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951.
We conducted four studies to develop and validate measures of workplace safety-related behaviors relevant to young workers. The conceptual basis for this set of measures is a range of behavioral responses to deteriorating conditions (e.g., exit, voice, and loyalty, Hirschman, 1970; exit, voice, loyalty/patience, and neglect, Rusbult et al., 1982). In Study 1, items were generated by young workers (n = 39) who participated in focus groups. The representativeness of these items was judged in Study 2 by a separate sample of young workers (n = 79). In Study 3, we found support for five factors using exploratory factor analysis with a sample of young workers (n = 266). Confirmatory factor analysis was conducted in Study 4 using a separate sample (n = 282) and this supported the five-factor model. Self-report data on these participants and other-report (co-worker) data on a sub-sample (n = 26) of the same participants provided additional support for the validity of the scales. Overall, these studies support the validity and reliability of this set of safety-related behaviors: intentions to quit an unsafe job (exit), speaking out about safety concerns (voice), adapting to a dangerous job hoping that safety conditions improve (patience), deliberately letting safety conditions worsen (neglect), and following safety policies (compliance). This set is useful for evaluating safety interventions aimed at young workers and studying safety-related behavior in a vulnerable work population. 相似文献
952.
Sean P David David R Strong Marcus R Munafò Richard A Brown Elizabeth E Lloyd-Richardson Paul E Wileyto Eden A Evins Peter G Shields Caryn Lerman Raymond Niaura 《Nicotine & tobacco research》2007,9(12):1251-1257
We analyzed pooled data from two comparable randomized placebo-controlled clinical trials of bupropion pharmacotherapy for smoking cessation for which data on DRD2 Taq1A genotype were available. A total of 722 smokers across the two trials were randomized to 10 weeks of sustained-release bupropion hydrochloride or placebo. General estimating equation analysis demonstrated a significant gene x drug interaction (B = 0.87, SE = 0.34, p = .009). Smokers with the A2/A2 genotype using bupropion were more than three times as likely, relative to placebo, to be abstinent at end of treatment (35.2% vs. 15.1%; OR = 3.25, 95% CI 2.00-5.28) and at 6 months of follow-up (26.7% vs. 12.2%; OR = 2.81, 95% CI 1.66-4.77), which was attenuated by 12 months (16.3% vs. 10.7%; OR = 1.70, 95% CI 0.95-3.05). We found no significant benefit of bupropion relative to placebo on smoking cessation outcomes at any time point in participants with A1/A1 or A1/A2 genotypes. These data suggest that bupropion may be effective for smoking cessation only in a subgroup of smokers with the DRD2 Taq1 A2/A2 genotype. 相似文献
953.
Rezaul Kabir Tianshu Zhang Danyang Wang Richard Donelson Ruoming Tian Thiam Teck Tan Sean Li 《Journal of Materials Science》2014,49(21):7522-7528
Perovskite manganites CaMn1?y W y O3 (0 ≤ y ≤ 0.05) were synthesized using solid-state reaction technique. The influence of W doping on the structure, charge carrier transports and phonon scattering of CaMnO3 was investigated. Doping was found to increase the carrier concentration, leading to enhanced electrical conductivity and decreased Seebeck coefficient. In addition, it decreased the thermal conductivity of CaMnO3, which was believed to associate with decreased phonon mean path and doping-induced MnO6 octahedral distortion, as evidenced by the increased orthorhombicity. A twofold increase of figure of merit (ZT) of 0.15 at 973 K was observed in CaMn0.99W0.01O3, compared with the undoped CaMnO3. 相似文献
954.
Zhan Y Dewan M Harder M Krishnan A Zhou XS 《IEEE transactions on medical imaging》2011,30(12):2087-2100
Diagnostic magnetic resonance (MR) image quality is highly dependent on the position and orientation of the slice groups, due to the intrinsic high in-slice and low through-slice resolutions of MR imaging. Hence, the higher speed, accuracy, and reproducibility of automatic slice positioning, make it highly desirable over manual slice positioning. However, imaging artifacts, diseases, joint articulation, variations across ages and demographics as well as the extremely high performance requirements prevent state-of-the-art methods, such as volumetric registration, to be an off-the-shelf solution. In this paper, we address all these issues through an automatic slice positioning framework based on redundant and hierarchical learning. Our method has two hallmarks that are specifically designed to achieve high robustness and accuracy. 1) A redundant set of anatomy detectors are learned to provide local appearance cues. These detections are pruned and assembled according to a distributed anatomy model, which captures group-wise spatial configurations among anatomy primitives. This strategy brings about a high level of robustness and works even if a large portion of the target is distorted, missing, or occluded. 2) The detectors are learned and invoked in a hierarchical fashion, with each local detection scheduled and iterated according to its intrinsic invariance property. This iterative alignment process is shown to dramatically improve alignment accuracy. The proposed system is extensively validated on a large dataset including 744 clinical MR scans. Compared to state-of-the-art methods, our method exhibits superior performance in terms of robustness, accuracy, and reproducibility. The methodology is general and can be applied to other anatomies and other imaging modalities. 相似文献
955.
Aseel O. Rataan Sean M. Geary Yousef Zakharia Youcef M. Rustum Aliasger K. Salem 《International journal of molecular sciences》2022,23(4)
Selenium has been extensively evaluated clinically as a chemopreventive agent with variable results depending on the type and dose of selenium used. Selenium species are now being therapeutically evaluated as modulators of drug responses rather than as directly cytotoxic agents. In addition, recent data suggest an association between selenium base-line levels in blood and survival of patients with COVID-19. The major focus of this mini review was to summarize: the pathways of selenium metabolism; the results of selenium-based chemopreventive clinical trials; the potential for using selenium metabolites as therapeutic modulators of drug responses in cancer (clear-cell renal-cell carcinoma (ccRCC) in particular); and selenium usage alone or in combination with vaccines in the treatment of patients with COVID-19. Critical therapeutic targets and the potential role of different selenium species, doses, and schedules are discussed. 相似文献
956.
Joshua Branter Maria Estevez-Cebrero Mohammed Diksin Michaela Griffin Marcos Castellanos-Uribe Sean May Ruman Rahman Richard Grundy Surajit Basu Stuart Smith 《International journal of molecular sciences》2022,23(4)
The lack of treatment options for high-grade brain tumors has led to searches for alternative therapeutic modalities. Electrical field therapy is one such area. The Optune™ system is an FDA-approved novel device that delivers continuous alternating electric fields (tumor treating fields—TTFields) to the patient for the treatment of primary and recurrent Glioblastoma multiforme (GBM). Various mechanisms have been proposed to explain the effects of TTFields and other electrical therapies. Here, we present the first study of genome-wide expression of electrotherapy (delivered via TTFields or Deep Brain Stimulation (DBS)) on brain tumor cell lines. The effects of electric fields were assessed through gene expression arrays and combinational effects with chemotherapies. We observed that both DBS and TTFields significantly affected brain tumor cell line viability, with DBS promoting G0-phase accumulation and TTFields promoting G2-phase accumulation. Both treatments may be used to augment the efficacy of chemotherapy in vitro. Genome-wide expression assessment demonstrated significant overlap between the different electrical treatments, suggesting novel interactions with mitochondrial functioning and promoting endoplasmic reticulum stress. We demonstrate the in vitro efficacy of electric fields against adult and pediatric high-grade brain tumors and elucidate potential mechanisms of action for future study. 相似文献
957.
958.
Brad J. Gemmell Daniel R. Troolin John H. Costello Sean P. Colin Richard A. Satterlie 《Journal of the Royal Society Interface》2015,12(108)
Manoeuvrability is critical to the success of many species. Selective forces acting over millions of years have resulted in a range of capabilities currently unmatched by machines. Thus, understanding animal control of fluids for manoeuvring has both biological and engineering applications. Within inertial fluid regimes, propulsion involves the formation and interaction of vortices to generate thrust. We use both volumetric and planar imaging techniques to quantify how jellyfish (Aurelia aurita) modulate vortex rings during turning behaviour. Our results show that these animals distort individual vortex rings during turns to alter the force balance across the animal, primarily through kinematic modulation of the bell margin. We find that only a portion of the vortex ring separates from the body during turns, which may increase torque. Using a fluorescent actin staining method, we demonstrate the presence of radial muscle fibres lining the bell along the margin. The presence of radial muscles provides a mechanistic explanation for the ability of scyphomedusae to alter their bell kinematics to generate non-symmetric thrust for manoeuvring. These results illustrate the advantage of combining imaging methods and provide new insights into the modulation and control of vorticity for low-speed animal manoeuvring. 相似文献
959.
James P. Bridge Sean B. Holden Lawrence C. Paulson 《Journal of Automated Reasoning》2014,53(2):141-172
We applied two state-of-the-art machine learning techniques to the problem of selecting a good heuristic in a first-order theorem prover. Our aim was to demonstrate that sufficient information is available from simple feature measurements of a conjecture and axioms to determine a good choice of heuristic, and that the choice process can be automatically learned. Selecting from a set of 5 heuristics, the learned results are better than any single heuristic. The same results are also comparable to the prover’s own heuristic selection method, which has access to 82 heuristics including the 5 used by our method, and which required additional human expertise to guide its design. One version of our system is able to decline proof attempts. This achieves a significant reduction in total time required, while at the same time causing only a moderate reduction in the number of theorems proved. To our knowledge no earlier system has had this capability. 相似文献
960.
As the viral diseases such as Severe Acute Respiratory Syndrome (SARS) and Influenza A (H1N1) occur in many countries recently, the epidemic of those influenza viruses causes many human casualties. Moreover, the second infection from infected patients particularly within general hospitals frequently takes places due to improperly hospitalized and/or quarantined patients. Accordingly, it becomes a great concern to accommodate safer ventilation system in general hospital wards against such airborne transmitted viruses. It is also a recent trend that many urban general hospitals are designed and constructed as high-rises. If a virus is transmitted through uncontrolled air movement within a hospital and then infected other patients or healthy visitors, it might be impossible to control the spread of the disease. Thus research has been preceded scrutinizing stack effect on the indoor airborne virus transmission in large hospitals by conducting both the field measurement and numerical analysis according to the outdoor temperature and the releasing vertical points of the tracer gas assumed as a viral contaminant. In the field measurement of a high-rise hospital, the indoor airflow was affected by the stack effect of vertical chute of the building. The numerical simulation was verified by comparing its prediction results and the field measurement data. In result, very high possibility has witnessed that the airborne contaminant emitted from the infected patients in the lower floors could be transported to the higher floors through the airflow driven by the stack effect. 相似文献