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101.
Research efforts were given towards development of low carbon high strength steels since recent past. The present study deals with the development of a low carbon high strength steel alloyed with Mn, Ni, Mo, Cu and microalloyed with Ti and Nb. The steel was subjected to three stage controlled rolling operation followed by accelerated cooling. The structure and properties of the steel at various processing conditions were evaluated. Microstructural observation reveals predominantly lath martensite along with twinned martensite structure at all processing conditions. High strength values at higher finish rolling temperatures have been obtained due to fine martensitic structure along with tiny precipitates of microalloying carbide and carbonitride. The strength value increases marginally at lower finishing temperature due to comparatively finer lath size of martensite and increased precipitation density of carbides, carbonitrides along with Cu particles. The variation in impact toughness properties at different finish rolling temperatures is found to be negligible at ambient and subambient temperatures. The formation of stable and large TiN/TiCN particles during casting have impaired the impact toughness values at ambient and at ‐40°C temperatures. 相似文献
102.
Syed Suhaib Deepak Mathaikutty Sandeep Shukla David Berner Jean-Pierre Talpin 《Electronic Notes in Theoretical Computer Science》2006,146(2):169
Latency insensitive protocols (LIPs) have been proposed as a viable means to connect synchronous IP blocks via long interconnects in a system-on-chip. The reason why one needs to implement LIPs on long interconnects stems from the fact that with increasing clock frequencies, the signal delay on some interconnects exceeds the clock period. Correctness of a system composed of synchronous blocks communicating via LIPs is established by showing latency equivalence between a completely synchronous composition of the blocks, and the LIP based composition. A design flow based on a synchronous composition specification, and stepwise refinement to LIP composition can be easily conceived, and a proof obligation to show latency equivalence between the synchronous specification and the refinement needs to be discharged. In this work, we propose a functional programming based framework for modeling and simulating LIP, and implement the semantics of various refinement steps in the programming model, so we can validate the LIP model against the original system within this functional programming framework. Such validation becomes easier due to the inherent denotational model of functional languages. We specifically use Standard ML to model the original system implementation as well as its latency insensitive version and compare the two by creating a model that contains both, giving them the same inputs and checking their outputs to be latency equivalent. 相似文献
103.
Shyam S. Shukla Alka S. Shukla Kwun-Chi Lee
Tejraj M. Aminabhavi
Ramachandra H. Balundgi 《Journal of hazardous materials》1992,30(3):317-331Solidification/stabilization of toxic pentachlorophenol (PCP) has been studied by using spectroscopic and electrochemical techniques. Portland type I c 相似文献
104.
Organs used for transplantation undergo varying degrees of cold ischemia and reperfusion injury after transplantation. In renal transplantation, prolonged cold ischemia is strongly associated with delayed graft function, an event that contributes to inferior graft survival. At present, the pathophysiological changes associated with ischemia/reperfusion injury in clinical renal transplantation are poorly understood. We have performed an immunohistochemical analysis of pre- and postreperfusion biopsies obtained from cadaver (n = 55) and living/related donor (LRD) (n = 11) renal allografts using antibodies to adhesion molecules and leukocyte markers to investigate the intragraft changes after cold preservation and reperfusion. Neutrophil infiltration and P-selectin expression were detected after reperfusion in 29 of 55 (53%) and 24 of 55 (44%) cadaver renal allografts, respectively. In marked contrast, neutrophil infiltration was not observed in LRD allografts, and only 1 of 11 (9%) had an increased level of P-selectin after reperfusion. Immunofluorescent double-staining demonstrated that P-selectin expression resulted from platelet deposition and not from endothelial activation. No statistically significant association was observed between neutrophil infiltration and P-selectin expression in the glomeruli or intertubular capillaries despite the large number of cadaver renal allografts with postreperfusion changes. Neutrophil infiltration into the glomeruli was significantly associated with long cold ischemia times and delayed graft function. Elevated serum creatinine levels at 3 and 6 months after transplantation were also associated with the presence of neutrophils and platelets after reperfusion. Our results suggest that graft function may be influenced by early inflammatory events after reperfusion, which can be targeted for future therapeutic intervention. 相似文献
105.
Empirical analysis of the profitability of moderate grazing are presented based on sample dairy farms in Pennsylvania and New York. Net income per cow was higher for dairy farms that employed moderate intensive grazing than for dairy farms that employed extensive grazing. Income appeared to be adequate for family living expenses, but moderate intensive grazing could not be considered a high profit system. Detailed analyses of dairy farms that employed moderate and extensive grazing in northern Pennsylvania indicated that returns to management and owner equity were higher for pasture enterprises than for corn silage or hay enterprises. Positive dairy profits were related to lower feed costs. Milk production was lower on farms that employed moderate grazing than on farms that employed extensive grazing. Logit regression analysis characterized farms that employed moderate intensive grazing as oriented toward dairy rather than toward crop production; these farms had lower culling rates and a greater dependence on milk sales as a share of total sales. The reduced use of fertilizers and chemicals suggests that moderate grazing had environmentally sustainable features. 相似文献
106.
K Schom?cker T Fischer B B?ttcher SA Mraheel A Scharl B Gabruk-Szostak K Scheidhauer UJ G?hring B Meller-Rehbein SK Shukla H Schicha 《Canadian Metallurgical Quarterly》1998,37(4):134-140
AIM: The radiocytotoxic effects in estrogen receptor (ER) containing MCF-7 cells of a mamma carcinoma were investigated following incubation with [125I]E ranging from 1 h to 24 h. METHODS: The receptor status of the cells was confirmed by immunohistochemical staining. The accumulation of [125I]E in MCF-7 cells was tested in the presence and absence of radioinert E and [127I]E and in ER-negative cells in comparison to ER-positive cells. The subcellular distribution was investigated in 0.25 M Saccharose by ultra centrifugation. The radiocytotoxicity was assessed in ER-positive and negative cells by a standard colony forming assay after incubating with [125I]E (1.85 kBq/ml-55.5 kBq/ml) for 1, 2, 4, 8, 12, and 24 h. RESULTS: A significant cytotoxicity was observed only when ER-rich MCF-7-cells were incubated with [125I]E alone. The maximal cytotoxic effect was a reduction of survival fraction to 20-25%. This was achieved at radioactivity concentrations > 37 kBq/ml. Maximal effect was seen after 8 h incubation, extension of incubation time did not further increase toxicity. CONCLUSION: The results suggest that the radioactivity was bound to ER. Through their nuclear localization radioestrogens tagged with radionuclides emitting very low energy electrons (Auger electrons) bear potential for therapy by ER-mediated deposition of lethal doses of ionizing radiation to single cells without affecting neighbouring cells. But, instead of 125I the shorter-living 123I shall be used for labelling because the deciding radiation effectes occur within the first 8 h. 相似文献
107.
SV Fromm SW Mey-Tal JE Coligan C Schechter R Ehrlich 《Canadian Metallurgical Quarterly》1998,273(24):15209-15216
108.
109.
V Hurez SV Kaveri A Mouhoub G Dietrich JC Mani D Klatzmann MD Kazatchkine 《Canadian Metallurgical Quarterly》1994,1(5):269-277
The effects of intravenously administered normal immunoglobulin G (IVIg) in autoimmune diseases are dependent on the ability of IVIg to interact with surface molecules of lymphocytes. In the present study, we demonstrate the presence of anti-CD4 activity in IVIg by showing the ability of IVIg to bind to CD4 and to inhibit CD4-dependent cellular functions. Binding of IVIg to recombinant soluble human CD4 was assessed by ELISA, immunoblotting and real time analysis of complex formation. Anti-CD4 antibodies isolated from IVIg by affinity-chromatography bound to human CD4+ T cells. These anti-CD4 antibodies inhibited proliferative responses in MLR and infection of CD4+ human T cells with HIV. These results indicate that IVIg contains antibodies reactive with human CD4 and that these anti-CD4 antibodies exhibit biological functions. The presence of anti-CD4 antibodies in IVIg may be relevant to the immunoregulatory effects of normal polyspecific immunoglobulin G. 相似文献
110.
G Mbalaviele R Nishimura A Myoi M Niewolna SV Reddy D Chen J Feng D Roodman GR Mundy T Yoneda 《Canadian Metallurgical Quarterly》1998,141(6):1467-1476
Osteoclasts are multinucleated cells of hemopoietic origin that are responsible for bone resorption during physiological bone remodeling and in a variety of bone diseases. Osteoclast development requires direct heterotypic cell-cell interactions of the hemopoietic osteoclast precursors with the neighboring osteoblast/stromal cells. However, the molecular mechanisms underlying these heterotypic interactions are poorly understood. We isolated cadherin-6 isoform, denoted cadherin-6/2 from a cDNA library of human osteoclast-like cells. The isolated cadherin-6/2 is 3,423 bp in size consisting of an open reading frame of 2,115 bp, which encodes 705 amino acids. This isoform lacks 85 amino acids between positions 333 and 418 and contains 9 different amino acids in the extracellular domain compared with the previously described cadherin-6. The human osteoclast-like cells also expressed another isoform denoted cadherin-6/1 together with the cadherin-6. Introduction of cadherin-6/2 into L-cells that showed no cell-cell contact caused evident morphological changes accompanied with tight cell-cell association, indicating the cadherin-6/2 we isolated here is functional. Moreover, expression of dominant-negative or antisense cadherin-6/2 construct in bone marrow-derived mouse stromal ST2 cells, which express only cadherin-6/2, markedly impaired their ability to support osteoclast formation in a mouse coculture model of osteoclastogenesis. Our results suggest that cadherin-6 may be a contributory molecule to the heterotypic interactions between the hemopoietic osteoclast cell lineage and osteoblast/bone marrow stromal cells required for the osteoclast differentiation. Since both osteoclasts and osteoblasts/bone marrow stromal cells are the primary cells controlling physiological bone remodeling, expression of cadherin-6 isoforms in these two cell types of different origin suggests a critical role of these molecules in the relationship of osteoclast precursors and cells of osteoblastic lineage within the bone microenvironment. 相似文献