基于太空环境下的光纤辐照损伤理论

为了用实验室中得到的数据来模拟光纤在太空环境中的辐照损伤情况,通过将辐照损伤效应考虑为激励及响应过程的叠加,提出了一种新的理论模型。光纤在太空环境下的可能受到的最主要的辐照情况是宇宙背景辐射和太阳耀斑。针对背景辐射均匀稳定,剂量速率较小和太阳耀斑突发、剂量速率大的特点,对激励函数进行不同处理,从而得到不同的理论模型。结果表明,综合不同模型,可得到一种可行的理论方法来预测太空中的光纤损耗。     

提高并行交替式高速数字化系统分辨率的研究

本文是关于幅度非均匀取样信号理论及其应用的第二篇论文.本文首先分析了文献[1]中的偏置误差对输入信号频谱的影响,说明了提高幅度分辨率的基本原理,然后推导出了输入信号为正弦信号时附加信号的频谱表达式,提出了两种提高该系统的幅度分辨率的方法.最后进行了计算机仿真,给出了系统的有效位数和输入信号频率的关系曲线.     

A new approach of geodesic reconstruction for drusen segmentationin eye fundus images

Segmentation of bright blobs in an image is an important problem in computer vision and particularly in biomedical imaging. In retinal angiography, segmentation of drusen, a yellowish deposit located on the retina, is a serious challenge in proper diagnosis and prevention of further complications. Drusen extraction using classic segmentation methods does not lead to good results. We present a new segmentation method based on new transformations we introduced in mathematical morphology. It is based on the search for a new class of regional maxima components of the image. These maxima correspond to the regions inside the drusen. We present experimental results for drusen extraction using images containing examples having different types and shapes of drusen. We also apply our segmentation technique to two important cases of dynamic sequences of drusen images. The first case is for tracking the average gray level of a particular drusen in a sequence of angiographic images during a fluorescein exam. The second case is for registration and matching of two angiographic images from widely spaced exams in order to characterize the evolution of drusen.     

A nonlinear optical loop mirror-based linear cavity swit- chable multi-wavelength erbium-doped fiber laser

A nonlinear optical loop mirror (NOLM)-based linear cavity switchable multi-wavelength erbium-doped fiber (EDF) laser is proposed and experimentally demonstrated. Due to the characteristics of the intensity-dependent transmissivity, the NOLM can effectively mitigate the mode competition of the homogenous broadening gain medium, so that the multi-wavelength lasing can be achieved at room temperature. By adjusting the states of the polarization controllers (PCs), the number of the lasing wavelengths in the proposed laser can be adjusted flexibly from 11 to 13 with a wavelength spacing of 0.4 nm around the wavelength of 1 530 nm.     

Contribution of the C-terminal amino acid to the stability of Bacillus subtilis neutral protease

The role of the C-terminal Leu300 in maintaining thermal stabilityof the neutral protease of Bacillus subtilis was investigated.From model building studies based on the three dimensional structureof thermolysin, the neutral protease of B.thermoproteolyticus,it was conduded that this residue is located in a hydrophobicpocket composed of residues located in the C-terminal and themiddle domain. To test the hypothesis that Leu300, by contributingto a stabilizing interaction between these domains, is importantfor enzyme stability, several neutral protease mutants wereconstructed and characterized. The thermostability of the enzymewas lowered by deleting Leu300 or by replacing this residueby a smaller (Ala), a polar (Asn) or a sterically unfavourable(He) amino acid. Thermostabiity was increased upon replacingLeu300 by Phe. These results are in agreement with model-buildingstudies. The effects on thermostability observed after mutatingthe corresponding Val318 in the thermostable neutral proteaseof B.stearothermophilus were less pronounced.     

Reconstruction and quantification of the carotid artery bifurcation from 3-D ultrasound images

Three-dimensional (3-D) ultrasound is a relatively new technique, which is well suited to imaging superficial blood vessels, and potentially provides a useful, noninvasive method for generating anatomically realistic 3-D models of the peripheral vasculature. Such models are essential for accurate simulation of blood flow using computational fluid dynamics (CFD), but may also be used to quantify atherosclerotic plaque more comprehensively than routine clinical methods. In this paper, we present a spline-based method for reconstructing the normal and diseased carotid artery bifurcation from images acquired using a freehand 3-D ultrasound system. The vessel wall (intima-media interface) and lumen surfaces are represented by a geometric model defined using smoothing splines. Using this coupled wall-lumen model, we demonstrate how plaque may be analyzed automatically to provide a comprehensive set of quantitative measures of size and shape, including established clinical measures, such as degree of (diameter) stenosis. The geometric accuracy of 3-D ultrasound reconstruction is assessed using pulsatile phantoms of the carotid bifurcation, and we conclude by demonstrating the in vivo application of the algorithms outlined to 3-D ultrasound scans from a series of patient carotid arteries.     

Operator dependence of 3-D ultrasound-based computational fluid dynamics for the carotid bifurcation

The association between vascular wall shear stress (WSS) and the local development of atherosclerotic plaque makes estimation of in vivo WSS of considerable interest. Three-dimensional ultrasound (3DUS) combined with computational fluid dynamics (CFD) provides a potentially valuable tool for acquiring subject-specific WSS, but the interoperator and intraoperator variability associated with WSS calculations using this method is not known. Here, the accuracy, reproducibility and operator dependence of 3DUS-based computational fluid dynamics were examined through a phantom and in vivo studies. A carotid phantom was scanned and reconstructed by two operators. In the in vivo study, four operators scanned a healthy subject a total of 11 times, and their scan data were processed by three individuals. The study showed that with some basic training, operators could acquire accurate carotid geometry for flow reconstructions. The variability of measured cross-sectional area and predicted shear stress was 8.17% and 0.193 N/m/sup 2/ respectively for the in vivo study. It was shown that the variability of the examined parameters was more dependent on the scan operators than the image processing operator. The range of variability of geometrical and flow parameters reported here can be used as a reference for future in vivo studies using the 3DUS-based CFD approach.     

Feasibility and performance evaluation of a 6LoWPAN‐enabled platform for ubiquitous healthcare monitoring

Technology has revolutionized medical practices by enabling more convenient and non‐intrusive monitoring of patient's health, leading to next generation ubiquitous healthcare (u‐healthcare). The exploitation of the Internet protocol version 6 addressing space along with the miniaturization of electronic devices has fostered providing interoperability and connectivity of wearable sensor devices in wireless body area networks to the Internet of Things. In this paper, we propose to integrate the IPv6 over low power wireless personal area network (6LoWPAN) to the u‐healthcare monitoring system architecture. The main objective is to study the feasibility of the 6LoWPAN‐enabled platform in real‐world scenarios dealing with medical data. The performance evaluation of this platform is carried out initially through simulations using OMNet++ and then supported by an experimental study using sensor motes and a customized micro‐computing unit. Performance metrics such as throughput, end‐to‐end delay, packet error rate, and energy consumption are investigated under acute health conditions, where patient's health information has to be sent continuously and at maximum rate to the care provider. The obtained results show that the proposed 6LoWPAN solution fulfills the main quality of service requirements of u‐healthcare applications. Copyright © 2015 John Wiley & Sons, Ltd.     

Biocompatible Nanoparticles with Aggregation‐Induced Emission Characteristics as Far‐Red/Near‐Infrared Fluorescent Bioprobes for In Vitro and In Vivo Imaging Applications

Light emission of 2‐(2,6‐bis((E)‐4‐(diphenylamino)styryl)‐4H‐pyran‐4‐ylidene)malononitrile (TPA‐DCM) is weakened by aggregate formation. Attaching tetraphenylethene (TPE) units as terminals to TPA‐DCM dramatically changes its emission behavior: the resulting fluorogen, 2‐(2,6‐bis((E)‐4‐(phenyl(4′‐(1,2,2‐triphenylvinyl)‐[1,1′‐biphenyl]‐4‐yl)amino)styryl)‐4H‐pyran‐4‐ylidene)malononitrile (TPE‐TPA‐DCM), is more emissive in the aggregate state, showing the novel phenomenon of aggregation‐induced emission (AIE). Formulation of TPE‐TPA‐DCM using bovine serum albumin (BSA) as the polymer matrix yields uniformly sized protein nanoparticles (NPs) with high brightness and low cytotoxicity. Applications of the fluorogen‐loaded BSA NPs for in vitro and in vivo far‐red/near‐infrared (FR/NIR) bioimaging are successfully demonstrated using MCF‐7 breast‐cancer cells and a murine hepatoma‐22 (H₂₂)‐tumor‐bearing mouse model, respectively. The AIE‐active fluorogen‐loaded BSA NPs show an excellent cancer cell uptake and a prominent tumor‐targeting ability in vivo due to the enhanced permeability and retention effect.