全文获取类型
收费全文 | 156篇 |
免费 | 6篇 |
专业分类
电工技术 | 4篇 |
化学工业 | 24篇 |
金属工艺 | 1篇 |
机械仪表 | 2篇 |
建筑科学 | 6篇 |
能源动力 | 19篇 |
轻工业 | 17篇 |
水利工程 | 2篇 |
石油天然气 | 2篇 |
无线电 | 17篇 |
一般工业技术 | 31篇 |
冶金工业 | 9篇 |
原子能技术 | 2篇 |
自动化技术 | 26篇 |
出版年
2023年 | 3篇 |
2022年 | 11篇 |
2021年 | 13篇 |
2020年 | 14篇 |
2019年 | 11篇 |
2018年 | 6篇 |
2017年 | 9篇 |
2016年 | 3篇 |
2015年 | 3篇 |
2014年 | 4篇 |
2013年 | 9篇 |
2012年 | 11篇 |
2011年 | 15篇 |
2010年 | 10篇 |
2009年 | 8篇 |
2008年 | 3篇 |
2007年 | 5篇 |
2006年 | 2篇 |
2005年 | 2篇 |
2004年 | 1篇 |
2002年 | 6篇 |
2000年 | 1篇 |
1995年 | 1篇 |
1989年 | 2篇 |
1988年 | 1篇 |
1984年 | 1篇 |
1980年 | 1篇 |
1977年 | 2篇 |
1976年 | 2篇 |
1975年 | 1篇 |
1973年 | 1篇 |
排序方式: 共有162条查询结果,搜索用时 15 毫秒
91.
Numerical optimization of axial turbine with self‐pitch‐controlled blades used for wave energy conversion 下载免费PDF全文
Wells turbines are among the most practical wave energy converters despite their low aerodynamic efficiency and power produced. It is proposed to improve the performance of Wells turbines by optimizing the blade pitch angle. Optimization is implemented using a fully automated optimization algorithm. Two different airfoil geometries are numerically investigated: the standard NACA 0021 and an airfoil with an optimized profile. Numerical results show that each airfoil has its own optimum blade pitch angle. The present computational fluid dynamics optimization results show that the optimum blade pitch angle for NACA 0021 is +0.3° while that of the airfoil with an optimized profile equals +0.6°.The performance of the investigated airfoils is substantially improved by setting the blades at the optimum blade pitch angle. Both the turbine efficiency and tangential force coefficient are improved, especially at low flow rate and during turbine startup. Up to 4.3% average increase in turbine efficiency is achieved by optimizing the blade pitch angle. A slight improvement of the tangential force coefficient and decrease of the axial force coefficient are also obtained. A tangible increase of the stall‐free operating range is also achieved by optimizing the blade pitch angle. Copyright © 2013 John Wiley & Sons, Ltd. 相似文献
92.
Rania Hamdy Bahgat Fayed Ahmed Mostafa Noura M. Abo Shama Sara Hussein Mahmoud Chetan Hasmukh Mehta Yogendra Nayak Sameh S. M. Soliman 《International journal of molecular sciences》2021,22(16)
Unfortunately, COVID-19 is still a threat to humankind and has a dramatic impact on human health, social life, the world economy, and food security. With the limited number of suggested therapies under clinical trials, the discovery of novel therapeutic agents is essential. Here, a previously identified anti-SARS-CoV-2 compound named Compound 13 (1,2,5-Oxadiazole-3-carboximidic acid, 4,4′-(methylenediimino) bis,bis[[(2-hydroxyphenyl)methylene]hydrazide) was subjected to an iterated virtual screening against SARS-CoV-2 Mpro using a combination of Ligand Designer and PathFinder. PathFinder, a computational reaction enumeration tool, was used for the rapid generation of enumerated structures via default reaction library. Ligand designer was employed for the computerized lead optimization and selection of the best structural modification that resulted in a favorable ligand–protein complex. The obtained compounds that showed the best binding to Mpro were re-screened against TMPRSS2, leading to the identification of 20 shared compounds. The compounds were further visually inspected, which resulted in the identification of five shared compounds M1–5 with dual binding affinity. In vitro evaluation and enzyme inhibition assay indicated that M3, an analogue of Compound 13 afforded by replacing the phenolic moiety with pyridinyl, possesses an improved antiviral activity and safety. M3 displayed in vitro antiviral activity with IC50 0.016 µM and Mpro inhibition activity with IC50 0.013 µM, 7-fold more potent than the parent Compound 13 and potent than the antivirals drugs that are currently under clinical trials. Moreover, M3 showed potent activity against human TMPRSS2 and furin enzymes with IC50 0.05, and 0.08 µM, respectively. Molecular docking, WaterMap analysis, molecular dynamics simulation, and R-group analysis confirmed the superiority of the binding fit to M3 with the target enzymes. WaterMap analysis calculated the thermodynamic properties of the hydration site in the binding pocket that significantly affects the biological activity. Loading M3 on zinc oxide nanoparticles (ZnO NPs) increased the antiviral activity of the compound 1.5-fold, while maintaining a higher safety profile. In conclusion, lead optimized discovery following an iterated virtual screening in association with molecular docking and biological evaluation revealed a novel compound named M3 with promising dual activity against SARS-CoV-2. The compound deserves further investigation for potential clinical-based studies. 相似文献
93.
Sameh S. Badie Amgad F. Morgan Girgis Maher K. Tadros Nghi T. Nguyen 《Canadian Metallurgical Quarterly》2010,15(5):482-492
The AASHTO LRFD Bridge Design Specifications state that the spacing between the shear connectors for steel girders should not exceed 610 mm (24 in.). This decision was made based on research conducted more than three decades ago. The goal of this research is to investigate the possibility of extending this limit to 1,220 mm (48 in.) for stud clusters used with full-depth precast concrete deck panels installed on steel girders. This paper presents the history of the 610 mm (24 in.) limit, various formulas developed to calculate fatigue and design capacity for stud clusters and concerns about extending the current LRFD limit. This paper also presents information on the first phase of the experimental investigation, which is conducted on push-off specimens to validate extending the limit to 1,220 mm (48 in.). 相似文献
94.
Mohamed S. Ghidaoui Sameh G. S. Mansour Ming Zhao 《Canadian Metallurgical Quarterly》2002,128(10):917-924
Two of the existing turbulence water hammer models, namely the two-layer and the five-layer eddy viscosity models, are implemented and analyzed and the accuracy of their quasi-steady and axisymmetric assumptions evaluated. In addition, a dimensionless parameter P (ratio of the time scale of radial diffusion of shear to the time scale of wave propagation) for assessing the accuracy of quasi-steady turbulence modeling in water hammer problems is developed and applied. It is found that the results of both models are in reasonable agreement, confirming that the turbulence modeling of water hammer flows is insensitive to the magnitude and distribution of the eddy viscosity within the pipe core. Comparison of model results with available data shows that the quasi-steady assumption becomes more accurate as the dimensionless parameter P increases. Furthermore, the analysis shows that the quasi-steady assumption is highly accurate as long as the simulation time is below the diffusion time scale and that this assumption causes an almost linear increase in the difference between model results and data with time. The accuracy of the flow axisymmetry assumption is evaluated by applying both models to a water hammer problem where flow asymmetry has been observed experimentally. It is found that the difference between models and data grows exponentially and reaches 100% after six wave periods. 相似文献
95.
This paper describes algorithms for solving narrow banded systems and the Helmholtz difference equations that are suitable for multiprocessing systems. The organization of the algorithms highlight the large grain parallelism inherent in the problems. 相似文献
96.
Sonic analysis in cut-off grinding of concrete 总被引:1,自引:0,他引:1
Berend Denkena David Boehnke Benjamin Konopatzki Josef-Christian Buhl Sameh Rahman Lars Robben 《Production Engineering》2008,2(2):209-218
The machining of concrete with diamond cutting discs is nowadays often done with all-purpose tools and unadjusted machine
parameters due to unknown material properties. The inhomogeneous structure of concrete ideally requires continuous process
monitoring and real time adjustment of machine parameters. A joined research project of the Institute of Production Engineering
and Machine Tools (IFW) and the Institute of Mineralogy (IM) is aimed at enabling process monitoring by means of using acoustic
emission (AE) and airborne sound generated by the grinding tools. This paper presents the applied methods and first results.
AE and airborne sound measurements show a correlation between the signal intensity and the aggregates present in the concrete.
It is shown here that spectral analysis of measured signals can give information about the process and the workpiece structure
being cut.
The investigations presented in this paper are kindly supported by the German Research Foundation (DFG) within the project
“Method for characterization of the machinability of brittle-hard compound material”. 相似文献
97.
Hassan Shikshaky Eman Abdelnaby Ahmed Ali Mostafa Anwar Aya Osama Shahd Ezzeldin Antony Nasr Sebaey Mahgoub Sameh Magdeldin 《International journal of molecular sciences》2022,23(18)
Metabolomics is a potential approach to paving new avenues for clinical diagnosis, molecular medicine, and therapeutic drug monitoring and development. The conventional metabolomics analysis pipeline depends on the data-independent acquisition (DIA) technique. Although powerful, it still suffers from stochastic, non-reproducible ion selection across samples. Despite the presence of different metabolomics workbenches, metabolite identification remains a tedious and time-consuming task. Consequently, sequential windowed acquisition of all theoretical MS (SWATH) acquisition has attracted much attention to overcome this limitation. This article aims to develop a novel SWATH platform for data analysis with a generation of an accurate mass spectral library for metabolite identification using SWATH acquisition. The workflow was validated using inclusion/exclusion compound lists. The false-positive identification was 3.4% from the non-endogenous drugs with 96.6% specificity. The workflow has proven to overcome background noise despite the complexity of the SWATH sample. From the Human Metabolome Database (HMDB), 1282 compounds were tested in various biological samples to demonstrate the feasibility of the workflow. The current study identified 377 compounds in positive and 303 in negative modes with 392 unique non-redundant metabolites. Finally, a free software tool, SASA, was developed to analyze SWATH-acquired samples using the proposed pipeline. 相似文献
98.
Rania Hamdy Arwyn T. Jones Mohamed El-Sadek Alshaimaa M. Hamoda Sarra B. Shakartalla Zainab M. AL Shareef Sameh S. M. Soliman Andrew D. Westwell 《International journal of molecular sciences》2021,22(22)
A series of 3-(6-substituted phenyl-[1,2,4]-triazolo[3,4-b]-[1,3,4]-thiadiazol-3-yl)-1H-indoles (5a–l) were designed, synthesized and evaluated for anti-apoptotic Bcl-2-inhibitory activity. Synthesis of the target compounds was readily accomplished through a reaction of acyl hydrazide (1) with carbon disulfide in the presence of alcoholic potassium hydroxide to afford the corresponding intermediate potassium thiocarbamate salt (2), which underwent cyclization reaction in the presence of excess hydrazine hydrate to the corresponding triazole thiol (3). Further cyclisation reaction with substituted benzoyl chloride derivatives in the presence of phosphorous oxychloride afforded the final 6-phenyl-indol-3-yl [1,2,4]-triazolo[3,4-b]-[1,3,4]-thiadiazole compounds (5a–l). The novel series showed selective sub-micromolar IC50 growth-inhibitory activity against Bcl-2-expressing human cancer cell lines. The most potent 6-(2,4-dimethoxyphenyl) substituted analogue (5k) showed selective IC50 values of 0.31–0.7 µM against Bcl-2-expressing cell lines without inhibiting the Bcl-2-negative cell line (Jurkat). ELISA binding affinity assay (interruption of Bcl-2-Bim interaction) showed potent binding affinity for (5k) with an IC50 value of 0.32 µM. Moreover, it fulfils drug likeness criteria as a promising drug candidate. 相似文献
99.
In the current study, a monocrystalline Si photovoltaic(PV) cell was modeled using solar cell capacitance simulator(SCAPS) to demonstrate the optoelectronic performance of the cell under harsh environmental conditions. Harsh conditions are simulated in terms of wind speed and temperature fluctuations within the presence of a dust layer. All models are evaluated with respect to a bare model with no dust layer accumulated and operating under standard test conditions(STC). Accordingly, the PV under... 相似文献
100.
This paper presents a numerical investigation of laminar mixed convection cooling of heat source embedded on the bottom wall of an enclosure filled with nanofluids. The transport equations for a Newtonian fluid are solved numerically with a finite volume approach using the SIMPLE algorithm. The influences of governing parameters, namely, Rayleigh number location and geometry of the heat source, the type of nanofluid and solid volume fraction of nanoparticles on the cooling performance is studied. The present results are validated by favourable comparisons with previously published results. The results of the problem are presented in graphical and tabular forms and discussed. © 2011 Canadian Society for Chemical Engineering 相似文献