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排序方式: 共有1476条查询结果,搜索用时 15 毫秒
81.
Satoru Shindo Irma Josefina Savitri Takenobu Ishii Atsushi Ikeda Roodelyne Pierrelus Alireza Heidari Keisuke Okubo Shin Nakamura Umadevi Kandalam Mohamad Rawas-Qalaji Elizabeth Leon Maria Rita Pastore Patrick Hardigan Toshihisa Kawai 《International journal of molecular sciences》2022,23(6)
Effects of the antiosteoblastogenesis factor Semaphorin 4D (Sema4D), expressed by thrombin-activated platelets (TPs), on osteoblastogenesis, as well as osteoclastogenesis, were investigated in vitro. Intact platelets released both Sema4D and IGF-1. However, in response to stimulation with thrombin, platelets upregulated the release of Sema4D, but not IGF-1. Anti-Sema4D-neutralizing monoclonal antibody (mAb) upregulated TP-mediated osteoblastogenesis in MC3T3-E1 osteoblast precursors. MC3T3-E1 cells exposed to TPs induced phosphorylation of Akt and ERK further upregulated by the addition of anti-sema4D-mAb, suggesting the suppressive effects of TP-expressing Sema4D on osteoblastogenesis. On the other hand, TPs promoted RANKL-mediated osteoclastogenesis in the primary culture of bone-marrow-derived mononuclear cells (BMMCs). Among the known three receptors of Sema4D, including Plexin B1, Plexin B2 and CD72, little Plexin B2 was detected, and no Plexin B1 was detected, but a high level of CD72 mRNA was detected in RANKL-stimulated BMMCs by qPCR. Both anti-Sema4D-mAb and anti-CD72-mAb suppressed RANKL-induced osteoclast formation and bone resorptive activity, suggesting that Sema4D released by TPs promotes osteoclastogenesis via ligation to a CD72 receptor. This study demonstrated that Sema4D released by TPs suppresses osteogenic activity and promotes osteoclastogenesis, suggesting the novel property of platelets in bone-remodeling processes. 相似文献
82.
Shiv Shankhar Kaundun Satoru Matsumoto 《Journal of the science of food and agriculture》2011,91(14):2660-2663
BACKGROUND: Tea is the most consumed beverage worldwide after water. Yet very little is known about the genetics of tea in comparison with other crop species. Here we have taken advantage of the polymorphic nature of microsatellite DNA to investigate the mode of chloroplast inheritance in tea, Camellia sinensis (L.) O. Kuntze. This is important for the correct interpretation of phylogeny and introgression data as well as assessing the suitability of chloroplast transformation as a means for transgene containment in tea. RESULTS: The study was based on six Japanese tea cultivars, namely Aj2, CK23, Hatsumomiji, Nka05, Yamanoibuki and Kanayamidori used to generate four informative families. The parental pairs in the crosses differed at a single chlroroplast locus with respect to an imperfect microsatellite repeat of 16 nucleotide bases. In agreement with earlier cytological studies, all 61 progeny displayed a cpDNA profile that was consistent with the maternal inheritance of chloroplasts in tea. CONCLUSIONS: The data generated here provide the first molecular evidence of the plastid inheritance in tea. However, we suggest that additional families and polymorphic markers be screened for increasing the confidence in the observed maternal inheritance of chloroplasts in this important crop species. Copyright © 2011 Society of Chemical Industry 相似文献
83.
We determined phase equilibria in the Co-rich Co-Al-W-Ti quaternary system at a temperature range between 900 °C and 1200 °C with a close attention to the thermodynamic stability of the γ′-Co3(Al, W, Ti) (L12) phase, based on micro-structure observation and electron microprobe analysis on bulk alloy samples heat-treated for periods up to 2000 h. In the quaternary system the single phase field of γ′ extends from the Co-Ti binary edge to a composition of Co-5Al-8.5W-8Ti (in at.%) at 900 °C. At the tip of the single phase field, the γ′ phase is in equilibrium with the γ-Co (A1), Co2AlTi (L21) and Co3W (D019) phases. The constructed vertical section of phase diagram between Co-9.4Al-9.6W and Co-16.5Ti indicates that there is a narrow composition range around Co-4.5Al-5.4W-7.5Ti in which the γ single phase field exists at high temperatures above 1200 °C and two-phase of γ+γ′ is thermodynamically stable at low temperatures below 1100 °C. 相似文献
84.
85.
Neidert Pamela L.; Dozier Claudia L.; Iwata Brian A.; Hafen Megan 《Canadian Metallurgical Quarterly》2010,7(2):103
Individuals with intellectual and developmental disabilities (IDD) have deficits in adaptive behavior, slow rates of learning, and behavior disorders that interfere with learning or place them or others at risk. Since the 1960s, researchers and clinicians in the field of applied behavior analysis have used methods based on principles of learning to increase adaptive behavior and decrease the occurrence of behavior disorders of individuals with IDD. This article provides an overview of assessment and treatment strategies used in behavior analysis to effect positive changes in the quality of life for individuals with IDD and presents an illustrative case study. (PsycINFO Database Record (c) 2010 APA, all rights reserved) 相似文献
86.
Satoru TakeshitaTatsuya Watanabe Tetsuhiko Isobe Tomohiro SawayamaSeiji Niikura 《Optical Materials》2011,33(3):323-326
YVO4:Bi3+,Eu3+ nanophosphor synthesized by the citrate route shows the photobleaching behavior, i.e., the decrease in photoluminescence intensity under the continuous irradiation of excitation light. This photobleaching property is remarkably suppressed by the washing post-treatment combined with centrifugation and the hydrothermal post-treatment. A relation between the fraction of photobleach and the amount of citrate ions coordinating to metallic ions at the surface of nanoparticles verifies that the photobleaching behavior of YVO4:Bi3+,Eu3+ nanophosphor originates from the redox reaction between the citrate ions and V5+ in YVO4 host crystal. The long-term light fastness test reveals that the hydrothermally treated YVO4:Bi3+,Eu3+ nanophosphor has sufficient photostability for practical use over 15 years outside. 相似文献
87.
This study advocates a multi-dimensional urban planning strategy to help combat climate change under local—and not national—policies. However, the literature does not provide adequate guidance to local governments seeking to enhance urbanization and in turn reduce vehicular carbon dioxide (CO2) emissions. Therefore, this study sheds light on the effects of the following four urban planning instruments on vehicular CO2 emissions: urbanization promoting areas, urbanization control areas, urban planning taxes and property taxes. Using Japanese city-level data from 1990 to 2010, we find that the two urbanization area planning instruments and the urban planning taxes help lower emissions by increasing population density in low-density cities and that property taxes help reduce emissions in high-density cities. However, the increased population density associated with these instruments can lead to other negative outcomes, including increased traffic accidents, increased crime and a decrease in the facility condition index. City governments should consider complementary policies to mitigate such negative outcomes when employing planning instruments aiming to increase population density. 相似文献
88.
A method to detect slip frequency from rotor slot harmonics of a three-phase squirrel-cage induction motor is proposed. The rotor slot harmonic voltage Is obtained by summing the three phase voltages, and after being sampled with a multiple of the stator frequency, it is changed into slip frequency waves, from which a voltage proportional to the slip frequency is obtained. Sophisticated sampling techniques allow elimination of the third harmonic voltage induced in the sum of the three-phase voltages and also allow reduction of time constant of the slip frequency detector. Expenmental results show that the slip frequency detector has a good linearity in the range of slip frequency of about -50 to +30 percent of the stator frequency. 相似文献
89.
Mizutani A Kikuta H Iwata K Toyota H 《Journal of the Optical Society of America. A, Optics, image science, and vision》2002,19(7):1346-1351
We describe a new structure of guided-mode resonant grating (GMRG) filters with low sideband reflectance. This GMRG filter consists of a high-index thin film on an antireflective structured surface called "moth-eye structure." Since the high-index film undulates along the surface structure, the film acts as a modulated optical waveguide. An incident light wave satisfying a resonant condition is reflected by the GMRG filter, and nonresonant light waves pass through the filter. This GMRG filter is valid for reducing reflection of nonresonant light waves in a wide spectral range. The resonant reflection of this new filter was investigated by numerical calculation based on an electromagnetic grating analysis. In the case of a triangular antireflective surface structure whose thickness is 2x greater than its period, the sideband reflectance for nonresonant light waves was lower than 0.5% for TM-polarized light in a wide range of wavelengths. 相似文献
90.
Hiroyasu Hotokezaka Noboru Aoyagi Yasuhiro Kawahara Noriko U. Yamaguchi Shinya Nagasaki Ken Sasaki Satoru Tanaka 《Microsystem Technologies》2005,11(8-10):974-979
Laser-induced breakdown spectroscopy (LIBS) has been applied for quantitative analysis of Al2O3, CaCO3 and MgO particles suspended in water. In the single elemental system, the plasma emission intensities of Al, Ca and Mg were linearly increased with concentration of elements in the range of 1.0×10?5–1.0×10?3 M, 1.0×10?4–2.0×10?3 M and 8.0×10?5 –4.0×10?3 M, respectively. We also investigated the concentration dependence of breakdown spectra for suspended mixtures of Al2O3, CaCO3 and MgO particles. The emission lines, such as Al I, Ca I, Ca II and Mg I, were appeared in the LIBS spectrum simultaneously, and each emission peak could be deconvoluted. The plasma emission intensities of Al, Ca and Mg in the multielemental system were also linearly increased with their concentrations in the range of 1.0×10?5–1.0×10?3 M, 1.0×10?4–2.0×10?3 M and 4.0×10?4–2.0×10?3 M, respectively. LIBS was found to be available for quantitative and qualitative measurement of the concentrations of Al2O3, CaCO3 and MgO particles suspended in water. The present results suggest that LIBS is a potentially useful tool for in-situ analysis on particles composition and concentrations for environmental monitoring by the wearable information equipments. 相似文献