor) and Buparlisib (a pan-PI3K inhibitor). Cell proliferation, metabolic activity, biomass, and apoptosis/necrosis were evaluated. Further, whole-exome sequencing (WES) and RNA sequencing (RNA-seq) were performed to analyze the recurrent aberrations and expression profiles of the inhibitor target genes and the genes frequently mutated in PDAC (Kirsten rat sarcoma virus (KRAS), Tumor protein p53 (TP53)). MK-2206 and Buparlisib demonstrated pronounced cytotoxic effects and limited cell-line-specific effects in cell death induction. WES revealed two sequence variants within the direct target genes (PIK3CA c.1143C > G in Colo357 and PIK3CD c.2480C > G in Capan-1), but a direct link to the Buparlisib response was not observed. RNA-seq demonstrated that the expression level of the inhibitor target genes did not affect the efficacy of the corresponding inhibitors. Moreover, increased resistance to MK-2206 was observed in the analyzed cell lines carrying a KRAS variant. Further, increased resistance to both inhibitors was observed in SU.86.86 carrying two TP53 missense variants. Additionally, the presence of the PIK3CA c.1143C > G in KRAS-variant-carrying cell lines was observed to correlate with increased sensitivity to Buparlisib. In conclusion, the present study reveals the distinct antitumor effects of PI3K/AKT pathway inhibitors against PDAC cell lines. Aberrations in specific target genes, as well as KRAS and TP53, individually or together, affect the efficacy of the two PI3K/AKT pathway inhibitors.  相似文献   

Structure and Mechanical Behavior of Al–Nb Hybrids Obtained by High-Pressure-Torsion-Induced Diffusion Bonding and Subsequent Annealing     

Galiia Korznikova  Elena Korznikova  Konstantin Nazarov  Ruslan Shayakhmetov  Rinat Khisamov  Gulnara Khalikova  Radik Mulyukov 《Advanced Engineering Materials》2021,23(1):2000757

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Farid Z. Utyashev  Yan E. Beygelzimer  Ruslan Z. Valiev 《Advanced Engineering Materials》2021,23(7):2100110

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Alexey Mikhaylov  Alexey Belov  Dmitry Korolev  Ivan Antonov  Valentina Kotomina  Alina Kotina  Evgeny Gryaznov  Alexander Sharapov  Maria Koryazhkina  Ruslan Kryukov  Sergey Zubkov  Artem Sushkov  Dmitry Pavlov  Stanislav Tikhov  Oleg Morozov  David Tetelbaum 《Advanced Materials Technologies》2020,5(1)

Variability of resistive switching is a key problem for application of memristive devices in emerging information‐computing systems. Achieving a stable switching between the nonlinear resistive states is an important task on the way to implementation of large memristive cross‐bar arrays and solving the related sneak‐path‐current problem. A promising approach is the fabrication of memristive structures with appropriate interfaces by combining the materials of electrodes with certain oxygen affinity and different dielectric layers. In the present work, such approach allows the demonstration of stabilized resistive switching in a multilayer device structure based on ZrO₂(Y) and Ta₂O₅ films. It is established for the large‐area devices that the switching is stabilized after several hundreds of cycles. A possible scenario of the stabilization is proposed taking into account experimental data on the presence of grain boundaries in ZrO₂(Y) as the preferred sites for nucleation of filaments, self‐organization of Ta nanocrystals as the electric field concentrators in Ta₂O₅ film, as well as oxygen exchange between oxide layers and interface with bottom TiN electrode. The robust resistive switching between nonlinear states is implemented in microscale cross‐point devices without numerous cycling before stabilization promising for the fabrication of programmable memristive weights in passively integrated cross‐bar arrays.  相似文献   

    

Ruslan Z. Valiev  Vil U. Kazykhanov  Aydar M. Mavlyutov  Anna A. Yudakhina  Nguyen Q. Chinh  Maxim Yu Murashkin 《Advanced Engineering Materials》2020,22(1)

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