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721.
Dennis Aschmann Dr. Cecilia Vallet Dr. Sunil K. Tripathi Dr. Yasser B. Ruiz-Blanco Max Brabender Prof. Dr. Carsten Schmuck Prof. Dr. Elsa Sanchez-Garcia Prof. Dr. Shirley K. Knauer Prof.Dr. Michael Giese 《Chembiochem : a European journal of chemical biology》2022,23(5):e202100618
Targeting specific protein binding sites to interfere with protein-protein interactions (PPIs) is crucial for the rational modulation of biologically relevant processes. Survivin, which is highly overexpressed in most cancer cells and considered to be a key player of carcinogenesis, features two functionally relevant binding sites. Here, we demonstrate selective disruption of the Survivin/Histone H3 or the Survivin/Crm1 interaction using a supramolecular approach. By rational design we identified two structurally related ligands ( LNES and LHIS ), capable of selectively inhibiting these PPIs, leading to a reduction in cancer cell proliferation. 相似文献
722.
Yasser Gowayed Faissal Abel‐Hady George T. Flowers Jeffrey J. Trudell 《Polymer Composites》2002,23(3):433-441
Design of composite flywheels made with reinforcement in the hoop and radial directions (Multiple Direction Composites MDC) involves a large multitude of parameters such as those related to the flywheel operation, flywheel geometry, material characteristics, material layup, and stress spatial distribution and values. The problem is further complicated because most design parameters are interactive and because one parameter cannot be optimized independent of the other parameters. Optimum structural design of MDC flywheels using nonlinear optimization via a sequential quadratic programming approach and parametric finite element analysis are used to address this problem. Numerical examples are solved to compare the efficacy of the two approaches. 相似文献
723.
Farzad Jani Saeed Houshmand Moayed Seyyed Reza Adhamdoust Abdolhannan Sepahi Seyyed Kamal Afzali 《加拿大化工杂志》2023,101(6):3409-3419
This paper presents applications of a new class of fibre optic acoustic emission (FOAE) sensor to monitor the operation of fluidized bed reactors used in polyethylene production. Specifically, the sensor was implemented to detect undesired, abnormal phenomena related to particle agglomeration, wall sheeting, fine overflow, and variations in the superficial gas velocity. The experiments were executed using a fluidized bed cold model setup for polyethylene powders with average particle sizes of 250, 1000, and 2000 μm. The results demonstrated that the presence of agglomerated particles in the fluidized bed reactor increases the kurtosis of the acoustic emission (AE) signal. Furthermore, the overflow of small particles can be detected by mounting the FOAE sensor below the gas distributor plate and monitoring an increase in the root mean square (RMS) of the AE signal. The AE signal RMS increased with the rising superficial gas velocity. Besides, forming a sheet layer on the reactor wall decreased the AE signal RMS. The proposed sensor's main benefits are its simple design, rapid response to abnormal conditions in the fluidized bed reactor, immunity against electromagnetic noise, high-temperature resistance, and safety in hazardous areas. 相似文献