Fluorescence and nonlinear optical properties of non-aggregating hexadeca-substituted phthalocyanine

Highly non-aggregating hexadeca-substituted phthalocyanine (Pc) complexes were prepared and their fluorescence and nonlinear optical properties were studied. Three visible fluorescence bands were observed when the Pc complexes were excited at 355 nm and found to be concentration dependent. They are attributed to the optical transitions S₂ → S₀ at 415 nm, T₂ → T₁ at 630 nm, and S₂ → S₁ at 755 nm. Nonlinear absorptive and refractive effects were measured with the help of Z-scan technique. Saturation absorption was observed at 632.8 nm where the nonlinear absorption coefficient is found to be very large (β = −2.8 × 10⁻² cm/W) and the refractive nonlinear coefficient γ = −9.5 × 10⁻¹¹ cm²/W. In the transparency domain at 532 nm, reverse absorption saturation is observed and β and γ are found to be 17.5 and 15.5 times smaller, respectively. Optical limiting performances are measured in the absorption and transparency domains. Purely refractive-based optical limiting at 632.8 nm is found to have a threshold of 0.16 kW/cm², lower than the reverse absorption saturation and refractive-based optical limiting of 0.90 kW/cm² at 532 nm.     

Driving while conversing: Cell phones that distract and passengers who react

The research systematically compared the driving performance and conversational patterns of drivers speaking with in-car passengers, hands-free cell phones, and remote passengers who could see the driver's current driving situation (via a window into a driving simulator). Driving performance suffered during cell phone and remote passenger conversations as compared with in-car passenger conversations and no-conversation controls in terms of their approach speeds, reaction times, and avoidance of road and traffic hazards. Of particular interest was the phenomenon of conversation suppression, the tendency for passengers to slow their rates of conversation as the driver approached a hazard. On some occasions these passengers also offered alerting comments, warning the driver of an approaching hazard. Neither conversation suppression nor alerting comments were present during cell phone conversations. Remote passengers displayed low levels of alerting comments and conversation suppression, but not enough to avoid negative effects on driving performance. The data suggested that conversation modulation was a key factor in maintaining driving performance and that seeing the road and traffic was not sufficient to produce it. A second experiment investigated whether a cell phone modified to emit warning tones could alleviate some of the adverse effects typically associated with cell phone conversations. The modified cell phone produced discourse patterns that were similar to passenger conversations and driving performance nearly as good as that of drivers who were not conversing. This latter finding supported the argument that conversation modulation is a key ingredient in avoiding adverse effects of conversations with drivers, rather than the physical presence of an in-car passenger.     

In situ collagen assembly for integrating microfabricated three-dimensional cell-seeded matrices

Microscale fabrication of three-dimensional (3D) extracellular matrices (ECMs) can be used to mimic the often inhomogeneous and anisotropic properties of native tissues and to construct in vitro cellular microenvironments. Cellular contraction of fibrous natural ECMs (such as fibrin and collagen I) can detach matrices from their surroundings and destroy intended geometry. Here, we demonstrate in situ collagen fibre assembly (the nucleation and growth of new collagen fibres from preformed collagen fibres at an interface) to anchor together multiple phases of cell-seeded 3D hydrogel-based matrices against cellular contractile forces. We apply this technique to stably interface multiple microfabricated 3D natural matrices (containing collagen I, Matrigel, fibrin or alginate); each phase can be seeded with cells and designed to permit cell spreading. With collagen-fibre-mediated interfacing, microfabricated 3D matrices maintain stable interfaces (the individual phases do not separate from each other) over long-term culture (at least 3 weeks) and support spatially restricted development of multicellular structures within designed patterns. The technique enables construction of well-defined and stable patterns of a variety of 3D ECMs formed by diverse mechanisms (including temperature-, ion- and enzyme-mediated crosslinking), and presents a simple approach to interface multiple 3D matrices for biological studies and tissue engineering.     

Phase-error correction in digital holography

The quality of images computed from digital holograms or heterodyne array imaging is degraded by phase errors in the object and/or reference beams at the time of measurement. This paper describes computer simulations used to compare the performance of digital shearing laser interferometry and various sharpness metrics for the correction of such phase errors when imaging a diffuse object. These algorithms are intended for scenarios in which multiple holograms can be recorded with independent object speckle realizations and a static phase error. Algorithm performance is explored as a function of the number of available speckle realizations and signal-to-noise ratio (SNR). The performance of various sharpness metrics is examined in detail and is shown to vary widely. Under ideal conditions with >15 speckle realizations and high SNR, phase corrections better than lambda/50 root-mean-square (RMS) were obtained. Corrections better than lambda/10 RMS were obtained in the high SNR regime with as few as two speckle realizations and at object beam signal levels as low as 2.5 photons/speckle with six speckle realizations.     

A study of tensile properties in Al–Si–Cu and Al–Si–Mg alloys: Effect of β-iron intermetallics and porosity

The effect of β-iron intermetallics and porosity on the tensile properties in cast Al–Si–Cu and Al–Si–Mg alloys were investigated for this research study, using experimental and industrial 319.2 alloys, and industrial A356.2 alloys. The results showed that the alloy ductility and ultimate tensile strength (UTS) were subject to deterioration as a result of an increase in the size of β-iron intermetallics, most noticeable up to β-iron intermetallic lengths of 100 μm in 319.2 alloys, or 70 μm in A356.2 alloys. An increase in the size of the porosity was also deleterious to alloy ductility and UTS. Although tensile properties are interpreted by means of UTS vs. log elongation plots in the present study, the properties for all sample conditions were best interpreted by means of log UTS vs. log elongation plots, where the properties increased linearly between conditions of low cooling rate–high Fe and high cooling rate–low Fe. The results are explained in terms of the β-Al₅FeSi platelet size and porosity values obtained.     

Real-time microfluidic system for studying mammalian cells in 3D microenvironments

We describe a microfluidic system that can control, in real time, the microenvironments of mammalian cells in naturally derived 3D extracellular matrix (ECM). This chip combines pneumatically actuated valves with an individually addressable array of 3D cell-laden ECM; actuation of valves determines the pathways for delivering reagents through the chip and for exchanging diffusible factors between cell chambers. To promote rapid perfusion of reagents through 3D gels (with complete exchange of reagents within the gel in seconds), we created conduits above the gels for fluid flow, and microposts to stabilize the gels under high perfusion rates. As a biological demonstration, we studied spatially segregated mouse embryonic stem cells and mouse embryonic fibroblasts embedded in 3D Matrigel over days of culture. Overall, this system may be useful for high-throughput screening, single-cell analysis and studies of cell-cell communication, where rapid control of 3D cellular microenvironments is desired.     

The additional dose to radiosensitive organs caused by using under-collimated X-ray beams in neonatal intensive care radiography

Radiographic technique and exposure parameters were recorded in five Israeli Neonatal Intensive Care Units for chest, abdomen and both chest and abdomen X-ray examinations. Equivalent dose and effective dose values were calculated according to actual examination field size borders and proper technique field size recommendations using PCXMC, a PC-based Monte Carlo program. Exposure of larger than required body areas resulted in an increase of the organ doses by factors of up to 162 (testes), 162 (thyroid) and 8 (thyroid) for chest, abdomen and both chest and abdomen examinations, respectively. These exposures increased the average effective dose by factors of 2.0, 1.9 and 1.3 for the chest, abdomen and both chest and abdomen examinations, respectively. Differences in exposure parameters were found between the different neonatal intensive care units-tube voltage, current-time product and focal to skin distance differences up to 13, 44 and 22%, respectively. Reduction of at least 50% of neonate exposure is feasible and can be implemented using existing methodology without any additional costs.     

The complex method applied to optimal truss configuration

The Complex Method of Box is applied to the determination of optimal member sizes and geometric configuration for minimum weight of 3-dimensional truss structures. Design constraints include bounds on member size, joint coordinates, member stresses, Euler buckling and joint displacements. The displacement method of structural analysis is used and the system is assumed to be linearly elastic. Statically indeterminate structures under multiple loading conditions can be optimized and the sizing as well as the geometric design variables may be linked. Limited topological changes are permitted for designs which have small member forces.The design spaces for sizing and geometric variables are separated. Geometry is modified by the Complex Method and member sizes by stress ratio and a scaling procedure for stiffness.The method is applied to two numerical examples from the literature. Results indicate favourable design improvements and rates of convergence. Substantial additional improvement resulting from member deletion is demonstrated.     

A Feedback Macro－Scheduler＋

A multi-class macro-scheduler is described in this paper.The scheduler periodically determines the number of jobs from each class that should be activated to minimize a weighted sum of the mean system residence time without saturating the system.The computation is based on the estimated system workload in the next interval.Thus it is adaptive to workload variation.The service provied to each class (Specifically,the mean response time)may be adjusted by changing the weight associated with the job class.The scheme is based on mathematical modelling.The solution is obtained through the use of queuing theory,operational analysis and opitmization theory.Exponential smoothing technique is employed to reduce the error of estimating the value of the model parameters.Simulation resuts show the scheme to be both stable and robust.Perfomance improvement over some of the existing schemes(the 50%,L=S and the Knee criteria)is signifcant under some workloads.The overhead involved in its implementation is acceptable and the errors due to some of the assumptions used in the fromulation and solution of the model are discussed.