Management of the patient with aortic root disease and aortic insufficiency

There is no single standardized method of repair for the anatomic variations in aortic root pathology, which may include dissection, aneurysmal dilation, and valve disease and can occur at the annulus, sinuses of Valsalva, or the sinotubular junction. Composite valve/graft replacement, valve resuspension, and allograft each play a significant role in aortic root therapy, but none is applicable in all cases. Patient age, Marfan's syndrome, endocarditis, and previous valve replacement are examples of some of the wide variations in delineating factors.     

Online product review as an indicator of users’ degree of innovativeness and product adoption time: a longitudinal analysis of text reviews

Online reviews have become extremely valuable sources of information about products and their customers as electronic commerce continues to proliferate rapidly. Previous research has shown that reviews of a product change and evolve over its life. Identifying and understanding patterns of change in reviews and the forces that shape them is an underexplored topic with substantial potential for predicting and improving the market performance of products. In this study, we analyze review text of nearly 50 products over the course of their lives. Our longitudinal analysis of reviews reveals changes in certain personality-related characteristics of buyers in ways that are consistent with the predictions of product adoption and diffusion theories. The main findings and conclusions still hold when we replicate the same procedure on reviews of a different product category. Accordingly, based on online user-generated content in the form of online reviews, this research introduces a novel empirical method for identifying the product adoption and diffusion stage. Implications of the study for theory, methodology, and practice are discussed.     

Thyroid hormone receptor genes of neotenic amphibians

Since thyroid hormones play a pivotal role in amphibian metamorphosis we used PCR to amplify DNA fragments corresponding to a portion of the ligand-binding domain of the thyroid hormone receptor (TR) genes in several neotenic amphibians: the obligatory neotenic members of the family Proteidea the mudpuppy Necturus maculosus and Proteus anguinus as well as two members of the facultative neotenic Ambystoma genus: the axolotl Ambystoma mexicanum and the tiger salamander Ambystoma tigrinum. In addition, we looked for TR genes in the genome of an apode Typhlonectes compressicaudus. TR genes were found in all these species including the obligatory neotenic ones. The PCR fragments obtained encompass both the C and E domains and correspond to alpha and beta genes. Their sequences appear to be normal, suggesting that there is no acceleration of evolutionary rates in the TR genes of neotenic amphibians. This result is not surprising for Ambystomatidae, which are known to respond to T3 (3,3',5-triiodothyronine) but is not in agreement with biochemical and biological data showing that Proteidea cannot respond to thyroid hormones. Interestingly, by RT-PCR analysis we observed a high expression levels of TRalpha in gills, intestine, and muscles of Necturus as well as in the liver of Ambystoma mexicanum, whereas TRbeta expression was only detected in Ambystoma mexicanum but not in Necturus. Such a differential expression pattern of TRalpha and TRbeta may explain the neoteny in Proteidea. The cloning of thyroid-hormone-receptor gene fragments from these species will allow the molecular study of their failure to undergo metamorphosis.     

Analysis of Eastern Mediterranean Oak Forests Over the Period 1965–2003 Using Landscape Indices on a Patch Basis

Although Eastern Mediterranean forests have been exploited for many years, the changing trends in the past 40 years require detailed investigations. Forests in the coastal zone of Lebanon are witnessing major changes mainly because of chaotic urbanisation. The study area at the coastal zone of Lebanon has 96% of its forest cover under oak coppice. The aim of this study is to investigate the applicability of landscape indices on oak forests especially their ability to detect changes between 1965 and 2003. It uses forest canopy closure as another indicator of forest destruction. The 1965 forest map was first checked for its accuracy before being used to extract patch delineations and canopy closures. Landcover types for 2003 were obtained by classifying a SPOT 5 satellite image. FRAGSTATS software was utilised on the 1965 map on a patch basis to calculate patch shapes and sizes. These indices and canopy closures data were investigated for correlation purposes with patterns of forest loss. The edge distances between forest patches in 1965 and new forest patches in 2003 were computed to analyze regeneration processes. Results show that although older forest patches have shown a 48% loss in area, total forest area reached 83%. Abandoned agricultural lands have become new forest. Smaller forest patches (< 40 ha) showed greater losses than large ones. Small and open forest patches recorded greater loss than large and dense patches. Shape indices show no correlation with forest loss. Clearance for agriculture covered 30% of the pre-existing forests, while urban developments accounted for just 4% of forest loss. This research highlights the great need for comprehensive studies of forests using landscape analyses. Such analyses help managers develop practical and relevant conservation measures.