About the origins of residual stresses in <Emphasis Type="Italic">in situ</Emphasis> consolidated thermoplastic composite rings

In a context of cost reduction, in situ filament winding of thermoplastic matrix composites becomes an appealing process. As residual stresses could considerably affect the produced part, models were proposed to predict process-induced residual stresses. After developing a validated thermal model of the process, mainly three different aspects are here addressed: the continuous bonding occurring during the process, the effect of the processed layer on the structure, and the effect of the curvature of the mandrel. While stresses coming from the continuous bonding appeared to be negligible, consequent levels of stresses can be achieved due to an iterative compression of the structure by the tow (supposed to be under tension). The mandrel properties and the tow tension profile followed during winding are essential parameters that might induce several different stress states. A comparison between measured and computed end-to-end openings of split rings illustrates the accuracy of the proposed models.     

Interest of molecular functionalization for electrochemical storage

Despite great interests in electrochemical energy storage systems for numerous applications, considerable challenges remain to be overcome. Among the various approaches to improving the stability, safety, performance, and cost of these systems, molecular functionalization has recently been proved an attractive method that allows the tuning of material surface reactivity while retaining the properties of the bulk material. For this purpose, the reduction of aryldiazonium salt, which is a versatile method, is considered suitable; it forms robust covalent bonds with the material surface, however, with the formation of multilayer structures and sp³ defects (for carbon substrate) that can be detrimental to the electronic conductivity. Alternatively, non-covalent molecular functionalization based on π–π interactions using aromatic ring units has been proposed. In this review, the various advances in molecular functionalization concerning the current limitations in lithium-ion batteries and electrochemical capacitors are discussed. According to the targeted applications and required properties, both covalent and non-covalent functionalization methods have proved to be very efficient and versatile. Fundamental aspects to achieve a better understanding of the functionalization reactions as well as molecular layer properties and their effects on the electrochemical performance are also discussed. Finally, perspectives are proposed for future implementation of molecular functionalization in the field of electrochemical storage.

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The influence of bile salts on the distribution of simvastatin in the octanol/buffer system

Abstract

Introduction: Distribution coefficient (D) is useful parameter for evaluating drugs permeability properties across biological membranes, which are of importance for drugs bioavailability. Given that bile acids are intensively studied as drug permeation-modifying and -solubilizing agents, the aim of this study was to estimate the influence of sodium salts of cholic (CA), deoxycholic (DCA) and 12-monoketocholic acids (MKC) on distribution coefficient of simvastatin (SV) (lactone [SVL] and acid form [SVA]) which is a highly lipophilic compound with extremely low water solubility and bioavailability.

Methods: LogD values of SVA and SVL with or without bile salts were measured by liquid–liquid extraction in n-octanol/buffer systems at pH 5 and 7.4. SV concentrations in aqueous phase were determined by HPLC-DAD. Chem3D Ultra program was applied for computation of physico-chemical properties of analyzed compounds and their complexes.

Results: Statistically significant decrease in both SVA and SVL logD was observed for all three studied bile salts at both selected pH. MKC exerted the most pronounced effect in the case of SVA while there were no statistically significant differences between observed bile salts for SVL. The calculated physico-chemical properties of analyzed compounds and their complexes supported experimental results.

Conclusions: Our data indicate that the addition of bile salts into the n-octanol/buffer system decreases the values of SV distribution coefficient at both studied pH values. This may be the result of the formation of hydrophilic complexes increasing the solubility of SV that could consequently impact the pharmacokinetic parameters of SV and the final drug response in patients.     

功能需求与用户体验下的快递包装设计研究

目的针对目前快递包装在功能上发生的新变化,研究基于功能需求与用户体验的快递包装的设计策略,力求增加快递包装的适用性和附加价值,减少包装物废弃和资源浪费。方法秉承减量化和可循环的绿色包装设计理念,分析快递包装的功能变化与用户体验等层次的要求。结论基于功能需求与用户体验来进行的快递包装创新设计,需要外观设计独特,有趣味;信息传达智能化、突出品牌;结构设计注重保护性、针对性和便利性;通过趣味设计,交互体验,情感共鸣,来拓展快递包装的用途。     

The behavior of the fibrinolytic system during long-term orthopedic immobilization]

Our previous experimental studies on rats motionless for 7 to 60 days in special devices limiting their movements revealed a significantly increased activity of the fibrinolytic system (Groza, Artino) due to the "detention stress" rather then to the immobilization. Starting from these studies we have tried to observe the behaviour of the fibrinolytic system during long-term orthopedic immobilization (7-28 days) on patients having different injuries of the lower limb and submitted to orthopedic therapy (with or without osteosynthesis) to which an anticoagulant preventive treatment was added (heparin or low-molecular-weight substitutes such as Clivarine, Fraxiparine). We studied on 23 patients (11 male and 12 female) motionless for 14, 21, 28 days the plasma fibrinolytic activity (PFA) through euglobulin lysis time (ELT). Clinical investigation revealed that PFA did not change significantly during long-term orthopedic immobilization regardless of the duration of immobilization (14,21,28 days). Rosenfeld et al. (1994) described in healthy volunteers on bedrest for 36 hours an increase of PFA beginning at 24 hours of immobilization, this variation being capable of preventing stasis effects. Our results suggest that preventive anticoagulant therapy properly given during immobilization prevents thromboembolic events.     

Near-Entropy Hotlink Assignments

Consider a rooted tree T of arbitrary maximum degree d representing a collection of n web pages connected via a set of links, all reachable from a source home page represented by the root of T. Each web page i carries a probability p _i representative of the frequency with which it is visited. By adding hotlinks—shortcuts from a node to one of its descendents—we wish to minimize the expected number of steps l needed to visit pages from the home page, expressed as a function of the entropy H(p) of the access probabilities p. This paper introduces several new strategies for effectively assigning hotlinks in a tree. For assigning exactly one hotlink per node, our method guarantees an upper bound on l of 1.141H(p)+1 if d>2 and 1.08H(p)+2/3 if d=2. We also present the first efficient general methods for assigning at most k hotlinks per node in trees of arbitrary maximum degree, achieving bounds on l of at most \frac2H(p)log(k+1)+1\frac{2H(p)}{\log(k+1)}+1 and \fracH(p)log(k+d)-logd+1\frac{H(p)}{\log(k+d)-\log d}+1 , respectively. All our methods are strong, i.e., they provide the same guarantees on all subtrees after the assignment. We also present an algorithm implementing these methods in O(nlog n) time, an improvement over the previous O(n ²) time algorithms. Finally we prove a Ω(nlog n) lower bound on the running time of any strong method that guarantee an average access time strictly better than 2H(p).     

A tabu search with an oscillation strategy for the discriminant analysis problem

This article proposes a tabu search approach to solve a mathematical programming formulation of the linear classification problem, which consists of determining an hyperplane that separates two groups of points as well as possible in ?^m. The tabu search approach proposed is based on a non-standard formulation using linear system infeasibility. The search space is the set of bases defined on the matrix that describes the linear system. The moves are performed by pivoting on a specified row and column. On real machine learning databases, our approach compares favorably with implementations based on parametric programming and irreducible infeasible constraint sets. Additional computational results for randomly generated instances confirm that our method provides a suitable alternative to the mixed integer programming formulation that is solved by a commercial code when the number of attributes m increases.     

On the Length and Area Regularization for Multiphase Level Set Segmentation

In this paper we introduce novel regularization techniques for level set segmentation that target specifically the problem of multiphase segmentation. When the multiphase model is used to obtain a partitioning of the image in more than two regions, a new set of issues arise with respect to the single phase case in terms of regularization strategies. For example, if smoothing or shrinking each contour individually could be a good model in the single phase case, this is not necessarily true in the multiphase scenario.     

Inspection strategy for availability improvement

In this paper, an inspection strategy is proposed for systems subject to random shocks and whose state is only known through inspection. The shocks magnitudes and times between shocks arrivals are random variables. Each shock induces an amount of damage to the system which is gradually weakened as damage accumulates. The system fails when the total damage exceeds some threshold level. The proposed inspection strategy suggests to inspect the system at predetermined times T₁, T₂,...T _k . If failure is detected, then the system is repaired to a state as good as new, otherwise, it is kept operating. The expression of the system availability is derived. A numerical procedure is developed to generate an inspection sequence which maximizes the system availability. The proposed strategy has been developed for some critical subsystems of trees harvesters. An illustrative example is provided.