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141.
142.
Low-pressure drying of apple tissue has been visualized in situ using an environmental scanning electron microscope (ESEM). Both freshly cut and pre-boiled sample tissues were tested for drying and followed by wetting processes and the differences between the two types of samples noted. Bubble formation was observed when drying the freshly cut sample and were found to form only around the intact cells (intracellular spaces or channels). Boiling produced a more uniform surface and no bubble formation could be observed. Air-drying of the two tissue samples was conducted as a complementary investigation so that the effect of boiling can be better ascertained.  相似文献   
143.
The wide range of advanced composite forming methods has motivated the development of new tooling materials capable of surviving processing extremes. Chemically Bonded Ceramic (CBC) tooling media have been formulated to supply molds with the strength, durability and thermal properties required in these applications. These inorganic materials retain relatively low cost and fabrication times. They incorporate a wide range of aggregates, fibers and inserts, selected to provide tools with desirable thermal and physical properties. CBC tools have been successfully utilized to form parts at temperatures ranging from ambient to 1800° F and at pressures as high as 10,000 psi. Chemically Bonded Ceramic tooting media provide an innovative alternative when more traditional tooling materials lack stability, durability, heat transfer capabilities or formability. This paper presents an overview of some applications in which Chemically Bonded Ceramic tooling have been used, and compares these materials to others which are commonly used in composite forming processes.  相似文献   
144.
Motivated by recent studies on tumor treatments using the drug delivery of nanoparticles, we provide a singular perturbation theory and perform Brownian dynamics simulations to quantify the extravasation rate of Brownian particles in a shear flow over a circular pore with a lumped mass transfer resistance. The analytic theory we present is an expansion in the limit of a vanishing Péclet number ( $P$ ), which is the ratio of convective fluxes to diffusive fluxes on the length scale of the pore. We state the concentration of particles near the pore and the extravasation rate (Sherwood number) to $O(P^{1/2})$ . This model improves upon previous studies because the results are valid for all values of the particle mass transfer coefficient across the pore, as modeled by the Damköhler number ( $\kappa $ ), which is the ratio of the reaction rate to the diffusive mass transfer rate at the boundary. Previous studies focused on the adsorption-dominated regime (i.e., $\kappa \rightarrow \infty $ ). Specifically, our work provides a theoretical basis and an interpolation-based approximate method for calculating the Sherwood number (a measure of the extravasation rate) for the case of finite resistance [ $\kappa \sim O(1)$ ] at small Péclet numbers, which are physiologically important in the extravasation of nanoparticles. We compare the predictions of our theory and an approximate method to Brownian dynamics simulations with reflection–reaction boundary conditions as modeled by $\kappa $ . They are found to agree well at small $P$ and for the $\kappa \ll 1$ and $\kappa \gg 1$ asymptotic limits representing the diffusion-dominated and adsorption-dominated regimes, respectively. Although this model neglects the finite size effects of the particles, it provides an important first step toward understanding the physics of extravasation in the tumor vasculature.  相似文献   
145.
In June 2021,the Ontario,Canada-based company Li-Cycle announced plans to,by the end of 2021,begin construction of North America's largest lithium-ion battery(L...  相似文献   
146.
    
An improvement in the thermoelectric power factor of Al doped ZnO has been achieved by means of co-doping with indium using a dual magnetron sputtering system. The concentration of indium in the film was varied from 0 to 10 atomic % by varying the RF power of the In target, with the ZnO:Al target fixed at 100 W. It has been found that the films with In concentrations at or below 5 at.% have no significant change in microstructure, and yet a marked improvement in thermopower. At higher doping levels, the Seebeck coefficient continues to increase, however poly-crystallinity is induced in the ZnO matrix which results in a considerable decrease in electrical conductivity. This factor ultimately has a negative impact on the materials power factor. Taking into account the films studied, (ZnO)Al.03In.02 exhibited the best thermoelectric properties with an electrical conductivity of 5.88 × 102 S/cm and a Seebeck coefficient of −220 μV/K at 975 K, resulting in a power factor is 22.1 × 10−4 Wm−1 K−2, which is three times greater than for the film with no In doping. Film microstructure, composition, and thermal stability were investigated using X-ray diffraction, scanning electron microscopy, and Auger electron spectroscopy.  相似文献   
147.
    
Discrete event simulation is a well-established tool for examining the effect of different operating room (OR) block schedules on various performance metrics within the OR suite and adjacent units. However, one unit that has rarely been studied is the sterilization processing department (SPD), which cleans and assembles reusable OR instruments. As part of a larger research study, we developed a series of OR block assignment models that sought to reduce the workload of the SPD and developed a tray optimization model to reduce the number of instruments on increasingly bloated instrument trays. While initial numerical experiments were promising, a comprehensive simulation model of the OR and SPD was needed to more thoroughly examine how potential changes to the block schedule and/or more efficient tray configurations could improve SPD processing times. In this article, we incorporate the SPD into an existing simulation model of an OR suite, which is the first of its kind, and examine the effect that different block schedules and tray configurations have on SPD processing times. Simulation results confirm earlier numerical computations. Furthermore, simulation results suggest that more efficient instrument tray configurations are a much better and more viable method for improving SPD processing time than reconfiguring block schedules.  相似文献   
148.
    
In this work, we investigated the potential for phosphorescent emitters to achieve the BT.2020 color standard in displays, where the CIE coordinates for red and green are (0.709, 0.292) and (0.170, 0.797), respectively. Optical simulations were performed for both green and red top emission organic light emitting devices (OLEDs). For the green emitter, it is possible to reach (0.170, 0.785) using a spectrum with a peak wavelength (λmax) at 526 nm and a full width at half maximum (FWHM) less than 30 nm. For the red emitter, in order to achieve (0.708, 0.292) while maintaining a high current efficiency (CE), it is important to decrease the FWHM instead of red-shifting the spectrum. Following the guidance of these simulation results, we designed and synthesized novel deep green (DGD) and deep red phosphorescent (DRD-II) emitters. The photoluminescent (PL) spectrum of DGD shows an FWHM of 30 nm and a λmax of 523 nm. A top-emission green OLED built using DGD reached a CE of 171 cd/A at an operating voltage of 3.3 V and a lifetime of 95% of initial brightness (LT95) > 1300 h at 10 mA/cm2 with a CIE (x, y) = (0.170, 0.777). This is, to our knowledge, the best device performance ever reported for a green phosphorescent OLED at this CIE y. The PL spectrum of DRD-II has a λmax of 630 nm with an FWHM of 30 nm. A top-emission red OLED built with DRD-II achieved a CE of 59 cd/A, an operating voltage of 3.2 V and an LT95 over 20,000 h at a drive current of 10 mA/cm2 with a CIE (x, y) = (0.708, 0.292). We also studied the angular dependence of the above devices and found they were comparable to devices with commercial emitters for the Digital Cinema Initiative P3 (DCI-P3) standard that had a wider FWHM. Combining these green and red emitters with a commercial blue OLED at (0.131, 0.046), we are able to cover 97% of the BT.2020 color gamut. The results using DGD and DRD-II suggest that they have great potential to satisfy BT.2020 in an organic phosphorescent system.  相似文献   
149.
    
The required steam for steam-assisted gravity drainage (SAGD) oil sands operations is generated using a once-through steam generator (OTSG) that is fed with relatively poor quality process water. Industries have reported possible solid particle erosion-related failure in the OTSG boiler tubes because of the transport of precipitated dense inorganic particles. However, the presence of other damage mechanisms, e.g. corrosion, flow accelerated corrosion (FAC), often masks the evidence of erosive wear. Also, industries set an upper limit operating velocity for the OTSG using the API RP 14E guideline, which provides no quantitative erosion rates to determine an operating envelope. This study presents a computational fluid dynamics (CFD) analysis of erosion damage in a SAGD OTSG boiler tube. The results revealed that API RP 14E may not be an effective decision-making tool for operating the OTSG system. For example, a 10% increase in velocity, even at conditions below the API RP 14E threshold, showed a decrease in the failure time of the boiler tubes by 40%–50%.  相似文献   
150.
    
Combinations of chemotherapeutic agents comprise a clinically feasible approach to combat cancers that possess resistance to treatment. Type II endometrial cancer is typically associated with poor outcomes and the emergence of chemoresistance. To overcome this challenge, a combination therapy is developed comprising a novel ciprofloxacin derivative-loaded PEGylated polymeric nanoparticles (CIP2b-NPs) and paclitaxel (PTX) against human type-II endometrial cancer (Hec50co with loss of function p53). Cytotoxicity studies reveal strong synergy between CIP2b and PTX against Hec50co, and this is associated with a significant reduction in the IC50 of PTX and increased G2/M arrest. Upon formulation of CIP2b into PEGylated polymeric nanoparticles, tumor accumulation of CIP2b is significantly improved compared to its soluble counterpart; thus, enhancing the overall antitumor activity of CIP2b when co-administered with PTX. In addition, the co-delivery of CIP2b-NPs with paclitaxel results in a significant reduction in tumor progression. Histological examination of vital organs and blood chemistry was normal, confirming the absence of any apparent off-target toxicity. Thus, in a mouse model of human endometrial cancer, the combination of CIP2b-NPs and PTX exhibits superior therapeutic activity in targeting human type-II endometrial cancer.  相似文献   
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